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Immature Teratoma with Gliomatosis Peritonei Arising in a Young Girl: Report of a Rare Case and Review of Literature

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Gliomatosis peritonei is a rare case occurring in association with teratoma of ovary. Only few cases have been reported in the literature so far. They are more commonly associated with immature teratomas as compared to mature teratoma of ovary. Though benign and graded as GRADE 0 by WHO fifth edition, they have a rare chance of malignant transformation as reported by some authors.

Case Report

A 31-year-old, unmarried and nulliparous lady presented with complaints of progressive abdominal distension and pain lower abdomen since 1 month. On radiology she was confirmed to have a large abdominopelvic mass with multiple omental and peritoneal deposits. A right-sided salpingo-ophrectomy with omentectomy was performed. A diagnosis of immature teratoma Grade 1 with gliomatosis peritonei was given on histopathology.


Though uncommon, a possibility of GP may be kept in mind for young patients having abdominopelvic masses with peritoneal deposits. A close follow-up is essential to monitor its recurrence, associated adhesions and rarely malignant transformation.

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  1. Singla G, Zaheer S, Singla S, Kolte S, Mandal AK. Gliomatosis peritonei in mature cystic teratoma. Indian J Pathol Microbiol. 2017;60:606–7.

    Article  PubMed  Google Scholar 

  2. Wang D, Jia CW, Feng R, Shi H, et al. Gliomatosis peritonei: a series of eight cases and review of the literature. J Ovar Res. 2016;9:45.

    Article  Google Scholar 

  3. Chou CY, Chang YL, Cheng WF, Chen CA. Mature cystic teratoma with gliomatosis peritonei. Taiwanese J Obstet Gynecol. 2005;44(2):183–6.

    Article  Google Scholar 

  4. Liang L, Zhang Y, Malpica A, et al. Gliomatosis peritonei: a clinicopathologic and immunohistochemical study of 21 cases. Mod Pathol. 2015;28:1613–20.

    Article  CAS  PubMed  Google Scholar 

  5. Female Genital Tumours WHO Classification of Tumours, Volume 4, 5th ed. WHO Classification of Tumours Editorial Board; 2020.

  6. Shefren G, Collin J, Soriero O. Gliomatosis peritonei with malignant transformation: a case report and review of literature. Am J Obstet Gynecol. 1991;164:1617–20.

    Article  CAS  PubMed  Google Scholar 

  7. Dadmanesh F, Miller DM, Swenerton KD, Clement PB. Gliomatosis peritonei with malignant transformation. Mod Pathol. 1997;10:597–601.

    CAS  PubMed  Google Scholar 

  8. Robboy SJ, Scully RE. Ovarian teratoma with glial implants on the peritoneum. An analysis of 12 cases. Hum Pathol. 1970;1:643–53.

    Article  CAS  PubMed  Google Scholar 

  9. Kim NR, Lim S, Jeong J, Cho HY. Peritoneal and nodal Gliomatosis with endometriosis, accompanied with ovarian immature teratoma: a case study and literature review. Korean J Pathol. 2013;47:587–91.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Ferguson AW, Katabuchi H, Ronnett BM, Cho KR. Glial implants in gliomatosis peritonei arise from normal tissue, not from the associated teratoma. Am J Pathol. 2001;159:51–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Yoon NR, Lee JW, Kim BG, et al. Gliomatosis peritonei is associated with frequent recurrence, but does not affect overall survival in patients with ovarian immature teratoma. Virchows Arch. 2012;461:299–304.

    Article  CAS  PubMed  Google Scholar 

  12. Harms D, Janig U, Gobel U. Gliomatosis peritonei in childhood and adolescence. Clinicopathological study of 13 cases including immunohistochemical findings. Pathol Res Pract. 1989;184:422–30.

    Article  CAS  PubMed  Google Scholar 

  13. Bentivegna E, Gonthier C, Uzan C, et al. Gliomatosis peritonei: a particular entity with specific outcomes within the growing teratoma syndrome. Int J Gynecol Cancer. 2015;25:244–9.

    Article  PubMed  Google Scholar 

  14. Nogales FF, Preda O, Dulcey I. Gliomatosis peritonei as a natural experiment in tissue differentiation. Int J Dev Biol. 2012;56(10–12):969–74.

    Article  CAS  Google Scholar 

  15. Norris HJ, Zirkin HJ, Benson WL. Immature (malignant) teratoma of the ovary. A clinical and pathologic study of 58 cases. Cancer. 1976;37:2359–72.

    Article  CAS  PubMed  Google Scholar 

  16. Nielsen SN, Scheithauer BW, Gaffey TA. Gliomatosis peritonei. Cancer. 1985;56:2499–503.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Ruchi Rathore.

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Ahuja, I., Rathore, R., Bhatla, N. et al. Immature Teratoma with Gliomatosis Peritonei Arising in a Young Girl: Report of a Rare Case and Review of Literature. Indian J Gynecol Oncolog 21, 73 (2023).

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