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A Review of Psychological, Social, and Behavioral Functions in the RASopathies

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Abstract

Aims

The aim of this review is to summarize research that has focused on psychological, social, and behavioral functions and outcomes across the RASopathies.

Methods

Empirical studies published in peer-reviewed, scientific journals over the past 32 years were identified through searches in PubMed, PsychInfo, and Google Scholar through July 23, 2019. Searches included the names of each of the RASopathies individually with one psychological search term. The authors reviewed all titles and abstracts for relevancy. Full-text articles of abstracts deemed relevant were then fully reviewed by the authors. Case studies were excluded.

Results

A total of 718 publications were identified through the initial search. Fifty-nine of these publications (8%) were deemed relevant after initial screening and fully reviewed by the authors.

Interpretation

There is a paucity of research on the psychological, social, and behavioral manifestations in children and adults with RASopathies, although an increase in research has emerged over the past 7 years. Dysfunction in these areas can negatively impact the individuals functioning with regard to relationships, education, employment, and quality of life. This review highlights the need for prospective research in these areas of functioning, with the ultimate goal of developing interventions and therapies targeting psychosocial impairments.

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Authors and Affiliations

  1. Division of Neuropsychology, Children’s National Hospital, 111 Michigan Avenue NW, Washington, DC, 20010, USA

    Karin S. Walsh, A. del Castillo & T. Kennedy

  2. Departments of Pediatrics and Psychiatry, George Washington University Medical Center, Washington, DC, USA

    Karin S. Walsh

  3. Premier Psychological Services, Houston, TX, USA

    A. I. Karim

  4. Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD, USA

    C. Semerjian

  5. Johns Hopkins University School of Medicine, Baltimore, MD, USA

    C. Semerjian

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  1. Karin S. Walsh
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  2. A. del Castillo
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  3. T. Kennedy
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  4. A. I. Karim
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Walsh, KS: Project creation, data collection and preparation, manuscript writing, overall supervision of project

del Castillo A: Data collection and preparation, manuscript writing

Kennedy T: Project planning, data collection and preparation

Karim AI: Data collection and preparation, manuscript writing

Semerjian C: Data collection and preparation, manuscript writing

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Correspondence to Karin S. Walsh.

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Walsh, K.S., del Castillo, A., Kennedy, T. et al. A Review of Psychological, Social, and Behavioral Functions in the RASopathies. J Pediatr Neuropsychol 6, 131–142 (2020). https://doi.org/10.1007/s40817-020-00088-1

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