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Adaptive Human Behavior and Physiology

, Volume 3, Issue 3, pp 212–220 | Cite as

From Oxytocin to Health: Exploring the Relationship between OXTR rs53576, Emotional Stability, Social Support, and Health

  • Amber Massey-AbernathyEmail author
ORIGINAL ARTICLE

Abstract

Individuals are often biologically predisposed for certain personality traits. In addition, those traits may enhance or diminish health and overall life satisfaction. One recent area of biological study has been the OXTR rs53576, which is a polymorphic site in the oxytocin receptor gene. OXTR rs53576 is reportedly related to sociality and social orientation. Specifically, homozygous G allele carriers often display more empathy and less stress reactivity, higher trust behaviors, more sensitive parenting or reactivity to infants’ cries and higher optimism and self-esteem. The current study investigates the association between OXTR rs53576 (GG genotype) and the personality trait of emotional stability. Genes may affect psychological tendencies, as well as phenotypical expressions and life outcomes related to these traits. The results of the current study suggest that the oxytocin polymorphism receptor rs53576 may be related to the personality trait emotional stability. Individuals with the G homozygous allele had higher scores in emotional stability. In addition, emotional stability was related to greater overall social support and general health. Taken together, it appears that individuals with OXTR rs53576 G homozygous alleles may have more emotional stability, increased social support and better health.

