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Exfoliated FePS3 nanosheets for T1-weighted magnetic resonance imaging-guided near-infrared photothermal therapy in vivo

剥离的FePS3纳米片及其活体内T1加权磁共振成 像介导的近红外光热治疗研究

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Abstract

Developing bifunctional nanoplatforms integrating advanced biological imaging with high-performance therapeutic functions is interesting for nanoscience and biomedicine. Herein, thin-layered FePS3 nanosheets modified with amine polyethylene glycol (FePS3-PEG) are synthesized by ultrasonicated exfoliation of bulk FePS3 single crystals under Ar atmosphere and in situ chemical functionalization with amine PEG. The prepared FePS3-PEG nanosheets give a photothermal conversion efficiency of 22.1% under 808-nm laser and evident T1 relaxation (r1 = 2.69 (mmol L−1)−1 S−1) in external magnetic fields. Biologically experimental results in vitro and in vivo demonstrate that FePS3-PEG nanosheets have good biocompatibility and exhibit excellent photothermal therapy (PTT) effect under clear T1 weighted magnetic resonance imaging (MRI). The characteristics of FePS3-PEG nanosheets enable them to be a promising nanomedicine for T1-weighted MRI-guided near-infrared PTT of cancers.

摘要

开发具有先进生物成像和高性能诊疗功能的纳米平台对于 纳米科学与生物医药研究有重要意义. 本文中, 我们通过在氩气中 超声剥离FePS3单晶并同步化学修饰氨基聚乙二醇制备了氨基聚乙 二醇功能化的FePS3纳米片(FePS3-PEG), FePS3-PEG纳米片在 808 nm激光下的光热转化效率可达22.1%, 并在外界磁场中显示了 明显的T1弛豫效应(r1 = 2.69 (mmol L−1)−1 S−1). 体内外的生物实验 结果表明, FePS3-PEG纳米片具有良好的生物相容性, 在清晰的T1 加权磁成像介导下展现出优异的光热治疗效果. FePS3-PEG纳米片 的特性使其成为有前景的癌症T1加权磁成像介导的近红外光热治 疗纳米药物.

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Acknowledgements

This work was supported by the National Key Research and Development Program of China (2017YFA0205302), the Key Grant for Special Professors in Jiangsu Province (RK030STP18001), the Key Research and Development Program of Jiangsu (BE2018732), the Natural Science Key Fund for Colleges and Universities in Jiangsu Province (17KJA430011), the National Postdoctoral Program for Innovative Talents (BX20190156), the Scientific Research Foundation of Nanjing University of Posts and Telecommunications (NY218150), the Training Program of the Major Research Plan of the National Natural Science Foundation of China from Nanjing University of Posts and Telecommunications (NY218158), “1311 Talents Program” of Nanjing University of Posts and Telecommunications, “100 Top Talents Program” of Sun Yat-sen University (29000-18841216), “Young-Teacher Training Program” of Sun Yat-sen University (29000-31610036), Joint Funds for the Innovation of Science and Technology in Fujian Province (2017Y9111), and the Natural Science Foundation of Fujian Province (2020J01613).

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Authors and Affiliations

  1. State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), College of Electronic and Optical Engineering & College of Microelectronic, Nanjing University of Posts and Telecommunications, Nanjing, 210023, China

    Ying Zhang  (张颖), Hongfang Du  (都洪芳), Panpan He  (何盼盼), Chuang Shen  (沈闯), Qi Li  (李琦), Yefan Duan  (段叶凡), Zhouwei Shao  (邵周伟), Fei Mu  (牟菲), Zhimin Luo  (罗志敏) & Lianhui Wang  (汪联辉)

  2. School of Materials Science and Engineering, State Key Laboratory of Optoelectronic Materials and Technologies, School of Materials, Sun Yat-sen University, Guangzhou, 510275, China

    Peiyang Li  (李霈旸), Pingqi Gao  (高平齐) & Peng Yu  (于鹏)

  3. Department of Human Anatomy, School of Basic Medical Sciences, Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province, Fujian Medical University, Fuzhou, 350122, China

