Carbon Nanofiber-Based Wearable Patches for Bio-Potential Monitoring



We fabricated a wearable patch including a novel patch-type flexible dry electrode based on carbon nanofibers (CNFs) and biocompatible PDMS (MED-6215) for long-term bio-potential monitoring.


The patch comprises dry electrode parts for recording bio signals and sticky parts for skin mounting. To evaluate electrical characteristics and electrocardiograph (ECG) recording, the CNF concentrations and dry electrode thickness were varied. The electromechanical properties of the dry electrode were tested under cyclic load conditions. Cytotoxicity tests and long-term wearing tests were conducted to prove biocompatibility.


The fabricated wearable patch is flexible, stretchable, easily skin mountable, and directly connectable with the measuring system. CNF concentrations is the most important variable compared with diameter, thickness for obtaining high-quality ECG signals. The electromechanical tests revealed excellent recovery performances in resistivity and durability. Cytotoxicity tests showed no effects on cells and long-term wearing tests showed no skin reactions.


The fabricated patch can be utilized for long-term bio-potential monitoring such as electromyography and electroencephalograms. The proposed dry electrode has flexibility, conductivity, and biocompatibility and is widely applicable to wearable sensors.


Recently, the wearable devices market has grown rapidly. Healthcare applications receive particular focus because many people want to be able to monitor their physical condition anywhere and at any time [1,2,3,4,5,6,7,8,9,10,11,12,13,14]. For successful monitoring with no skin irritation, long term wearable biocompatible electrodes are critical and electrocardiography is a key bio signal [15]. However, there are many remaining issues related to the battery, miniaturization, weight, and long-term biocompatibility.

The latest research solves these issues by recording bio-signals without the use of additive gels. Conventional electrodes are wet electrodes that include gels to improve adhesion onto the skin and resist external environmental factors; however, with time, dehydration of the gel causes decreasing signal quality, increasing signal noise, and skin irritation. Extensive research is attempting to solve these issues [2, 4, 6, 16,17,18,19,20,21,22,23].

In this study, we propose a carbon nanofiber (CNF)-based wearable patch that is directly connectable to conventional electrocardiograph (ECG) measuring devices. It is fabricated by assembling dry electrode and sticky patch components. CNFs are dispersed in a Polydimethylsiloxane (PDMS) matrix in order to develop a flexible nano-composite material as an electrode. PDMS, a well-known superior elastic, is flexible, has optically transparent properties, and has recently become a popular choice for biomedical applications because of its non- toxicity, high gas-permeability, and amenable fabric ability [24, 25]. Sylgard-184 is the most used PDMS in these applications but its biocompatibility must be evaluated because it was developed specifically for electronic and lighting uses. MED-6215 was developed for medical and implantable PDMS uses and is considered acceptable for human implantation for periods greater than 29 days according to biocompatibility tests [26, 27].

Conversely, carbon-based nanomaterials such as carbon nanotubes (CNTs) and CNFs show excellent mechanical, electrical, and thermal properties and are inert in the context of biomedical applications.

For these reasons, these materials have been widely used in a variety of applications. However, CNTs have questionable biocompatibility with the human body [28, 29] and CNFs are more easily uniformly dispersed in elastomer than CNTs because of aggregation conditions [30,31,32,33].

In this study, the dispersion protocol and concentrations were parametrized in order to achieve very good dispersion. To optimize electrical performance and the diffusion degree of uniformity, we developed a unique mixing and baking process. Secondly, sticky patch parts were made by patterning and detaching from a smooth surface substrate after spin-coating soft skin adhesive. In this process, the attachable and detachable strengths of the sticky patch are measured and optimized for use in a monitoring system. The electrical properties and biocompatibilities of the wearable patch were evaluated and ECG signals were measured by changing the CNF ratio and the thickness of the electrode.

Materials and Methods


CNFs (GNF-100, length 10–30 μm, diameter 50–200 nm, purity > 95%) were purchased from Carbon Nano-material Technology (Korea); Methyl group-terminated PDMS (MEP) which has properties [Serasense sf5, viscosity 5 mPa*s, relative density 0.95, specific gravity 0.915 (25 °C)] was purchased from KCC Corporation (Korea); and biocompatible PDMS [MED-6215, viscosity 3800 mPa*s, specific gravity 1.03 (25 °C)] and adhesive PDMS (MG 7-9850, viscosity 2900 mPa*s, adhesion 1.1 N/2.5 cm) were purchased from AvantorTM (USA) and Dow Corning (USA), respectively.

