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Angiogenic Potential and Its Modifying Interventions in Dental Pulp Stem Cells: a Systematic Review

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Abstract

Background

Dental pulp stem cells (DPSCs) have been reported to have a pro-angiogenic effect indicative of the inherent property. Angiogenesis is a phenomenon crucial for wound healing, tissue regeneration, and vascularization of engineered scaffolds. Therefore, it is crucial to explore the angiogenic potential and the contributing factors in order to exploit this potential in stem cell research and tissue engineering.

Aim

To systematically review the literature on the angiogenic potential of DPSCs as well as to explore the effect of external environmental interventions on the angiogenic potential.

Methods

Three databases, PubMed, MEDLINE, and Cochrane, were systematically reviewed for literature with a suitable inclusion criterion. The data was screened for quantitative data for use in a meta-analysis.

Result

Overall, the studies indicated that DPSCs possess an inherent angiogenic potential that can be enhanced through external stimulation. The experimental methodology lacked consistency, and thus no quantitative data could be extracted for meta-analysis.

Conclusion

DPSCs are pro-angiogenic, which can be enhanced through external manipulation, making them a feasible option for use in tissue engineering and regenerative medicine. Consistency in experimental methodology is required in order to quantitatively analyze the angiogenic potential of DPSCs.

Lay Summary

The process of angiogenesis plays a central role in wound healing and tissue regeneration. Dental pulp stem cells or DPSCs are an excellent source of regenerative stem cells with immunomodulatory as well as immunomodulatory and renewal potential. Inherent properties of DPSCs can be utilized to enhance the process of wound healing and engineer tissue under laboratory conditions. The angiogenic potential of DPSCs can be enhanced through stimulation with conditioned media, growth factors, antibiotics, and dental fillings. Hypoxia and 3D cell culture would also benefit via the enhancement of the angiogenic property of DPSCs. Two broad categories of articles were included in this systematic review: directly assessing the angiogenic potential of DPSCs and studies assessing the effect of interventions on this potential.

Owing to their angiogenic potential, DPSCs can contribute greatly to the field of regenerative medicine in which cell growth is primarily hampered by the scarcity of oxygen supply due to the absence of blood vessels. Furthermore, DPSCs’ angiogenic potential invites new research avenues to assess the mechanism associated with angiogenesis and their use in therapeutics and regenerative medicine.

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Data Availability

All data presented in the study are available in the table provided. Any further inquiries may be directed to the corresponding author.

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Authors and Affiliations

  1. Logical Life Science Pvt. Ltd, Pune, Maharashtra, India

    Nilaja Badodekar, Smriti Mishra, Gaurang Telang, Shruti Chougule, Darpan Bennur & Nishant Vyas

  2. MGM School of Biotechnology, MGM Institute of Health Sciences, Navi Mumbai, Maharashtra, India

    Mansee Thakur

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Badodekar, N., Mishra, S., Telang, G. et al. Angiogenic Potential and Its Modifying Interventions in Dental Pulp Stem Cells: a Systematic Review. Regen. Eng. Transl. Med. 9, 52–82 (2023). https://doi.org/10.1007/s40883-022-00270-1

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