Treatment tips and tricks
Treatment for streptococcal pharyngitis should be provided for children with symptoms that are compatible and who test positive for this pathogen. They should be treated with an antibiotic that has activity against GAS. The original clinical studies investigating the prevention of rheumatic fever used intramuscular penicillin [15]. Numerous other studies since then have been conducted with a variety of antibiotics. It has been presumed that a course of antibiotics which effectively eradicates the pathogen from the pharynx would also prevent the complication of rheumatic fever [11•].
It has been fortunate that while some Streptococcal species such as Streptococcus pneumoniae have developed resistance over time and require higher concentrations of penicillin to inhibit bacterial growth, S. pyogenes isolates have remained susceptible to penicillin [16–18]. In general, when treating a bacterial infection, it is preferable to use the most narrow spectrum antibiotic that will treat the infection. Penicillin is a narrow spectrum antibiotic which is an attractive option since it is well tolerated, has a low incidence of side effects, is inexpensive, and has proven efficacy in treating streptococcal pharyngitis. Amoxicillin, is also a narrow spectrum antibiotic, is often substituted for penicillin for younger children who prefer a more pleasant tasting liquid suspension. This is the current treatment recommendation from several groups including the following: the Infectious Disease Society of America, the American Academy of Pediatrics Committee on Infectious Disease, and the American Heart Association [10•, 11•, 12].
Dosing tip
Make it easy on yourself. Don’t pull out your calculator to determine what dose to prescribe. It takes very little penicillin to treat streptococcal pharyngitis, and penicillin has a large therapeutic index and therefore there is very little toxicity with higher doses. I try to keep things simple. I only use two doses for the treatment of children with GAS pharyngitis. If the patient is less than 27 kilograms (kg), (60 lbs) I prescribe penicillin or amoxicillin 250 mg (mg) twice a day for a duration of 10 days. If the child is greater than 27 kg (60 lbs), I prescribe 500 mg twice a day for 10 days duration. There is recent data to support once a day dosing of amoxicillin, and it has been recommended by the American Academy of Pediatrics Committee on Infectious Diseases as well as by the 2009 American Heart Association guidelines [10•, 12, 19, 20]. However, it is not approved by the Food and Drug Administration for children younger than 12 years of age. The bottom line—if it is easier for the family to administer amoxicillin once per day, then use 50 mg/kg (maximum dose of 1000 mg). This should only be prescribed if you are comfortable that the family will be adherent to a schedule of once a day dosing (see Table 1).
Table 1 Antibiotic dosages commonly used for treatment of streptococcal pharyngitis in children
What if the child is so sick that they cannot tolerate any oral medications?
The best alternative if the child is quite ill and cannot tolerate swallowing an oral medication or when it is anticipated that it will be a struggle to administer a daily antibiotic for 5 to 10 days, then the clinician should consider using benzathine penicillin G. This can be given as a one-time intramuscular dose. It will be slowly absorbed over time and will provide sufficient serum levels of antibiotic and effective therapy to treat streptococcal pharyngitis and to prevent rheumatic fever [15].
What if my patient is allergic to penicillin or amoxicillin?
For children who are allergic to amoxicillin or penicillin, who did not have anaphylaxis to these medications, a first-generation cephalosporin such as cephalexin can be prescribed. Numerous studies have shown the effectiveness of oral cephalosporins for the treatment of GAS pharyngitis (see Table 1) [21, 22]. Some studies have reported higher bacteriologic cure rates with the cephalosporins compared to the penicillins [21–23]. Because of this, some clinicians prefer to prescribe cephalosporins. However, it is important to note that the differences in bacteriologic success rates in some studies may be due to the inclusion of children who were GAS carriers rather than acutely infected children. It is known that cephalosporins are more effective at eradicating the carrier state when compared to penicillin [21, 22]. While there may be some advantages to the cephalosporins, they are more expensive, have a broader spectrum of activity, and in general have greater side effects than penicillin [23].
What about the macrolide antibiotics?
For children who had a severe allergic reaction to amoxicillin or penicillin, a macrolide antibiotic can be used. Azithromycin is more commonly used than erythromycin due to the gastrointestinal side effects seen with erythromycin. The advantage of using azithromycin is that you can prescribe 5 days of therapy. This is due to the pharmacokinetics and pharmacodynamics of this medication that provide a longer therapeutic effect. However, the dose of azithromycin that is recommended for treatment of streptococcal pharyngitis in children is 12 mg/kg given once a day with a maximum dose of 500 mg [24]. The commonly prescribed prepackaged azithromycin tablets contains 500 mg as a single dose on day 1, followed by 250 mg once daily on days 2 through 5. For a 20-kg child (44 lbs), this is double what is needed for the first day of therapy and it is the appropriate dose for days 2 through 5. Any child greater than 20 kg, who is prescribed this dose pack, will not receive the recommended 12 mg/kg on days 2 through 5. It is therefore my preference to use the suspension formulation for children less than 40 kg or to use 500 mg given once a day for 5 days for children greater than 40 kg.
Another important issue to remember when using the macrolide antibiotics is that there are several reports of communities who have observed high rates of macrolide-resistant organisms including GAS [25–27]. Recently, Logan et al. reported two children who presented with rheumatic fever, which was felt to be secondary to an infection with a macrolide-resistant isolate of GAS [28]. It is important to be aware of the resistance rates in your community.
What about using clindamycin?