CNF Dispersion in PDMS

To fabricate the dry electrode parts, CNFs and MEP were dispersed in biocompatible PDMS (MED-6215). To optimize the electrical performance and diffusion degree of uniformity, we developed a unique mixing and baking process (Fig. 1). First, CNFs of different mixing ratios were poured in isopropyl alcohol (IPA) and mixed in a vortex shaker (VORTEX 1, IKA®) for 5 min. It is difficult for CNFs to be dispersed in biocompatible PDMS due to the high viscosity of PDMS (viscosity: 3800 mPa*s). To solve this problem, MEP (viscosity: 5 mPa*s) was poured in dispersed CNF/IPA and mixed in a vortex shaker for 5 min. Then, MED-6215 part A was added to the mixing solution and stirred on a hot plate at 100 °C until the IPA was completely evaporated from the mixing solution. Finally, MED-6215 part B was added in a mass ratio of 1:10 and stirred with sticks. Dry electrodes of diverse sizes and thicknesses, were prepared by pouring in a prepared mold and baking on a hot plate. For ease of demolding, the molds were immersed under methanol for 1 min; the methanol spread into small gaps, enabling separation [34]. The specific quantitative volume show below Table 1.

Fig. 1

Schematic diagram showing the process of CNF dispersal and dry electrode fabrication

Table 1 Specific quantitative volume

Fabrication of Wearable Patch

The wearable patch was assembled from two components: the dry electrode part for recording bio signals and the sticky patch part for mounting on the skin. The dry electrodes consisted of PDMS containing dispersed CNFs. The sticky patch parts were made by patterning and detaching from a smooth surface substrate after spin-coating and baking two types of PDMS. Non-adhesive PDMS (MED-6215) was spin coated on a glass wafer at 1000 rpm for 30 s and baked on a hotplate at 100 °C for 1 min. Then, adhesive PDMS (MG7-9850) was spin coated and baked under the same conditions. During this process, the attachable and detachable strengths of the sticky patch were measured and optimized for use in a wearable monitoring system. The two manufactured components were aligned and a hole was made in the center of the sticky component. For easy and repeated connection with a conventional signal processing system without any adapters, we inserted a conventional snap and polyester (PET) film into the hole. The construction of the wearable patches is shown in Fig. 2.

Fig. 2

Schematic of wearable patches

Characterization of Thermal Properties

To confirm thermal stability of the PDMS while heating process for fabricate dry electrode, we carried out the thermal gravimetric analysis (TGA). TGA of samples (weight: approximately 5–6 mg) was performed on a TGA Q50 (TA Instruments) under N2 gas atmosphere at a flow rate of 10 mL/min using platinum pans. Temperature profiles ranged from 25 to 400 °C with a heating rate of 10 °C/min.

Characterization of Electrical Properties

The sheet resistivity of the prepared samples was measured to evaluate the effect on electrical properties of CNF composition, thickness, and contact area. The CNF weight fraction and the contact area of the electrodes are thought to be critical factors determining the electrical properties. Fabricated CNF/PDMS electrodes are flexible, stretchable, and have no fixed shape, in contrast to commercial ECG electrodes (Ag/AgCl). Therefore, we measured the sheet resistivity according to different CNF ratios to investigate the effect of weight fraction.

Characterization of Electromechanical Properties

To evaluate the electromechanical properties of dry electrodes, the electrodes were tested under cyclic load conditions. Specimens with dimensions of 20 mm × 40 mm × 1 mm were prepared with stretching area dimensions of 20 mm × 20 mm × 1 mm. Prepared samples were fixed on a homemade motorized stretching machine and electrical resistivity was measured using a digital multimeter (Keysight 34410A) and a data acquisition program (Keysight BenchVue). The stretching length of the specimen was 1–6 mm (approximately 5–30%), and the electrical resistivity was measured in situ (sampling rate: 120 Hz). The hysteresis performance and strain profile of the dry electrodes were measured by incremental stretching (stretching speed: 1 mm/s). After stretching and releasing at each degree of strain (5, 10, 15, 20, 25, 30%), the apparatus was stopped for 15 s to relax the dry electrodes. The long-term durability of the dry electrodes were also tested by measuring the electrical resistivity sequentially over 10,000 cycles (stretching speed: 3 mm/s).

