Abstract
Henry reaction is a base-catalyzed reaction which can produce β-nitroalcohol or nitroethylene derivatives from the condensation of aryl aldehydes and nitromethane under different conditions. In the present article, we introduce hexamethylenetetramine as a basic organocatalyst for Henry reaction, which can produce β-nitroalcohol derivatives from the condensation of aryl aldehydes and nitromethane under different conditions. By application of this organic base, β-nitroalcohol compounds were produced as the only product in good to excellent yields. In addition, reusability of hexamethylenetetramine in this reaction makes our method green.
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We are grateful to the Research Council of Shiraz University for the partial support of this work.
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Fathi, S., Sardarian, A.R. Hexamethylenetetramine as an Efficient and Reusable Organocatalyst in Henry Reaction Under Mild and Aqueous Solution. Iran. J. Sci. Technol. Trans. Sci. 40, 103–107 (2016). https://doi.org/10.1007/s40995-016-0002-2
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DOI: https://doi.org/10.1007/s40995-016-0002-2