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Biocompatible CuO-decorated carbon nanoplatforms for multiplexed imaging and enhanced antitumor efficacy via combined photothermal therapy/chemodynamic therapy/chemotherapy

CuO修饰的碳纳米平台用于多重成像和联合增强的抗肿瘤治疗

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Abstract

Inspired by the limitations of nanoparticles in cancer treatment caused by their low therapeutic effects and biotoxicity, biocompatible and photothermal enhanced copper oxide-decorated carbon nanospheres (CuO@CNSs) with doxorubicin hydrochloride (DOX) loading were constructed. CNSs as photothermal agents were synthesized by a hydrothermal reaction. CuO was adsorbed on the surface of CNSs, which improved the photothermal conversion efficiency due to the electron transitions between C-2p and Cu-3d. In addition, CuO would release Cu2+ ions in the tumor microenvironment, which could produce hydroxyl radical (·OH) to induce cancer cells apoptosis via Haber-Weiss and Fenton-like reactions. DOX as a chemotherapeutic agent was located on the surface of CuO@CNSs by electrostatic adsorption and released quickly in the tumor microenvironment to kill cancer cells. The CuO@CNSs-DOX nanoplatforms realized the combination therapy of photothermal therapy (PTT), chemodynamic therapy (CDT), and chemotherapy (CT), which have strong potential for cancer treatment.

摘要

将多功能纳米平台的设计合成应用于肿瘤的联合治疗得到研究人员的广泛关注. 本研究通过水热法制备了形貌均匀的光热材料碳纳米球, 表面负载CuO和抗癌药盐酸阿霉素(DOX)实现光热/化学动力/化疗联合治疗. CuO通过静电吸附负载在碳纳米球(CNSs)表面, 电子在C-2p与Cu-3d之间的跃迁提高了材料的光热转换效率. CuO也可以作为化学动力试剂, 在肿瘤部位释放Cu2+并通过Haber-Weiss和类Fenton反应产生羟基自由基诱导肿瘤细胞凋亡. DOX吸附在CuO@CNSs表面, 表现出pH响应释放和近红外激光刺激响应的释放效果. 研究结果表明, CuO@CNSs-DOX纳米平台在体内外都有很好的抗癌效果, 在肿瘤治疗方面有很大的应用潜力.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (51720105015, 51672269, 51929201, 51922097, 51772124 and 51872282), the Science and Technology Cooperation Project between Chinese and Australian Governments (2017YFE0132300), the Science and Technology Development Planning Project of Jilin Province (20170101188JC and 20180520163JH), the Key Research Program of Frontier Sciences, CAS (YZDY-SSW-JSC018), the Youth Innovation Promotion Association of CAS (2017273), the Overseas, Hong Kong & Macao Scholars Collaborated Researching Fund (21728101), and the CAS-Croucher Funding Scheme for Joint Laboratories (CAS18204).

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Authors and Affiliations

  1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Fan Jiang  (姜帆), Binbin Ding  (丁彬彬), Yajie Zhao  (赵雅洁), Shuang Liang  (梁双), Ziyong Cheng  (程子泳), Ping’an Ma  (马平安) & Jun Lin  (林君)

  2. University of Science and Technology of China, Hefei, 230026, China

    Fan Jiang  (姜帆), Binbin Ding  (丁彬彬), Yajie Zhao  (赵雅洁), Shuang Liang  (梁双), Ziyong Cheng  (程子泳), Ping’an Ma  (马平安) & Jun Lin  (林君)

  3. School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, Singapore

    Bengang Xing  (邢本刚)

  4. Department of Otolaryngology Head and Neck Surgery, The Second Hospital, Jilin University, Changchun, 130041, China

    Bo Teng  (滕博)

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  1. Fan Jiang  (姜帆)
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  2. Binbin Ding  (丁彬彬)
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  9. Jun Lin  (林君)
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Contributions

Author contributions Jiang F performed the experiments and wrote the draft of manuscript; Ding B, Zhao Y and Liang S helped with the design of cell and animal experiments; Cheng Z, Xing B and Teng B provided suggestions and comments on the manuscript; Ma P and Lin J proposed the project and revised the manuscript.

Corresponding authors

Correspondence to Ping’an Ma  (马平安) or Jun Lin  (林君).

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Conflict of interest The authors declare that they have no conflict of interest.

Additional information

Fan Jiang received her BSc degree in chemistry from Zhengzhou University (ZZU) in 2017. She is currently a doctoral student under the supervision of Prof. Jun Lin at Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), and University of Science and Technology of China. Her research focuses on the development of inorganic nanoparticles for cancer therapy.

Ping’an Ma received his BSc degree in biology in 2005 and PhD degree in biochemistry in 2010, respectively, from Northeast Normal University. He is currently an assistant professor in Prof. Jun Lin’s group at CIAC, CAS. His research focuses on the synthesis and application of multifunctional inorganic nanoparticles for bioapplication, particularly the design and mechanism of platinum-based anticancer drugs.

Jun Lin received BSc and MSc degrees in inorganic chemistry from Jilin University in 1989 and 1992, respectively, and a PhD degree (inorganic chemistry) from CIAC, CAS in 1995. He is currently a professor at CIAC, CAS. His research interests include luminescent materials and multifunctional composite materials as well as their applications in display, lighting and biomedical fields.

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Biocompatible CuO-Decorated Carbon Nanoplatforms for Multiplexed Imaging and Enhanced Antitumor Efficacy via Combined Photothermal Therapy/Chemodynamic Therapy/Chemotherapy

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Jiang, F., Ding, B., Zhao, Y. et al. Biocompatible CuO-decorated carbon nanoplatforms for multiplexed imaging and enhanced antitumor efficacy via combined photothermal therapy/chemodynamic therapy/chemotherapy. Sci. China Mater. 63, 1818–1830 (2020). https://doi.org/10.1007/s40843-019-1397-0

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