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Recent Patents Involving Stromal Vascular Fraction

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Abstract

Purpose

Aspirates from the liposuction procedures have been identified as a potential source of cells, termed the stromal vascular fraction (SVF) that could be utilized for regenerative engineering purposes owing to their multipotent capability. They stimulate regenerative effect through the secretion of biologically active molecules that act in a paracrine fashion to enhance angiogenic, anti-fibrotic, anti-apoptotic, and immuno-modulation responses at targeted tissue. As the prospects in SVF continue to drive interest among scientists, there have been corresponding innovations added, many of which have been patented or are currently in the process. This review aims at exploring the relevant additions to our previous knowledge of SVF.

Method

Patent on stromal vascular fraction, patent on adipose tissue, or adipose tissue products were searched on PubMed, PMC, Google Scholar, https://patents.justia.com/patent/, and http://www.patentsencyclopedia.com/app/ from 2005 to 2020. Withdrawn, abandoned, or inactive applications were excluded.

Result

There were many innovations in isolation methods, isolation kits, characterization molecules, purification, pharmacological mechanisms, and implant/graft/therapeutic applications of SVF. These were highlighted under subcategories and the scope of inventions including methods of cell isolation and processing; methods and devices for the application of SVF; and therapeutic application of SVF for diseased conditions. Each subcategory was further summarized by detailing its inventors, patent number, the field of invention, description, and major claims.

Conclusion

The recent patented innovations from basic and clinical studies indicate that SVF has the prospect of providing a better quality of life to patients. Though the FDA is yet to approve the clinical use of SVF, more studies are ongoing to standardize the processes involved and also provide more evidence to support the safety.

Lay Summary

The aspirates from liposuction contain a fraction that holds in native cells, termed the stromal vascular SVF. Due to the regenerative potentials of SVF, there has been an increased research interest, with corresponding discoveries. These include the methods of isolation, isolation kits, characterization and purification makers, mechanism of action, applications, and therapies. In this report, a summary of some of the active and recently applied patents on SVF was detailed. These native cells are made up of a mixture of populations, which has the potential for application in regenerative engineering. They can be obtained through mechanical or enzymatic means and produce their regeneration effect mainly by the secretion of bioactive molecules that can modulate immune responses and inflammations. In conclusion, these recent patented innovations indicated that SVF has the prospect of providing a better quality of life to patients; however, more studies are needed before approval from the FDA for clinical applications.

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Authors and Affiliations

  1. Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030-3711, USA

    Chinedu C. Ude, Godwin K. Dzidotor, Kamsiyochukwu Iloeje, Lakshmi S. Nair & Cato T. Laurencin

  2. Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health, Farmington, CT, USA

    Chinedu C. Ude, Godwin K. Dzidotor, Kamsiyochukwu Iloeje, Lakshmi S. Nair & Cato T. Laurencin

  3. Department of Orthopaedic Surgery, University of Connecticut Health, Farmington, CT, USA

    Chinedu C. Ude, Godwin K. Dzidotor, Kamsiyochukwu Iloeje, Lakshmi S. Nair & Cato T. Laurencin

  4. Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT, USA

    Godwin K. Dzidotor, Lakshmi S. Nair & Cato T. Laurencin

  5. Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA

    Godwin K. Dzidotor, Lakshmi S. Nair & Cato T. Laurencin

  6. Department of Materials Science and Engineering, University of Connecticut, Storrs, CT, USA

    Godwin K. Dzidotor, Lakshmi S. Nair & Cato T. Laurencin

  7. Department of Biology, Boston University, Massachusetts, USA

    Kamsiyochukwu Iloeje

  8. Institute of Materials Science, University of Connecticut, Storrs, CT, USA

    Cato T. Laurencin

  9. Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA

    Cato T. Laurencin

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  1. Chinedu C. Ude
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Ude, C.C., Dzidotor, G.K., Iloeje, K. et al. Recent Patents Involving Stromal Vascular Fraction. Regen. Eng. Transl. Med. 9, 295–314 (2023). https://doi.org/10.1007/s40883-022-00283-w

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