Skip to main content
SpringerLink
Log in

Two-dimensional transistor sensors for biomedical detection

用于生物医学检测的二维晶体管传感器

  • Perspective
  • Published:
Science China Materials Aims and scope Submit manuscript

摘要

精确、 快速的生物医学检测对于更好的健康监测和及时的治疗具有十分重要的作用. 因二维(2D)半导体材料具有高灵敏度、 高比表面积以及一步电学信号读取等优势, 通过将特定探针构筑在其表面, 2D晶体管生物传感器具有巨大的优势. 尽管研究者们构建出了各类2D晶体管传感器, 但它们在单器件级别的性能和功能受到传感界面和晶体管结构设计的限制, 且其商业化仍具有挑战. 这里, 我们概述了晶体管传感器面临的主要挑战, 并探讨了应对这些挑战的晶体管传感器设计与开发思路. 最后, 强调了该类2D晶体管传感系统走向商业化需做出的改进. 与其他电学传感器相关技术的发展历程类似, 文中所阐述的观点也对生物电子学其他领域的发展具有一定的启示作用.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Liu D, Chen X, Hu Y, et al. Raman enhancement on ultra-clean graphene quantum dots produced by quasi-equilibrium plasma-enhanced chemical vapor deposition. Nat Commun, 2018, 9: 193

    Article  Google Scholar 

  2. Sreekumar A, Poisson LM, Rajendiran TM, et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature, 2009, 457: 910–914

    Article  CAS  Google Scholar 

  3. Chambers JM, Hill PA, Aaron JA, et al. Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase. J Am Chem Soc, 2009, 131: 563–569

    Article  CAS  Google Scholar 

  4. Wongkaew N, Simsek M, Griesche C, et al. Functional nanomaterials and nanostructures enhancing electrochemical biosensors and lab-on-a-chip performances: Recent progress, applications, and future perspective. Chem Rev, 2018, 119: 120–194

    Article  Google Scholar 

  5. Eswaran M, Chokkiah B, Pandit S, et al. A road map toward field-effect transistor biosensor technology for early stage cancer detection. Small Methods, 2022, 6: 2200809

    Article  CAS  Google Scholar 

  6. Wadhera T, Kakkar D, Wadhwa G, et al. Recent advances and progress in development of the field effect transistor biosensor: A review. J Elec Materi, 2019, 48: 7635–7646

    Article  CAS  Google Scholar 

  7. Ohno Y, Maehashi K, Matsumoto K. Label-free biosensors based on aptamer-modified graphene field-effect transistors. J Am Chem Soc, 2010, 132: 18012–18013

    Article  CAS  Google Scholar 

  8. Fan Q, Wang L, Xu D, et al. Solution-gated transistors of two-dimensional materials for chemical and biological sensors: Status and challenges. Nanoscale, 2020, 12: 11364–11394

    Article  CAS  Google Scholar 

  9. Wang X, Hao Z, Olsen TR, et al. Measurements of aptamer–protein binding kinetics using graphene field-effect transistors. Nanoscale, 2019, 11: 12573–12581

    Article  CAS  Google Scholar 

  10. Kuila T, Bose S, Khanra P, et al. Recent advances in graphene-based biosensors. Biosens Bioelectron, 2011, 26: 4637–4648

    Article  CAS  Google Scholar 

  11. Chen F, Tang Q, Ma T, et al. Structures, properties, and challenges of emerging 2D materials in bioelectronics and biosensors. InfoMat, 2022, 4: e12299

    Article  CAS  Google Scholar 

  12. Dai C, Liu Y, Wei D. Two-dimensional field-effect transistor sensors: The road toward commercialization. Chem Rev, 2022, 122: 10319–10392

    Article  CAS  Google Scholar 

  13. Wang Z, Yi K, Lin Q, et al. Free radical sensors based on inner-cutting graphene field-effect transistors. Nat Commun, 2019, 10: 1544

    Article  Google Scholar 

  14. Sarkar D, Liu W, Xie X, et al. MoS2 field-effect transistor for next-generation label-free biosensors. ACS Nano, 2014, 8: 3992–4003

    Article  CAS  Google Scholar 

  15. Wang L, Wang X, Wu Y, et al. Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples. Nat Biomed Eng, 2022, 6: 276–285

    Article  CAS  Google Scholar 

  16. Hajian R, Balderston S, Tran T, et al. Detection of unamplified target genes via CRISPR-Cas9 immobilized on a graphene field-effect transistor. Nat Biomed Eng, 2019, 3: 427–437

    Article  CAS  Google Scholar 

  17. Hwang MT, Heiranian M, Kim Y, et al. Ultrasensitive detection of nucleic acids using deformed graphene channel field effect biosensors. Nat Commun, 2020, 11: 1543

