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The Influence and Delivery of Cytokines and their Mediating Effect on Muscle Satellite Cells

  • Cell:Cell Interactions in Stem Cell Maintenance (D Bonnet, Section Editor)
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Abstract

Purpose of Review

Skeletal muscle satellite cells (SC) play an important role in the adaptation, repair, and maintenance of muscle. These resident muscle stem cells are regulated by a series of transcription factors known as myogenic regulator factors that orchestrate SC progression from the quiescent state through activation, proliferation, and differentiation, ultimately leading to the contribution of nuclei to muscle fibers. The purpose of this review was to provide an overview of the current state of knowledge on the role of cytokines in regulating muscle SC.

Recent Findings

Upstream effectors of the myogenic regulatory factors include growth factors and cytokines that can influence SC function through autocrine/paracrine signaling delivered via the microvasculature and general circulation, or through cell interactions with other muscle-resident cells and structures.

Summary

Recent evidence describing the relationship between capillaries and muscle SC highlights the importance of this anatomical relationship on SC function in response to physiological stimuli.

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Acknowledgements

Dr. Gianni Parise was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Grant (1455843), JP Nederveen by a NSERC Canadian Graduate Scholarship (CGS-D). We would like to thank Jessica Blackwood for her assistance in the preparation of the figures.

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Authors and Affiliations

  1. Department of Kinesiology, McMaster University, Hamilton, ON, L8S 4L8, Canada

    Joshua P. Nederveen, Sophie Joanisse, Tim Snijders & Gianni Parise

  2. Department of Medical Physics & Applied Radiation Sciences, McMaster University, Hamilton, ON, L8S 4L8, Canada

    Gianni Parise

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  1. Joshua P. Nederveen
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  2. Sophie Joanisse
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  3. Tim Snijders
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  4. Gianni Parise
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Correspondence to Gianni Parise.

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Conflict of Interest

Joshua P. Nederveen, Sophie Joanisse, Tim Snijders, and Gianni Parise declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

All procedures performed by the authors involving human participants were approved by the Hamilton Health Sciences Integrated Research Ethics Board, and conformed to the guidelines outlined in the Declaration of Helsinki. Participants gave their informed written consent prior to inclusion in the study. For animal studies performed by the authors, ethics approval was granted by the McMaster University Animal Research Ethics Board and conformed to the standards established by the Canadian Council on Animal Care.

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This article is part of the Topical Collection on Cell:Cell Interactions in Stem Cell Maintenance

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Nederveen, J.P., Joanisse, S., Snijders, T. et al. The Influence and Delivery of Cytokines and their Mediating Effect on Muscle Satellite Cells. Curr Stem Cell Rep 3, 192–201 (2017). https://doi.org/10.1007/s40778-017-0089-1

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