ECG Measurement

To acquire an ECG signal using the wearable patch, patches were placed on both wrists and the left ankle of human subjects. The ECG signal was amplified and acquired through a data acquisition system (BIOPAC systems MP36). Fabricated patches were evaluated through the measurement of ECG signals. These tests were performed for 60 s at a rate of 200 samples per second. To decrease the noise induced by the extension and movement cable of the ECG amplifier, cables from patches were fixed onto examinee’s wrists and ankles using compression bandages.

Biocompatibility Tests

L-929 (Mouse Fibroblasts) cells were purchased from ATCC (USA) and cultured in a minimum essential medium supplemented with 10% fetal bovine serum (FBS) and 1% penicillin–streptomycin (P/S) in a humid incubator at 37 °C and 5% CO2. In order to test the toxicity of the materials to cells, biocompatibility was verified by MTT test (ISO 10993-5:2009). To compare with conventional electrodes, we prepared both manufactured wearable patches and conventional electrodes. For these tests, confluent monolayer cells were adjusted to a density of 1 × 105 cells/mL, and 0.1 mL were added to each of 96 well plates. The wells were incubated for 24 h to obtain an 80% confluent monolayer of cells. The growth medium was discarded from the wells and replaced with 2 mL of the reagent control, negative control, positive control, and test sample. The MTT test measures the degree of cell growth at an absorbance of 570 nm. A decrease in number of living cells results in a decrease in the metabolic activity in the sample. This decrease directly correlates to the amount of blue-violet formazan formed, as monitored by the optical density at 570 nm. The lower the value of Viab.%, the higher the cytotoxic potential of the test sample. If viability is reduced to < 70% of the blank, it is judged to have cytotoxic potential.

The skin compatibility test was conducted on subjects wearing the wearable patch on their forearm for 7 days. During this time, observations were conducted of the side effects on the skin. To prevent inconvenience to the volunteer in their daily life, such as during bathing and exercise, a compression band was used to secure the wearable patch in case of necessity.

Results and Discussion

CNFs showed excellent dispersion properties in the PDMS prepolymer, and their mixing ratio was controlled as intended. Using the well-dispersed CNFs in PDMS, the fabrication of dry electrode parts was successfully performed by the processes described. Figure 3 illustrates a set of fabricated wearable patches; from left to right, the ratio of CNFs increased and the thickness was effectively controlled by the proposed replication method.

Fig. 3

Image of four fabricated types of wearable patch (left to right, 15, 20, 25, and 30 wt%)

We obtained plot of the TGA mass loss curves to confirm thermal stability of PDMS while fabricate dry electrode (Fig. 4). These showed the typical thermal degradation curve of PDMS and Td5% (the temperature at 5% weight loss) are shown around 210 °C (CNF/PDMS), 375 °C (PDMS). These results can explain PDMS withstand the process temperature (100 °C).

Fig. 4

TGA results for PDMS (a) and CNF/PDMS (b). (Red dot indicate Td5%)

The sheet resistivity of the four fabricated sets of CNF/PDMS composite (15, 20, 25, and 30 wt%) was analyzed, and their thickness and diameter effects were also evaluated (Fig. 5). It must be noted that if a value above 30 wt% is used then the surface of the electrode becomes too rough; and if the less than 15 wt% is used, then the electrical conductivity becomes too low.

Fig. 5

Sheet resistivity of dry electrodes. a Sheet resistivity as a function of the CNF weight fraction. (3 cm diameter, 2 mm thickness electrodes), b Sheet resistivity as a function of the thickness and diameter of the dry electrode (30 wt% electrodes)

To more clearly observe the difference, we fabricated circular samples. As expected, the sheet resistivity decreased with an increase in CNF weight fraction and thickness and diameter of the dry electrode. However, the thickness and diameter effects were almost negligible compared to the CNF weight fraction. For a small diameter dry electrode, the change ratio of resistivity is larger than for a large diameter dry electrode. Also, no ECG signal was recorded at a CNF ratio of < 25 wt% ratio in the PDMS electrode.

