Abstract
The porous structure formed by the self-assembly of peptides is a new generation of porous materials with potential applications in the fields of catalysis, sensing, separation, and drug delivery. The pores of the material are filled with amino acid side chains, so the pore size and properties of the peptide-based porous material can be adjusted by rational design or modification of the peptide sequences. The introduction of functional moieties and metal ions has expanded the range of peptide-based porous materials. This review covers the design, synthesis, self-assembly, and properties of peptide-based porous materials, and summarizes their applications in different fields in recent years.
摘要
多肽自组装形成的多孔结构是新一代多孔材料, 在催化、传感、分离和药物递送等领域具有很好的应用前景. 肽基多孔材料的孔内充满氨基酸侧链, 因此可以通过合理设计或修改肽序列来调节其孔径大小和性能. 功能基团和金属离子的引入进一步扩展了多肽基多孔材料的结构与性能. 在这篇综述中, 我们讨论了肽基多孔材料的设计、合成、组装及其性能, 并综述了近年来其在不同领域的应用.
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Acknowledgements
This work was supported by the National Natural Science Foundation of China (22278306, 22278314, 21621004 and 22078239) and the State Key Laboratory of Chemical Engineering (SKL-ChE-21T03).
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Wang Y conceived the idea. Wang Y, Min J, Wei H, Liu J, and Liang Y wrote the manuscript. Wang Y, Wang Y (Tianjin University of Traditional Chinese Medicine), and Qi W revised the manuscript. Zhang G, Zhang W, and Su R provided meaningful suggestions.
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The authors declare that they have no conflict of interest.
Yuefei Wang obtained his PhD degree from Tianjin University, China in 2015. He is now an associated professor at the School of Chemical Engineering and Technology, Tianjin University. He joined the State Key Laboratory of Chemical Engineering in 2017 and worked as a visiting scholar in the lab of Prof. Nicholas A. Kotov at the University of Michigan, Ann Arbor, USA, in 2018. His research interests mainly focus on chiral peptide nanomaterials, drug delivery and biocatalysis.
Yuefei Wang obtained his PhD degree from Tianjin University of Traditional Chinese Medicine (Tianjin, China) in 2011. He is a professor in the Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine. He joined the State Key Laboratory of Component-based Chinese Medicine in 2020 and Haihe Laboratory of Modern Chinese Medicine in 2021. He is committed to exploring the active substances and mechanism of traditional Chinese medicine, and quality control of Chinese Materia Medica.
Wei Qi received her PhD degree in chemical engineering from Tianjin University in 2002 and was a visiting scholar at the University of Illinois at Urbana-Champaign, USA from 2012–2013. She has been a professor of chemical and biochemical engineering at Tianjin University since 2009 and is now the director of the Graduate Education Office, Graduate School of Tianjin University. Her research interest involves the development of biochemicals, biofuels and biomaterials via biocatalysis and industrial catalysis.
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Wang, Y., Min, J., Wei, H. et al. Peptide-based porous materials and their applications. Sci. China Mater. 66, 470–484 (2023). https://doi.org/10.1007/s40843-022-2285-5
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DOI: https://doi.org/10.1007/s40843-022-2285-5