Keywords

OXTR rs53576 Emotional stability Social support Health 

References

  1. Altemus, M., Deuster, P. A., Galliven, E., Carter, C. S., & Gold, P. W. (1995). Suppression of hypothalamic-pituitary-adrenal axis responses to stress in lactating women. Journal of Clinical Endocrinology & Metabolism: Clinical and Experimental, 80, 2954–2959. doi: 10.1210/jc.80.10.2954.Google Scholar
  2. Andari, E., Schneider, F. C., Mottolese, R., Vindras, P., & Sirigu, A. (2014). Oxytocin's fingerprint in personality traits and regional brain volume. Cerebral Cortex, 24(2), 479–486. doi: 10.1093/cercor/bhs328.CrossRefGoogle Scholar
  3. Anderson, C., John, O. P., Keltner, D., & Kring, A. M. (2001). Who attains social status? Effects of personality and physical attractiveness in social groups. Journal of Personality and Social Psychology, 81(1), 116–132. doi: 10.1037/0022-3514.81.1.116.CrossRefGoogle Scholar
  4. Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2014). A sociability gene? Meta- analysis of oxytocin receptor genotype effects in humans. Psychiatric Genetics, 24(2), 45–51.CrossRefGoogle Scholar
  5. Barrick, M. R., & Mount, M. K. (2009). Select on conscientiousness and emotional stability. In: Locke, E. A. (2), Handbook of Principles of Organizational Behavior: Indispensable Knowledge for Evidence-Based Management (19–40). Location: Wiley.Google Scholar
  6. Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011). Social effects of oxytocin in humans: context and person matter. Trends in Cognitive Sciences, 15(7), 301–309.Google Scholar
  7. Belsky, J., Jaffee, S. R., Caspi, A., Moffitt, T., & Silva, P. A. (2003). Intergenerational relationships in young adulthood and their life course, mental health, and personality correlates. Journal of Family Psychology, 17(4), 460–471. doi: 10.1037/0893-3200.17.4.460.CrossRefGoogle Scholar
  8. Bernhard, R. M., Chaponis, J., Siburian, R., Gallagher, P., Ransohoff, K., Wikler, D., et al. (2016). Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment. Social Cognitive and Affective Neuroscience. doi: 10.1093/scan/nsw103.Google Scholar
  9. Bradley, B., Davis, T. A., Wingo, A. P., Mercer, K. B., & Ressler, K. J. (2013). Family environment and adult resilience: contributions of positive parenting and the oxytocin receptor gene. European Journal of Psychotraumatology, 4, 21659.CrossRefGoogle Scholar
  10. Brose, A., Scheibe, S., & Schmiedek, F. (2013). Life contexts make a difference: emotional stability in younger and older adults. Psychology and Aging, 28(1), 148–159. doi: 10.1037/a0030047.CrossRefGoogle Scholar
  11. Brouwer, C. M., Schilder, A. M., van Stel, H. F., Rovers, M. M., Veenhoven, R. H., Grobbee, D. E., et al. (2007). Reliability and validity of functional health status and health-related quality of life questionnaires in children with recurrent acute otitis media. Quality Of Life Research: An International Journal Of Quality Of Life Aspects Of Treatment, Care & Rehabilitation, 16(8), 1357–1373. doi: 10.1007/s11136-007-9242-0.CrossRefGoogle Scholar
  12. Buss, D. M. (2009). How can evolutionary psychology successfully explain personality and individual differences? Perspectives on Psychological Science, 4(4), 359–366.CrossRefGoogle Scholar
  13. Buss, D. M., & Schmitt, D. P. (1993). Sexual strategies theory: an evolutionary perspective on human mating. Psychological Review, 100(2), 204.CrossRefGoogle Scholar
  14. Carstensen, L. L. (1986). Social support among the elderly: limitations of behavioral interventions. The Behavior Therapist, 9(6), 111–113.Google Scholar
  15. Carter, C. S. (1998). Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology, 23(8), 779–818. doi: 10.1016/S0306-4530(98)00055-9.CrossRefGoogle Scholar
  16. Chen, F. S., Kumsta, R., von Dawans, B., Monakhov, M., Ebstein, R. P., & Heinrichs, M. (2011). Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans. PNAS Proceedings Of The National Academy Of Sciences Of The United States Of America, 108(50), 19937–19942. doi: 10.1073/pnas.1113079108.CrossRefGoogle Scholar
  17. Clarke, S., & Robertson, I. T. (2005). A meta-analytic review of the big five personality factors and accident involvement in occupational and non-occupational settings. Journal of Occupational and Organizational Psychology, 78(3), 355–376. doi: 10.1348/096317905X26183.CrossRefGoogle Scholar
  18. Cohen, S., & Wills, T. A. (1985). Stress, social support, and the buffering hypothesis. Psychological Bulletin, 98(2), 310–357. doi: 10.1037/0033-2909.98.2.310.CrossRefGoogle Scholar
  19. Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007). Oxytocin improves 'Mind-reading' in humans. Biological Psychiatry, 61(6), 731–733. doi: 10.1016/j.biopsych.2006.07.015.CrossRefGoogle Scholar
  20. Feldman, R., Weller, A., Zagoory-Sharon, O., & Levine, A. (2007). Evidence for a neuroendocrinological foundation of human affiliation: plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychological Science, 18(11), 965–970. doi: 10.1111/j.1467-9280.2007.02010.x.CrossRefGoogle Scholar
