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Adaptive Human Behavior and Physiology

, Volume 5, Issue 2, pp 148–163 | Cite as

Experimentally-Induced Inflammation Predicts Present Focus

  • Jeffrey GassenEmail author
  • Anastasia Makhanova
  • Jon K. Maner
  • E. Ashby Plant
  • Lisa A. Eckel
  • Larissa Nikonova
  • Marjorie L. Prokosch
  • Gary W. Boehm
  • Sarah E. Hill
ORIGINAL ARTICLE

Abstract

Objective

Here, we provide an experimental test of the relationship between levels of proinflammatory cytokines and present-focused decision-making.

Methods

We examined whether increases in salivary levels of proinflammatory cytokines (interleukin-1β and interleukin-6) engendered by visually priming immunologically-relevant threats (pathogen threat, physical harm) and opportunities (mating) predicted temporal discounting, a key component of present-focused decision-making.

Results

As hypothesized, results revealed that each experimental manipulation led to a significant rise in both salivary interleukin-1β and interleukin-6. Moreover, post-manipulation levels of each cytokine independently predicted temporal discounting across conditions. These results were not moderated by pre-manipulation levels of either cytokine, nor were they found using the difference between pre- and post-manipulation levels of cytokines as a predictor.

Conclusions

Together, these results suggest that levels of proinflammatory cytokines may play a mechanistic role in the desire for immediately available rewards.

Keywords

Inflammation Life history theory Temporal focus Cytokines Impulsivity 

Notes

Funding

This project was supported by two National Science Foundation awards: BCS #1551201 awarded to S. E. Hill and BCS #1227089 awarded to J. K. Maner and L. A. Eckel.

Compliance with Ethical Standards

Conflicts of Interest

The authors declare that they have no conflict of interest.

Supplementary material

40750_2019_110_MOESM1_ESM.sav (13 kb)
ESM 1 (SAV 13 kb)

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Jeffrey Gassen
    • 1
    Email author
  • Anastasia Makhanova
    • 2
  • Jon K. Maner
    • 2
  • E. Ashby Plant
    • 2
  • Lisa A. Eckel
    • 2
  • Larissa Nikonova
    • 2
  • Marjorie L. Prokosch
    • 3
  • Gary W. Boehm
    • 1
  • Sarah E. Hill
    • 1
  1. 1.Department of PsychologyTexas Christian UniversityFort WorthUSA
  2. 2.Department of PsychologyFlorida State UniversityTallahasseeUSA
  3. 3.Department of PsychologyTulane UniversityNew OrleansUSA

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