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A Brief Review on Erythropoietin and Mesenchymal Stem Cell Therapies for Paediatric Neurological Disorders

  • Pre-clinical and Clinical Cellular Therapies (H.T. Spencer, Section Editor)
  • Published:
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Abstract

Purpose of Review

Paediatric neurological disorders (PNDs) are neurological conditions in infants resulting from injury to the developing nervous system. The neurodevelopmental sequelae in infants with neurological disorders occur from injury to a substantial part of the nervous system. The type of PNDs is classified based on the manifestations, signs and symptoms, and the neurologic core affected by the injury. However, the current prevalence of PNDs underlines the need for optimized and new treatment options.

Recent Findings

PNDs include, but are not limited to, neonatal stroke, cerebral palsy (CP), autism, paediatric status epilepticus (PSE) and spinal cord injury (SCI). Understanding the mechanisms underpinning neuronal necrosis in PNDs has led to the design and trial of potential therapies, including antioxidants, anticonvulsant drugs, mesenchymal stem cells (MSCs), hypothermia and erythropoietin (EPO). With those therapies and other treatment options for PNDs, a significant milestone in the care for children with PNDs has been achieved.

Summary

This review highlights the need for future pre-clinical and clinical studies to investigate a combination therapy of EPO and MSCs for PNDs.

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Authors and Affiliations

  1. Department of Anatomy, University of Otago, Dunedin, 9016, New Zealand

    Benjamin Emoefe Aghoghovwia & Onome Okpe

  2. Otago Medical School, University of Otago, Dunedin, 9016, New Zealand

    Emma Alex McIntyre

  3. Department of Human Anatomy and Cell Biology, Faculty of Basic and Medical Sciences, Delta State University, Abraka, Nigeria

    Enaohwo Mamerhi Taniyohwo

  4. Department of Oral Sciences, Faculty of Dentistry, University of Otago, Dunedin, 9016, New Zealand

    Jithendra Tharanga Ratnayake

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Aghoghovwia, B.E., Okpe, O., McIntyre, E.A. et al. A Brief Review on Erythropoietin and Mesenchymal Stem Cell Therapies for Paediatric Neurological Disorders. Curr Stem Cell Rep 7, 95–107 (2021). https://doi.org/10.1007/s40778-021-00189-3

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