  21. Feldman, R., Gordon, I., Schneiderman, I., Weisman, O., & Zagoory-Sharon, O. (2010). Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent–infant contact. Psychoneuroendocrinology, 35(8), 1133–1141.CrossRefGoogle Scholar
  22. Feldman, R., Monakhov, M., Pratt, M., & Ebstein, R. P. (2016). Oxytocin pathway genes: Evolutionary ancient system impacting on human affiliation, sociality, and psychopathology. Biological Psychiatry, 79(3), 174–184.CrossRefGoogle Scholar
  23. Flinn, M. V. (2006). Evolution and ontogeny of stress response to social challenges in the human child. Developmental Review, 26(2), 138–174.CrossRefGoogle Scholar
  24. Gimpl, G., & Fahrenholz, F. (2001). The oxytocin receptor system: structure, function and regulation. Physiological Reviews, 81, 629–683.Google Scholar
  25. Goldberg, L. R. (1990). An alternative “description of personality”: the big five factor structure. Journal of Personality and Social Psychology, 59(6), 1216–1129.Google Scholar
  26. Gosling, S. D., Rentfrow, P. J., & Swann Jr., W. B. (2003). A very brief measure of the big five personality domains. Journal of Research in Personality, 37, 504–528.CrossRefGoogle Scholar
  27. Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010). Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biological Psychiatry, 67(7), 692–694. doi: 10.1016/j.biopsych.2009.09.020.CrossRefGoogle Scholar
  28. Hakulinen, C., Elovainio, M., Pulkki-Råback, L., Virtanen, M., Kivimäki, M., & Jokela, M. (2015). Personality and depressive symptoms: individual participant meta-analysis of 10 cohort studies. Depression and Anxiety, 32(7), 461–470. doi: 10.1002/da.22376.CrossRefGoogle Scholar
  29. Hays, R. D., Sherbourne, C. D., & Mazel, R. M. (1993). The RAND 36-item health survey 1.0. Health Economics, 2, 217–227. doi: 10.1002/hec.4730020305.CrossRefGoogle Scholar
  30. Hill, P., & Argyle, M. (2001). Emotional stability as a major dimension of happiness. Personality and Individual Differences, 31, 1357–1364. doi: 10.1016/S0191-8869(00)00229-4.CrossRefGoogle Scholar
  31. Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., et al. (2007). Oxytocin increases retention of social cognition in autism. Biological Psychiatry, 61(4), 498–503. doi: 10.1016/j.biopsych.2006.05.030.CrossRefGoogle Scholar
  32. Jang, K. L., Livesley, W. J., & Vernon, P. A. (1996). Heritability of the big five personality dimensions and their facets: a twin study. Journal of Personality, 64(3), 577–591. doi: 10.1111/j.1467-6494.1996.tb00522.x.CrossRefGoogle Scholar
  33. John, O. P., & Srivastava, S. (1999). The big five trait taxonomy: history, measurement, and theoretical perspectives. Handbook of Personality: Theory and Research, 2(1999), 102–138.Google Scholar
  34. Judge, T. A., Bono, J. E., Ilies, R., & Gerhardt, M. W. (2002). Personality and leadership: a qualitative and quantitative review. Journal of Applied Psychology, 87(4), 765–780. doi: 10.1037/0021-9010.87.4.765.CrossRefGoogle Scholar
  35. Karney, B. R., & Bradbury, T. N. (1995). The longitudinal course of marital quality and stability: a review of theory, methods, and research. Psychological Bulletin, 118(1), 3–34. doi: 10.1037/0033-2909.118.1.3.CrossRefGoogle Scholar
  36. Kim, H. S., Sherman, D. K., Sasaki, J. Y., Xu, J., Chu, T. Q., Ryu, C., et al. (2010). Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. PNAS Proceedings Of The National Academy Of Sciences Of The United States Of America, 107(36), 15717–15721. doi: 10.1073/pnas.1010830107.CrossRefGoogle Scholar
  37. Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435(7042), 673–676. doi: 10.1038/nature03701.CrossRefGoogle Scholar
  38. Krueger, F., Parasuraman, R., Iyengar, V., Thornburg, M., Weel, J., Lin, M., et al. (2012). Oxytocin receptor genetic variation promotes human trust behavior. Frontiers in Human Neuroscience, 6, 4. doi: 10.3389/fnhum.2012.00004.Google Scholar
  39. Le, H., Oh, I., Robbins, S. B., Ilies, R., Holland, E., & Westrick, P. (2011). Too much of a good thing: Curvilinear relationships between personality traits and job performance. Journal of Applied Psychology, 96(1), 113–133. doi: 10.1037/a0021016.CrossRefGoogle Scholar
  40. Li, J., Zhao, Y., Li, R., Broster, L. S., Zhou, C., & Yang, S. (2015). Association of oxytocin receptor gene (OXTR) rs53576 polymorphism with sociality: a meta-analysis. PloS One, 10(6), e0131820. doi: 10.1371/journal.pone.0131820.CrossRefGoogle Scholar
  41. McCrae, R. R., & Costa, P. T. (1994). The stability of personality: observation and evaluations. Current Directions in Psychological Science, 3(6), 173–175. doi: 10.1111/1467-8721.ep10770693.CrossRefGoogle Scholar
  42. McCrae, R. R., & Costa, P. J. (1997). Personality trait structure as a human universal. American Psychologist, 52(5), 509–516. doi: 10.1037/0003-066X.52.5.509.CrossRefGoogle Scholar