    Article  CAS  Google Scholar 

  18. Li Y, Zhu Y, Wang C, et al. Selective detection of water pollutants using a differential aptamer-based graphene biosensor. Biosens Bioelectron, 2019, 126: 59–67

    Article  CAS  Google Scholar 

  19. Zhu Y, Hao Y, Adogla EA, et al. A graphene-based affinity nanosensor for detection of low-charge and low-molecular-weight molecules. Nanoscale, 2016, 8: 5815–5819

    Article  CAS  Google Scholar 

  20. Palazzo G, De Tullio D, Magliulo M, et al. Detection beyond Debye’s length with an electrolyte-gated organic field-effect transistor. Adv Mater, 2015, 27: 911–916

    Article  CAS  Google Scholar 

  21. Stern E, Wagner R, Sigworth FJ, et al. Importance of the Debye screening length on nanowire field effect transistor sensors. Nano Lett, 2007, 7: 3405–3409

    Article  CAS  Google Scholar 

  22. Schrittwieser JH, Velikogne S, Hall M, et al. Artificial biocatalytic linear cascades for preparation of organic molecules. Chem Rev, 2018, 118: 270–348

    Article  CAS  Google Scholar 

  23. Shaw A, Hoffecker IT, Smyrlaki I, et al. Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies. Nat Nanotech, 2019, 14: 184–190

    Article  CAS  Google Scholar 

  24. Hao Z, Luo Y, Huang C, et al. An intelligent graphene-based biosensing device for cytokine storm syndrome biomarkers detection in human biofluids. Small, 2021, 17: 2101508

    Article  CAS  Google Scholar 

  25. Hao Z, Pan Y, Shao W, et al. Graphene-based fully integrated portable nanosensing system for on-line detection of cytokine biomarkers in saliva. Biosens Bioelectron, 2019, 134: 16–23

    Article  CAS  Google Scholar 

  26. Dey S, Fan C, Gothelf KV, et al. DNA origami. Nat Rev Methods Primers, 2021, 1: 13

    Article  Google Scholar 

  27. Zhang H, Wang Z, Wang Z, et al. Recent progress of fiber-based transistors: Materials, structures and applications. Front Optoelectron, 2022, 15: 2

    Article  Google Scholar 

  28. Han M, Chen L, Aras K, et al. Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery. Nat Biomed Eng, 2020, 4: 997–1009

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Key R&D Program of China (2021YFE0201400), the National Natural Science Foundation of China (61890940), Chongqing Bayu Scholar Program (DP2020036), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB30000000), the Program of Shanghai Academic Research Leaders (23XD1420200), China Postdoctoral Science Foundation (2019M661353), the National Postdoctoral Program for Innovative Talents (BX20190072), and the State Key Laboratory of Molecular Engineering of Polymers and Fudan University.

Author information

Authors and Affiliations

  1. State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China

    Xuejun Wang  (王学军) & Dacheng Wei  (魏大程)

  2. Department of Macromolecular Science, Fudan University, Shanghai, 200433, China

    Xuejun Wang  (王学军) & Dacheng Wei  (魏大程)

  3. Laboratory of Molecular Materials and Devices, Fudan University, Shanghai, 200433, China

    Xuejun Wang  (王学军) & Dacheng Wei  (魏大程)

Authors
  1. Xuejun Wang  (王学军)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dacheng Wei  (魏大程)
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Author contributions Wei D conceived the study and Wang X carried out the investigation and draft writing. Wei D supervised the entire study and offered the main funding.

Corresponding author

Correspondence to Dacheng Wei  (魏大程).

Ethics declarations

Conflict of interest The authors declare that they have no conflict of interest.

Additional information

Xuejun Wang received his PhD degree in mechanical engineering from the East China University of Science and Technology in 2019. He worked as a visiting PhD student at Columbia University from 2014 to 2017. Since 2019, he has been a postdoc at Fudan University. His current research interests are focused on transistor biosensors and DNA nanotechnology.

Dacheng Wei received his PhD degree from the Institute of Chemistry, Chinese Academy of Sciences in 2009. He worked at the National University of Singapore as a Lee Kuan Yew Research Fellow from 2009 to 2014, during which he worked as a postdoc at Stanford University from 2010 to 2011. He has been a professor at Fudan University since 2014. His research interests include semiconducting materials, transistor devices and their applications in biomedical detection and photodetection.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, X., Wei, D. Two-dimensional transistor sensors for biomedical detection. Sci. China Mater. 66, 3795–3798 (2023). https://doi.org/10.1007/s40843-023-2589-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40843-023-2589-9

Search

Navigation