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A donor-acceptor covalent organic framework as the promising construct for photothermal therapy

基于供体-受体原理构建的共价有机框架材料用于癌症的光热治疗

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Abstract

A donor-acceptor covalent organic framework (COF), TB-COF, constructed from an electron-rich building unit (donor) and an electron-deficient building unit (acceptor), was developed as a promising photothermal agent for photothermal therapy (PTT). Upon laser irradiation, significant photoinduced electron transfer (PET) occurs between the donor and acceptor in TB-COF, converting the absorbed optical energy to thermal energy and resulting in the ablation of tumor. TB-COF possessed satisfying photothermal conversion efficiency, reaching 43.65%, similar to materials commonly used for PTT. Moreover, hyaluronic acid (HA) was coated on TB-COF to improve its biocompatibility and achieve tumor targeting. Furthermore, in vitro and in vivo experiments confirmed satisfying photothermal anticancer efficacy of TB-COF-HA.

摘要

我们设计合成了一例共价有机框架材料(TB-COF), 并将其开发应用为癌症的光热治疗试剂. TB-COF是基于供体-受体原理, 由富电子构建单元(供体)和缺电子构建单元(受体)构建而成. 当受到激光照射时, TB-COF中供体和受体之间会发生显著的光诱导电子转移, 将吸收的光能转化为热能并用于肿瘤消融. TB-COF具有优异的光热转换效率, 其值可达43.65%, 与常用的光热试剂相当. 此外, 我们还将透明质酸(HA)包覆在TB-COF上, 以提高其生物相容性并实现肿瘤靶向功能. 体外和体内实验均证实了TB-COF-HA高效的光热抗癌功能.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (22104074, 22274089, and 21965011), the Natural Science Foundation of Shandong Province (ZR2022YQ10 and ZR2020QB106), the Local Science and Technology Development Fund Guided by the Central Government (YDZX20203700002568), the Natural Science Foundation of Hainan Province (220RC458), and the Major Science and Technology Plan of Hainan Province (ZDKJ202016).

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, China

    Xiuyan Wan  (万秀艳), Jie Zhang  (张洁), Huiwen Zhang  (张惠文), Wei Pan  (潘伟), Na Li  (李娜) & Bo Tang  (唐波)

  2. Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan University, Haikou, 570228, China

    Kaiming Zuo  (左凯明), Hui Hu  (胡慧) & Yanan Gao  (高艳安)

Authors
  1. Xiuyan Wan  (万秀艳)
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  2. Jie Zhang  (张洁)
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  3. Kaiming Zuo  (左凯明)
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  5. Hui Hu  (胡慧)
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  6. Wei Pan  (潘伟)
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  7. Yanan Gao  (高艳安)
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  8. Na Li  (李娜)
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  9. Bo Tang  (唐波)
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Contributions

Author contributions Tang B, Li N, and Gao Y designed the study and supervised the project; Wan X, Zhang J, and Zuo K conceived the experimental scheme and performed the experiments; Zhang J and Zhang H carried out the in vitro and in vivo experiments; Wan X, Zhang J, Zuo K, and Hu H performed data analysis; Wan X wrote the paper with support from Pan W. All authors contributed to the general discussion.

Corresponding authors

Correspondence to Yanan Gao  (高艳安), Na Li  (李娜) or Bo Tang  (唐波).

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Conflict of interest The authors declare that they have no conflict of interest.

Additional information

Supplementary information Experimental details and supporting data are available in the online version of the paper.

Xiuyan Wan received her PhD degree in inorganic chemistry from Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences. She is now an associate professor and master supervisor at Shandong Normal University. Her research mainly focuses on MOF- and COF-based materials and their applications in cancer therapy.

Bo Tang obtained his PhD degree in analytical chemistry in 1994 from Nankai University. Then he joined the College of Chemistry, Chemical Engineering and Materials Science as a full professor at Shandong Normal University. His current research interests include the development of molecular and nanoprobes for analytical and biomedical applications, solar energy chemical transformation and storage, and clean synthesis of chemicals.

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Wan, X., Zhang, J., Zuo, K. et al. A donor-acceptor covalent organic framework as the promising construct for photothermal therapy. Sci. China Mater. 66, 1227–1236 (2023). https://doi.org/10.1007/s40843-022-2232-4

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