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Cardiac Arrest in Pediatric Cardiac ICUs: Prevention Comes First

  • Cardiology/CT Surgery (K Gist, Section Editor)
  • Published:
Current Treatment Options in Pediatrics Aims and scope Submit manuscript

Abstract

Purpose of Review

Cardiac arrest (CA) is a rare, but devastating complication in the pediatric cardiac ICU (CICU). Less than half of children that suffer CA in the CICU will survive, while survivors often suffer permanent neurologic injury. Despite monumental investment into improving the quality of CA resuscitation and post-arrest care, morbidity and mortality remain very high. Until recently, prevention of CA was deemed by many to not be feasible. Cohorts that are high risk for CA in the CICU will be discussed, and recent CA prevention efforts as a potential mechanism for improving outcomes in the CICU will be reviewed.

Recent Findings

Over the last couple of years, a few studies and quality improvement projects have emerged with exciting and provocative data suggesting that CA can be prevented in the pediatric ICU. Common themes of these studies include transparent identification of patients at high risk for CA and development of processes that foster shared situational awareness and communication among all bedside clinicians to recognize the pre-arrest phase and employ patient-specific deterioration mitigation plans, and/or rescue a patient from imminent arrest with a patient-specific dose of epinephrine available at the bedside.

Summary

Recent data suggests some CA in the CICU is preventable. CICU teams should be aware of the straightforward concepts of situational awareness for CA prevention and strongly consider adapting them for implementation in their CICUs. NO CPR is better than high-quality CPR.

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References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Alten, J., et al., Preventing cardiac arrest in the pediatric cardiac intensive care unit through multicenter collaboration. JAMA Pediatr, 2022. Multicenter study which implemented a cardiac arrest prevention bundle to reduce cardiac arrest in pediatric CICUs.

  2. Alten JA, et al. Epidemiology and outcomes of cardiac arrest in pediatric cardiac ICUs. Pediatr Crit Care Med. 2017;18(10):935–43. Specifically within pediatric cardiac ICUs, this study described the epidemiology and outcomes of cardiac arrests in this population.

  3. Andersen LW, et al. The prevalence and significance of abnormal vital signs prior to in-hospital cardiac arrest. Resuscitation. 2016;98:112–7.

    Article  Google Scholar 

  4. Berg MD, et al. In-hospital pediatric cardiac arrest. Pediatr Clin North Am. 2008;55(3):589-604,x.

    Article  Google Scholar 

  5. Berg RA, et al. Ratio of PICU versus ward cardiopulmonary resuscitation events is increasing. Crit Care Med. 2013;41(10):2292–7.

    Article  Google Scholar 

  6. Berg RA, et al. Incidence and outcomes of cardiopulmonary resuscitation in PICUs. Crit Care Med. 2016;44(4):798–808.

    Article  Google Scholar 

  7. Christ G, et al. Adverse cardiovascular effects of ketamine infusion in patients with catecholamine-dependent heart failure. Anaesth Intensive Care. 1997;25(3):255–9.

    Article  CAS  Google Scholar 

  8. de Caen AR, et al. Part 6: pediatric basic life support and pediatric advanced life support: 2015 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Circulation. 2015;132(16 Suppl 1):S177-203.

    Google Scholar 

  9. Dewan M, et al. Assessment of a situation awareness quality improvement intervention to reduce cardiac arrests in the PICU. Pediatr Crit Care Med. 2022;23(1):4–12. Single center study which implemented a situational awareness model in a general PICU to prevent cardiac arrests.

  10. Dhillon GS, Lasa JJ. Invited commentary: an ounce of prevention is worth a pound of cure: advancing the search for modifiable factors associated with cardiac arrest. World J Pediatr Congenit Heart Surg. 2022;13(4):482–4.

    Article  Google Scholar 

  11. Ferguson LP, et al. Reducing cardiac arrests in the PICU: initiative to improve time to administration of prearrest bolus epinephrine in patients with cardiac disease. Crit Care Med. 2020;48(7):e542–9. Single center study which showed decrease in cardiac arrests when bedside epinephrine was available to be used under certain conditions for high risk cardiac patients.

  12. Gupta P, et al. Impact of 24/7 in-hospital intensivist coverage on outcomes in pediatric intensive care. A multicenter study. Am J Respir Crit Care Med. 2016;194(12):1506–13.

    Article  Google Scholar 

  13. Gupta P, et al. Risk factors and outcomes of in-hospital cardiac arrest following pediatric heart operations of varying complexity. Resuscitation. 2016;105:1–7.

    Article  Google Scholar 

  14. Holmberg MJ, et al. Annual incidence of adult and pediatric in-hospital cardiac arrest in the United States. Circ Cardiovasc Qual Outcomes. 2019;12(7): e005580.

    Article  Google Scholar 

  15. Kronick SL, et al. Part 4: systems of care and continuous quality improvement: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2015;132(18 Suppl 2):S397-413.

    Google Scholar 

  16. Lasa JJ, et al. Critical care unit organizational and personnel factors impact cardiac arrest prevention and rescue in the pediatric cardiac population. Pediatr Crit Care Med. 2022;23(4):255–67.

    Article  Google Scholar 

  17. Lowry AW, et al. Cardiopulmonary resuscitation in hospitalized children with cardiovascular disease: estimated prevalence and outcomes from the kids’ inpatient database. Pediatr Crit Care Med. 2013;14(3):248–55.

    Article  Google Scholar 

  18. Ortmann L, et al. Outcomes after in-hospital cardiac arrest in children with cardiac disease: a report from get with the guidelines—resuscitation. Circulation. 2011;124(21):2329–37. Large study analyzing national cardiac arrests and comparing cardiac and non-cardiac patients.

  19. Riley CM, Murphy LD, Mastropietro CW. Cardiac arrest in children following cardiac surgery: a scoping review of contributing factors. World J Pediatr Congenit Heart Surg. 2022;13(4):475–81.

    Article  Google Scholar 

  20. Sprung J, et al. Effects of ketamine on the contractility of failing and nonfailing human heart muscles in vitro. Anesthesiology. 1998;88(5):1202–10.

    Article  CAS  Google Scholar 

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Correspondence to Jeffrey A. Alten MD.

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Jonathan J. Khoubian declares that he has no conflict of interest. Jeffrey A. Alten declares that he has no conflict of interest.

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Khoubian, J.J., Alten, J.A. Cardiac Arrest in Pediatric Cardiac ICUs: Prevention Comes First. Curr Treat Options Peds 8, 325–333 (2022). https://doi.org/10.1007/s40746-022-00255-w

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