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Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

建立一个生物腐蚀研究的标准化方法: 与体内腐蚀相关的体外镁腐蚀影响因素综述

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An Erratum to this article was published on 21 June 2018

This article has been updated

Abstract

The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

摘要

本文通过综述相关文献, 系统地评价了影响体外镁(Mg)腐蚀的因素. 分析了以下因素对镁体外生物腐蚀的影响: (i) 无机离子, 包括阴离子和阳离子, (ii) 有机成分, 如蛋白质、 氨基酸和维生素, (iii) 实验参数, 如温度、 pH值、 缓冲体系和流速. 通过这些归纳分析, 为建立一个体外生物腐蚀测试的标准化方法提供了思考和建议, 并推荐了几种有潜力的模拟体液. 实施实验参数的标准化方法具有显著减少体外生物腐蚀试验差异的潜能, 并有助于建立准确一致模拟体内腐蚀的方法. 然而, 在如何更好地表征体内环境和腐蚀机理上尚存在着知识上的空白. 本文审查了血浆是进行体外腐蚀测试的合适体液这一假设, 并提出在今后研究中需进一步考虑影响体内腐蚀机理的因素, 如样品封埋等.

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Change history

  • 21 June 2018

    In the version of this Review originally published in the April, 2018 issue of Sci China Mater (2018, 61: 475–500, https:// doi.org/10.1007/s40843-017-9173-7), the authors found a small error in Table 1. The corrected version of Table 1 appears below.

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Acknowledgements

This work was supported by the Australian Federal Government through an Australian Government Research Training Program Scholarship. We would also like to thank Dr. Zhiming Shi for his continued support and guidance. The authors would like to acknowledge the support of the Australian Research Council (ARC) (DP170102557 “Biodegradable magnesium alloy scaffolds for bone tissue engineering”). Finally, the Authors (in particular Dargusch M) would also like to gratefully acknowledge the support of the ARC Research Hub for Advanced Manufacturing of Medical Devices.

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Authors and Affiliations

  1. The University of Queensland, Materials Engineering Division, School of Mechanical & Mining Engineering, Brisbane, Qld, 4072, Australia

    Sean Johnston & Andrej Atrens

  2. The University of Queensland, Centre for Advanced Materials Processing and Manufacturing (AMPAM), Brisbane, Qld, 4072, Australia

    Matthew Dargusch

Authors
  1. Sean Johnston
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  2. Matthew Dargusch
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  3. Andrej Atrens
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Corresponding author

Correspondence to Andrej Atrens.

Additional information

Sean Johnston is a PhD student at the University of Queensland. His research interests are metallic biomaterials and biodegradable metals, with a specific focus on the corrosion of magnesium alloys in a medical environment.

Matthew Dargusch is a Professor of materials engineering at the University of Queensland. His research interests are in advanced manufacturing and the design and development of medical devices. He is the Director of the ARC Industrial Transformation Research Hub for Advanced Manufacturing of Medical Devices based at The University of Queensland.

Andrej Atrens is Professor of Materials Engineering at The University of Queensland. He received his PhD from the University of Adelaide in 1976 and his Doctor of Engineering from the University of Queensland in 1997. Prof. Atrens is a leading expert in the field of corrosion engineering. His research interests include Mg corrosion, biocorrosion of Mg for biodegradable medical implants, and hydrogen embrittlement of advanced high strength steels.

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Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

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Johnston, S., Dargusch, M. & Atrens, A. Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion. Sci. China Mater. 61, 475–500 (2018). https://doi.org/10.1007/s40843-017-9173-7

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