Journal of Medical and Biological Engineering

, Volume 36, Issue 4, pp 495–505 | Cite as

Factorial Analysis of Variables Influencing Mechanical Characteristics in Le Fort I Osteotomy Using FEA and Statistics-Based Taguchi Method

Original Article


This study investigated the Le Fort I osteotomy biomedical interactions for multi-factorial parameters (bone healing situation, cortical bone thickness, mini-plate fixation type, and screw length) under oblique load conditions using a nonlinear finite element (FE) approach. Nonlinear FE analysis was used to simulate the screw/plate and plate/bone and the bone healing adaptations with osseous nonunion in Le Fort I osteotomy models. The Taguchi method was used to identify the importance of each parameter and determine an optimal biomechanical response. With respect to relative micro-movement between the two bone segments and the magnitude of the stress values in the mini-plates, the bone healing situation had the dominant effect. The main effect plot showed that osseous nonunion increased the micro-movements and mini-plate stress values. Cortical bone thickness, mini-plate fixation type and screw length did not significantly affect the micro-movement and stress values. The combined use of FE analysis and the Taguchi method facilitated effective Le Fort I osteotomy mechanical characteristics evaluation.


Le Fort I osteotomy Finite element Taguchi Bone healing 



This study in part by MOST Project 103-2221-E-010 -012 -MY3 of the Ministry of Science and Technology, Taiwan and Project CRRPG5C0292 of Chang Gung Memorial Hospital, Tao-yuan, Taiwan.

Compliance with Ethical Standards

Conflicts of interest

The authors have no conflicts of interests to declare.


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Copyright information

© Taiwanese Society of Biomedical Engineering 2016

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringNational Yang-Ming UniversityTaipeiTaiwan
  2. 2.Department of Plastic and Reconstructive SurgeryChang Gung Memorial HospitalTaoyuanTaiwan

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