Peri-Therapeutic Quantitative Flow Analysis of Endovascular Revascularization for Ischemic Stroke Patients on Digital Subtraction Angiography

  • Shih-Neng Yang
  • Yu-Yi Lin
  • Tsung-Jung Ho
  • Shi-Yann Cheng
  • Yu-Rou Chiou
  • Chun-Han Liao
  • Geoffrey G. Zhang
  • Tzung-Chi HuangEmail author
Original Article


Digital subtraction angiography (DSA) and optical flow method (OFM) were integrated to quantitate cerebral blood flow in patients with ischemic stroke and the results were utilized to predict the outcome of treatment. A total of 34 patients with ischemic stroke who received endovascular therapy were included in this study. The post-treatment blood flow velocity was significantly higher (P < .001) than the pre-treatment velocity. Anterior–posterior blood flow gain was correlated with National Institute of Health Stroke Scale (NIHSS) score improvement and 90-day mRS. Patients with a higher blood flow gain (> median value of 33.36%) were more likely to have a higher MBD NIHSS improve score (> 4) than those with a lower blood flow gain (< median value). Quantitative digital subtraction angiography provides hemodynamic information for patients treated with endovascular revascularization, and offers a reliable follow-up evaluation for the ischemic stroke treatment.


Blood flow Digital subtraction angiography Ischemic stroke Optical flow method 


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Copyright information

© Taiwanese Society of Biomedical Engineering 2017

Authors and Affiliations

  • Shih-Neng Yang
    • 1
    • 2
  • Yu-Yi Lin
    • 3
    • 4
  • Tsung-Jung Ho
    • 5
    • 6
    • 7
  • Shi-Yann Cheng
    • 8
    • 9
  • Yu-Rou Chiou
    • 2
  • Chun-Han Liao
    • 10
  • Geoffrey G. Zhang
    • 11
  • Tzung-Chi Huang
    • 1
    • 12
    Email author
  1. 1.Department of Biomedical Imaging and Radiological ScienceChina Medical UniversityTaichungTaiwan
  2. 2.Department of Radiation OncologyChina Medical University HospitalTaichungTaiwan
  3. 3.Department of Nuclear MedicineChina Medical University Beigang HospitalYunlinTaiwan
  4. 4.Department of Nuclear Medicine, An Nan HospitalChina Medical UniversityTainanTaiwan
  5. 5.School of Chinese MedicineChina Medical UniversityTaichungTaiwan
  6. 6.Division of Chinese MedicineChina Medical University Beigang HospitalYunlinTaiwan
  7. 7.Division of Chinese Medicine, An Nan HospitalChina Medical UniversityTainanTaiwan
  8. 8.School of MedicineChina Medical UniversityTaichungTaiwan
  9. 9.Department of Obstetrics and GynecologyChin Medical University Beigang HospitalYunlinTaiwan
  10. 10.Department of RadiologyChina Medical University HospitalTaichungTaiwan
  11. 11.Department of Radiation OncologyMoffitt Cancer CenterTampaUSA
  12. 12.Department of Bioinformatics and Medical EngineeringAsia UniversityTaichungTaiwan

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