    Feng Huang  (黄峰)

Authors
  1. Ying Zhang  (张颖)
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  2. Hongfang Du  (都洪芳)
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  3. Panpan He  (何盼盼)
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  4. Chuang Shen  (沈闯)
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  5. Qi Li  (李琦)
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  6. Yefan Duan  (段叶凡)
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  7. Zhouwei Shao  (邵周伟)
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  8. Fei Mu  (牟菲)
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  9. Feng Huang  (黄峰)
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  12. Peng Yu  (于鹏)
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  13. Zhimin Luo  (罗志敏)
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  14. Lianhui Wang  (汪联辉)
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Contributions

Zhang Y designed the experiments and wrote the draft of manuscript. Du H, He P, Shen C and Li Q prepared the FePS3-PEG nanosheets and characterized them. Duan Y, Shao Z, Mu F and Huang F designed and carried out the biological experiments. Li P, Gao P and Yu P provided suggestions and comments on the manuscript. Luo Z and Wang L proposed the project and revised the manuscript.

Corresponding authors

Correspondence to Feng Huang  (黄峰), Peng Yu  (于鹏), Zhimin Luo  (罗志敏) or Lianhui Wang  (汪联辉).

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Conflict of interest

The authors declare that they have no conflict of interest.

Ying Zhang obtained her PhD degree in bioelectronics from Nanjing University of Posts and Telecommunications (NJUPT) in 2016. She is now an associate professor at the College of Electronic and Optical Engineering & College of Microelectronic, NJUPT. Her research interests focus on biosensing and phototheranostics based on novel optoelectronic nanomaterials.

Feng Huang obtained his PhD degree in development biology from Fujian Normal University in 2015. He is now a lecture of Fujian Medical University. His current research interests include biological characteristics of nanomaterials and nanotechnology in diagnosis and treatment of tumors.

Peng Yu obtained his PhD degree from the University of Chinese Academy of Sciences in 2013, and was a research fellow in the research group of Professor Zheng Liu at Nanyang Technological University from 2014 to 2018. He is now an associate professor of “100 Top Talents Program” at Sun Yat-sen University. His research interests focus on nonlinear optical materials, high-performance electronic devices, and optoelectronic devices.

Zhimin Luo obtained his PhD degree in polymeric chemistry and physics at Fudan University under the supervision of Prof. Lianhui Wang in 2013, and worked as a research fellow in Prof. Hua Zhang’s group at Nanyang Technological University in Singapore from 2013 to 2018. He is now a professor at the Institute of Advanced Materials, NJUPT. He was honored as “Special Professors in Jiangsu Province”. His research interests focus on the synthesis of novel optoelectronic nanomaterials for biological and electrochemical applications.

Lianhui Wang obtained his PhD degree in polymeric chemistry and physics at Zhejiang University in 1998, and was a research fellow in Prof. E. T. Kang’s group at the National University of Singapore (NUS) from 1998 to 2000, followed by being an assistant professor at the Institute of Molecular and Cell Biology, NUS. Since June 2005, he joined the faculty of Fudan University as a professor and then moved to NJUPT in January 2011. Currently, he is a professor at the Institute of Advanced Materials, NJUPT. He was granted the funding of “National Distinguished Young Scholar” in 2004, and was honored as “Yangtze River Scholar Distinguished Professor” in 2011. His research group works on bioelectronics and nanobiology including the synthesis of optoelectronic nanomaterials and their applications for biochemical sensing, multimodal imaging, drug delivery and photothermo/chemo/photodynamic therapy.

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40843_2021_1633_MOESM1_ESM.pdf

Exfoliated FePS3 nanosheets for T1-weighted magnetic resonance imaging-guided near-infrared photothermal therapy in vivo

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Zhang, Y., Du, H., He, P. et al. Exfoliated FePS3 nanosheets for T1-weighted magnetic resonance imaging-guided near-infrared photothermal therapy in vivo. Sci. China Mater. 64, 2613–2623 (2021). https://doi.org/10.1007/s40843-021-1633-5

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