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Clinicopathological Features and Optimal Management of Sertoli–Leydig Cell Tumours of Ovary: A Retrospective Observational Study of Six Cases

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To evaluate clinicopathological features and optimal management of Sertoli–Leydig cell tumours (SLCTs) of ovary.


A retrospective observational analysis of patients with histopathological diagnosis of SLCT of ovary attending VPS Lakeshore Global Lifecare, Kochi, Kerala, between 2003 and 2018 was done.


During the study period, a total of six cases of SLCT of ovary were identified. Mean age was 26 years (8–47). The most common mode of presentation was abdominal pain in three (50%) cases. Clinically palpable mass was present in all the cases. The average maximum diameter of the ovarian mass was 14.9 cm (10.4–22 cm). Ultrasound scan showed unilateral solid cystic lesion with an increased vascularity in all the cases. Frozen section was done in two (33%) patients in view of patients’ desire for fertility-sparing surgery. Total abdominal hysterectomy with bilateral salpingo oophorectomy, omentectomy and bilateral pelvic lymph node dissection was done in four (66%) patients. The remaining two (33%) patients underwent unilateral salpingo oophorectomy in view of young age. One (17%) patient had well-differentiated histology, two (33%) patients had poorly differentiated histology, while three (50%) had intermediate-differentiated histology. Two (33%) patients received adjuvant chemotherapy. One patient had pelvic recurrence.


SLCTs are rare ovarian tumours with low malignant potential. Most of these cases are unilateral and present in stage I. Extra ovarian spread and lymph node involvement are rare in SLCTs. Young females can be treated with fertility-sparing surgery. However, owing to the rarity of the tumour and limited research data, there are no standard treatment guidelines.

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Correspondence to Remi Abdul Shukur.

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This is a retrospective study done in already available hospital data records.

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The need for ethical approval was waived due to retrospective nature of analysis. All data were anonymized before analysis. The study was performed in accordance with ethical standards laid down in 1964 declaration of Helsinki and its later amendments.

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This is a retrospective observational study. There was no direct involvement or intervention done to the patient during the study period from the author side.

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Abdul Shukur, R., Keshav, C., Puzhakkal, S. et al. Clinicopathological Features and Optimal Management of Sertoli–Leydig Cell Tumours of Ovary: A Retrospective Observational Study of Six Cases. Indian J Gynecol Oncolog 18, 7 (2020).

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