Abstract
Brain metastasis is a rare manifestation of any gynecological malignancy. Brain metastasis from ovarian cancers is rare but increasing in the post-chemotherapy era due to increased survival. We report a rare case of ovarian malignancy who had recurrence as an isolated brain metastasis soon after cytoreductive surgery followed by adjuvant chemotherapy. The management of such cases should be individualized based on site and extent of disease, which usually includes multimodality approach with surgery, radiation and chemotherapy.
References
Tosoni A, Ermani M, Brandes AA. The pathogenesis and treatment of brain metastases: a comprehensive review. Crit Rev Oncol Hematol. 2004;52(3):199–215.
Schouten LJ, Rutten J, Huveneers HAM, Twijnstra A. Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer. 2002;94(10):2698–705.
Piura E, Piura B. Brain metastases from ovarian carcinoma. ISRN Oncol. 2011;2011:13 (Article ID 527453).
Pectasides D, Pectasides M, Economopoulos T. Brain metastases from epithelial ovarian cancer: a review of the literature. Oncologist. 2006;11(3):252–60.
Bonnefoi H, A’Hern RP, Fisher C, et al. Natural history of stage IV epithelial ovarian cancer. J Clin Oncol. 1999;17(3):767–75.
Ogawa K, Yoshii Y, Aoki Y, et al. Treatment and prognosis of brain metastases from gynecological cancers. Neurol Med Chir. 2008;48(2):57–62.
Niu X, et al. Brain metastases in women with epithelial ovarian cancer: multimodal treatment including surgery or gamma-knife radiation is associated with prolonged survival. J Obstet Gynaecol Can. 2013;35(9):816–22.
Fidler IJ. The role of the organ microenvironment in brain metastasis. Semin Cancer Biol. 2011;21(2):107–12.
Longo R, et al. A late, solitary brain metastasis of epithelial ovarian carcinoma. BMC Cancer. 2014;14(1):543.
Pakneshan S, Safarpour D, Tavassoli F, et al. Brain metastasis from ovarian cancer: a systematic review. J Neurooncol. 2014;119:1.
Gigliotti MJ, Hasan S, Fuhrer R, Krivak T, Aziz K, Wegner RE. Linear accelerator-based radiosurgery and hypofractionated stereotactic radiotherapy for brain metastasis secondary to gynecologic malignancies: a single institution series examining outcomes of a rare entity. Gynecol Oncol Rep. 2018;25:19–23.
Kasper E, Ippen F, Wong E, Uhlmann E, Floyd S, Mahadevan A. Stereotactic radiosurgery for brain metastasis from gynecological malignancies. Oncol Lett. 2017;13(3):1525–8.
Rodriguez GC, Soper JT, Berchuck A, Oleson J, Dodge R, Montana G, Clarke-Pearson DL. Improved palliation of cerebral metastases in epithelial ovarian cancer using a combined modality approach including radiation therapy, chemotherapy, and surgery. J Clin Oncol. 1992;10:1553–60.
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Amrith, B.P., Koyyala, V.P.B., Dash, P.K. et al. A Rare Cause of Headache in Common Cancer: Ovarian Carcinoma with Brain Metastasis. Indian J Gynecol Oncolog 17, 11 (2019). https://doi.org/10.1007/s40944-018-0255-0
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DOI: https://doi.org/10.1007/s40944-018-0255-0