  43. McCrae, R. R., & John, O. P. (1992). An introduction to the five-factor model and its applications. Journal of Personality, 60(2), 175–215. doi: 10.1111/j.1467-6494.1992.tb00970.x.CrossRefGoogle Scholar
  44. Miller, G. F. (2007). Sexual selection for moral virtues. The Quarterly Review of Biology, 82(2), 97–125.CrossRefGoogle Scholar
  45. Ozer, D. J., & Benet-Martínez, V. (2006). Personality and the prediction of consequential outcomes. Annual Review of Psychology, 57, 401–421. doi: 10.1146/annurev.psych.57.102904.190127.CrossRefGoogle Scholar
  46. Ramanaiah, N. V., Detwiler, F. J., & Byravan, A. (1997). Life satisfaction and the five-factor model of personality. Psychological Reports, 80(3, Pt 2), 1208–1210. doi: 10.2466/pr0.1997.80.3c.1208
  47. Riem, M. E., Pieper, S., Out, D., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Oxytocin receptor gene and depressive symptoms associated with physiological reactivity to infant crying. Social Cognitive and Affective Neuroscience, 6(3), 294–300. doi: 10.1093/scan/nsq035.CrossRefGoogle Scholar
  48. Roberts, B. W., Caspi, A., & Moffitt, T. E. (2003). Work experiences and personality development in young adulthood. Journal of Personality and Social Psychology, 84(3), 582–593. doi: 10.1037/0022-3514.84.3.582.CrossRefGoogle Scholar
  49. Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. PNAS Proceedings Of The National Academy Of Sciences Of The United States Of America, 106(50), 21437–21441. doi: 10.1073/pnas.0909579106.CrossRefGoogle Scholar
  50. Saphire-Bernstein, S., Way, B. M., Kim, H. S., Sherman, D. K., & Taylor, S. E. (2011). Oxytocin receptor gene (OXTR) is related to psychological resources. PNAS Proceedings Of The National Academy Of Sciences Of The United States Of America, 108(37), 15118–15122. doi: 10.1073/pnas.1113137108.CrossRefGoogle Scholar
  51. Sapolsky, R. M. (2004). Social status and health in humans and other animals. Annual Review of Anthropology, 33, 393–418. doi: 10.1146/annurev.anthro.33.070203.144000.CrossRefGoogle Scholar
  52. Scourfield, J., Neilson, M., Lewis, G., & McGuffin, P. (1999). Heritability of social cognitive skills in children and adolescents. The British Journal of Psychiatry, 175, 559–564. doi: 10.1192/bjp.175.6.559.CrossRefGoogle Scholar
  53. Taylor, S. E., Gonzaga, G. C., Klein, L. C., Hu, P., Greendale, G. A., & Seeman, T. E. (2006). Relation of oxytocin to psychological stress responses and hypothalamic-pituitary-adrenocortical axis activity in older women. Psychosomatic Medicine, 68(2), 238–245. doi: 10.1097/01.psy.0000203242.95990.74.CrossRefGoogle Scholar
  54. Terracciano, A., Löckenhoff, C. E., Zonderman, A. B., Ferrucci, L., & Costa, P. J. (2008a). Personality predictors of longevity: activity, emotional stability, and conscientiousness. Psychosomatic Medicine, 70(6), 621–627. doi: 10.1097/PSY.0b013e31817b9371.CrossRefGoogle Scholar
  55. Terracciano, A., Löckenhoff, C. E., Crum, R. M., Bienvenu, O. J., & Costa, P. J. (2008b). Five- factor model personality profiles of drug users. BMC Psychiatry, 8, 22. doi: 10.1186/1471-244X-8-22.CrossRefGoogle Scholar
  56. Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., & … Meyer– Lindenberg, A. (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. PNAS Proceedings Of The National Academy Of Sciences Of The United States Of America, 107(31), 13936–13941. doi: 10.1073/pnas.1003296107
  57. Trivers, R. L. (1972). Parental investment and sexual selection (pp. 136–179). New York: Sexual Selection & the Descent of Man. Aldine de Gruyter.Google Scholar
  58. Trull, T. J., & Sher, K. J. (1994). Relationship between the five-factor model of personality and Axis I disorders in a nonclinical sample. Journal of Abnormal Psychology, 103(2), 350–360. doi: 10.1037/0021-843X.103.2.350.CrossRefGoogle Scholar
  59. Vittersø, J. (2001). Personality traits and subjective well-being: emotional stability, not extraversion, is probably the important predictor. Personality and Individual Differences, 31(6), 903–914. doi: 10.1016/S0191-8869(00)00192-6.CrossRefGoogle Scholar
  60. Zeigler-Hill, V., Holden, C. J., Enjaian, B., Southard, A. C., Besser, A., Li, H., & Zhang, Q. (2015). Self-esteem instability and personality: the connections between feelings of self-worth and the big five dimensions of personality. Personality and Social Psychology Bulletin, 41(2), 183–198. doi: 10.1177/0146167214559719.CrossRefGoogle Scholar
  61. Zimet, G. D., Dahlem, N. W., Zimet, S. G., & Farley, G. K. (1988). The multidimensional scale of perceived social support. Journal of Personality Assessment, 52(1), 30–41.CrossRefGoogle Scholar

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© Springer International Publishing 2017

Authors and Affiliations

  1. 1.Department of PsychologyMissouri State UniversitySpringfieldUSA

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