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Non-Invasive Imaging Modalities for Stem Cells Tracking in Osteoarthritis

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Abstract

Purpose

The administration of stem cells in regenerative medicine has emerged as a potential treatment option for many diseases. The privation of an impressive cure for joint pathologies such as knee osteoarthritis (OA) has increased concern in stem cell (SC)-based therapies.

Method

Searching for articles published in English from 1990 to 2022 using scientific keywords in Scopus and PubMed databases included in this comparative review study.

Result

Many questions remain about the survival and biology of SC after transplantation. Over time, non-invasive SC monitoring has been updated to assess the viability and biology of SC transplantation. The use of nanoparticles has become important in many aspects of SCs tracking. Given that different tracking strategies are being used for clinical trials, it is important to choose the best one.

Conclusion

In this review, various imaging methods, which were assimilated to monitor the viability and biology of SC after injection in osteoarthritis, were discussed.

Lay Summary

OA is a disabling disease which has different therapeutic including drugs or surgery. The aim of our study was to pool available data to obtain the most effective option for cell tracking in OA. Current progression in molecular biology and imaging has accredited winsome non-invasive SC monitoring in living subjects. Further effort should be placed on multimodal imaging techniques, which may minimize the potential venture of using any imaging technique.

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Data Availability

The data used in the current study are available from the corresponding authors on reasonable request.

Code Availability

There is no code in the manuscript.

Abbreviations

OA :

osteoarthritis

SC :

stem cells

RMT :

regenerative medicine therapies

SPECT :

single photon emission tomography

PET :

positron emission tomography

MRI :

magnetic resonance imaging

MSCs :

mesenchymal stem cells

BM-MSCs :

bone marrow derived mesenchymal stem cells

ADMSs :

adipose derived mesenchymal stem cells

ESC :

embryonic stem cells

iPSCs :

induced pluripotent stem cells

QD :

quantum dot

FL :

fluorescence

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Acknowledgements

No financial support was obtained from any institution in this study. The authors would like to thank Mr. Shahrad Khosravi radiology technologist in Shahvali hospital for his useful comments.

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Authors and Affiliations

  1. Department of Tissue Engineering and Applied Cell Science, Shiraz University of Applied Medical Science and Technologies, Shiraz, Iran

    Hengameh Dortaj & Ali Akbar Alizadeh

  2. Transplant Research Center, Shiraz University of Medical Science, Shiraz, Iran

    Negar Azarpira

  3. Marquette University School of Dentistry, Milwaukee, WI, 53233, USA

    Lobat Tayebi

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  1. Hengameh Dortaj
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  2. Ali Akbar Alizadeh
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  3. Negar Azarpira
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HD and NA conceived and designed the format of the manuscript. All authors contributed to the discussion. AA, NA, and LT drafted and edited the manuscript. All authors read and approved the final manuscript.

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Correspondence to Negar Azarpira.

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Dortaj, H., Alizadeh, A.A., Azarpira, N. et al. Non-Invasive Imaging Modalities for Stem Cells Tracking in Osteoarthritis. Regen. Eng. Transl. Med. 10, 9–18 (2024). https://doi.org/10.1007/s40883-023-00305-1

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