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Cancer Stem Cell Division: Mathematical Models and Insights

  • Mathematical Models of Stem Cell Behaviour (M Kohandel and M Przedborski, Section Editors)
  • Published:
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Abstract

Purpose of Review

Tumors consist of heterogeneous cell types, which present challenges to effective therapeutics. This review intends to explore existing mathematical models to better understand the influence of these different types of cells on tumor growth and survival.

Recent Findings

Cancer stem cells are often the instigator of tumor development and drug resistance. The replenishment of the stem cells by other stem cells and progenitor cells impacts the efficacy of treatments. Multiple treatments are required to attack the multiple tumor cell types and induce remission. Mathematical models can be used to explore the behavior of these heterogeneous tumor cells, as well as predict the long-term efficacy of different therapies.

Summary

Cell division plays an integral role in the development of tumors. While mathematical models are generally robust, they must be updated frequently to accommodate the brisk pace of biological advances. Usable data to inform the models is scarce calling for better collaboration between these sciences to help advance the field of cancer therapeutics.

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    Authors and Affiliations

    1. Centre College, 600 W Walnut St, Danville, KY, 40422, USA

      Ellen R. Swanson

    2. St. Mary’s College of Maryland, St. Mary’s City, USA

      Samantha L. Elliott & Emek Kose

    3. St. Joseph’s College, New York City, USA

      Elizabeth A. Zollinger

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    1. Ellen R. Swanson
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    Correspondence to Ellen R. Swanson.

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    Swanson, E.R., Elliott, S.L., Zollinger, E.A. et al. Cancer Stem Cell Division: Mathematical Models and Insights. Curr Stem Cell Rep 7, 204–211 (2021). https://doi.org/10.1007/s40778-021-00199-1

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