Figure 6 shows the relative change in resistivity (R/R0) against the applied strain for two types of electrodes (25 and 30 wt%). In this experiment, the CNF/PDMS specimens were well stretched, and the relative change in resistivity was not significant until 30% stretching. Moreover, the response to applied strain shows good linearity. The 20 wt% specimen data were not included in Fig. 5 because of not showing clear differences during stretching and too much noise.

Fig. 6

Influence of strain on the change ratio of resistivity

The elastic force and electrical resistivity of the dry electrode increased after decreasing the ratio of CNFs. Figure 7 presents the hysteresis performance of dry electrodes at different degrees of strain. The electrical resistivity of the dry electrodes was almost recovered after 30% stretching and releasing, demonstrating clear differences at each strain. However, short amounts of stretching and releasing at each strain led to sharp increases in the electrical resistance. This trend occurs because the CNFs rearrange in the PDMS elastomers under cyclic load conditions and the electrical resistance is restored with time.

Fig. 7

Hysteresis performance of dry electrodes at different strain levels. a 25 wt% CNF dry electrodes. b 30 wt% CNF dry electrodes. Inset shows the strain profile

Long-term durability tests were also performed at three degrees of strains (10, 20, and 30%, Fig. 8). All three samples showed excellent stability and recoverability over more than 10,000 cycles. The maximum relative change in resistance was 1.3, 2.7, and 3.1 at 10, 20, and 30% strain, respectively.

Fig. 8

Long-term durability test of dry electrodes over more than 10,000 cycles

Conventional Ag/AgCl electrodes and fabricated wearable patches were prepared (25 wt% CNF ratio, 2 mm thickness, 3 cm diameter) and ECG signals were measured. The typical ECG waves from each electrode are illustrated in Fig. 9. The quality of the ECG signal measured using PDMS electrodes with over 25 wt% CNFs remained similar despite changing thickness and diameter. Moreover, PQRST waves were clearly shown in this figure. The biocompatibility test was performed by MTT assay on the wearable patch (CNF/PDMS).

Fig. 9

Measured ECG signals from fabricated wearable patches and conventional electrodes

Conventional Ag/AgCl electrodes and a negative control were also analyzed to compare the relative levels of cell viability. As shown in Fig. 10, the viability of L-929 cells in the negative control and CNF/PDMS electrode after 48 h was 94% and 75.1%, respectively. Moreover, the cells on the CNF/PDMS electrode were alive and spread uniformly on the surface of the electrode. However, cell viability on the Ag/AgCl electrode was significantly lower than on the CNF/PDMS electrode and the cell condition was completely destroyed. We found that cell proliferation was clearly higher on the CNF/PDMS electrode after 48 h. These results reveal that CNFs and PDMS do not affect cells.

Fig. 10

Results of the biocompatibility test

The skin compatibility test was conducted over 7 days. The skin under the electrode was normal and no itching or erythema were observed after 7 days of wear (Fig. 11).

Fig. 11

Results of the long-term (7 days) skin compatibility test. a Image of wearing electrode on the skin. b Image of the skin after detaching electrode


In this study, we fabricated a simple carbon nanofiber-based wearable patch. The fabricated wearable patch was stretchable, skin-mountable, and biocompatible. The wearable patch was tested on three test subjects. The wearable patch showed potential for long-term measurement of ECG signals. The analysis of electrical characteristics showed that the ratio of CNFs is a key factor influencing electrical performance and ECG signal detection. In the ECG test, even though the amplitude was slightly lower than that of the Ag/AgCl electrode, PQRST waves were clearly visible and baselines were stable. In addition, we discovered that our electrode has no side effects such as itching or irritation even after 1 week of continuous wear. We expect that the proposed CNF/PDMS composite electrode has important applications for daily, universal, and mobile health care technology. The fabricated dry electrode may have other useful applications including strain, pressure, and temperature gauges in a variety of bio-signal monitoring equipment.


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This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MSIP) Grant No. [NRF-2016R1A5A1921651].

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Jung, H., Kwon, D., Lee, SA. et al. Carbon Nanofiber-Based Wearable Patches for Bio-Potential Monitoring. J. Med. Biol. Eng. 39, 892–900 (2019).

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  • Carbon nanofibers
  • Electrocardiograph
  • Wearable
  • Dry electrode