Clindamycin is an alternative for treating GAS pharyngitis; it should be considered for the rare circumstance that a child is allergic to penicillin and it is known or suspected that the GAS is macrolide-resistant [29]. Clindamycin suspension is not pleasant tasting and is not well tolerated by younger children. Therefore, when prescribing this medication, I prefer to prescribe clindamycin capsules. The dose for treatment is 20–30 mg/kg/day divided in three doses (with a maximum dose of 300 mg). Dosage formulations of the capsules are as follows: 150 or 300 mg. For a child who cannot swallow capsules who is between 15 and 23 kg, I usually prescribe the 150-mg capsules which can be opened and the medication mixed with a small amount of applesauce. The 300-mg capsules can be used for children over 30 kg.
Approach to the child with multiple episodes of pharyngitis
Case presentation
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Sam is a 7-year-old boy who is in the second grade at school. It is March and he comes into the office with a sore throat and low-grade fever. He has no nasal congestion, cough, or rash. On examination, he has an erythematous pharynx and his tonsils are also erythematous and +2 in size without any exudate. He has anterior and posterior cervical adenopathy without overlying erythema and no skin findings. The remainder of his examination is within normal limits.
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Based on his history and physical examination, you decide to perform a streptococcal RADT and it is positive for GAS. His mother points out that this is his third episode of streptococcal pharyngitis this school year. You review his medical record and you note that he has had multiple visits for respiratory illnesses and had several RADTs performed. There were three tests which were positive for GAS. He was prescribed amoxicillin at an appropriate dose for all three episodes, and his mother states that he completed a 10-day course of therapy each time. His mother wants to know why he keeps getting strep throat.
First, it is important to establish if this child is more likely to be presenting with recurrent episodes of GAS pharyngitis or if he might be a GAS carrier. It is key to try to distinguish between the two because management of each is different. A positive RADT or culture for GAS at the time of acute pharyngitis does not prove that Sam has GAS pharyngitis. Proof of GAS pharyngitis would require following antibody titers, which is not practical in typical clinical care. Instead, it is essential to take a careful history of the symptoms that were present with each illness and to assess the child’s clinical response to the antibiotic therapy prescribed. The child with true recurrent episodes is most likely to have classic symptoms with each illness.
Children with pharyngitis due to GAS typically respond promptly with initiation of antibiotic therapy [13]. In contrast, children with a viral illness whose throat cultures are positive for GAS, who are GAS carriers, are less likely to have rapid improvement of their symptoms. While these clues are helpful, the best way to distinguish these two possibilities is to obtain a throat culture after the patient has completed therapy, at a time that they are without any symptoms. The child with true recurrent infections will have negative testing for GAS while the child who is a GAS carrier will have a positive throat culture at a time when they are well (see Table 2).
Table 2 Helpful hints to distinguish a child with true recurrent episodes of streptococcal pharyngitis from the child who is a streptococcal carrier
A patient with true recurrent episodes
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Sam completes his 10 days of amoxicillin and returns to your office 1 week later. He is well and completely back to normal. You obtain a bacterial throat culture, and it is negative for GAS. You determine that he is most likely having recurrent episodes of streptococcal pharyngitis. Now what do you advise this family?
In my experience, there are many children who are unfortunate enough to have several episodes of pharyngitis in one school year, especially boys in first and second grade. However, it is uncommon for a child to have multiple years with true recurrent episodes [4]. It is likely that some immunity develops over time as children become older and in addition, improve their hand hygiene which decreases transmission. Some clinicians recommend tonsillectomy for recurrent episodes of pharyngitis. However, the Infectious Disease Society of America guidelines do not recommend tonsillectomy as a way to prevent further episodes [11•]. This is supported by a study by Paradise et al. in which children were randomized to tonsillectomy versus observation for recurrent episodes of pharyngitis. He reported that while the children who had surgery had fewer episodes of pharyngitis in the 2 years post surgery compared to the non-surgical group, that benefit did not last. Both groups had fewer episodes each subsequent year [30]. In addition, surgery is associated with certain risks. Therefore, I advise these families, that if we can get them through the remainder of the current school year, then they will likely do well over the summer, when streptococcal pharyngitis is infrequent. After that, the odds are that they will do well the subsequent school year.
For the unusual child who has multiple [3, 4] documented true recurrent episodes of streptococcal pharyngitis in whom the family is considering tonsillectomy, I discuss with them the risks and benefits of daily amoxicillin prophylaxis until the end of the school year (late May) to prevent another episode. While the use of continuous antibiotic prophylaxis in general should be discouraged, due to the potential side effects and the ability to promote the development of bacterial resistance, it may incur fewer risks than surgery.
A patient who is a streptococcal carrier
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Let’s say that alternatively, Sam returns 1 week after completion of his 10-day course of antibiotic and his mother informs you that amoxicillin did not work very well. She reports that he remained ill for over a week. He is currently without any sore throat or respiratory symptoms. You obtain a bacterial throat culture, and it is positive for GAS. You determine that he is most likely a streptococcal carrier. Now what do you advise this family?
The positive culture for GAS at a time that the child is without symptoms likely indicates carriage of this organism in his pharynx. His recent illness was more likely to have been caused by a viral infection. Even without antibiotic treatment, fever and symptoms due to streptococcal pharyngitis will resolve quickly within several days of the onset of illness [14]. The persistence of symptoms beyond this time period is commonly observed in a child who has a viral infection who may be a carrier of GAS (and not an acute infection). It is difficult to know when he became a carrier. He may have had a true episode of streptococcal pharyngitis earlier in the year, and at some point, the GAS became one of the colonizing bacteria in his pharynx.
Children who are streptococcal carriers are not considered to be contagious and the GAS are simply colonizing the pharynx and are not causing disease. There is no immune response to the presence of the bacteria. In addition, these children are believed to be at little or no risk for developing suppurative or non-suppurative complications such as acute rheumatic fever [31].
The child who is a GAS carrier presents challenges in clinical management. Under most circumstances, antimicrobial therapy is not indicated for these children. However, the American Academy of Pediatrics Committee on Infectious Diseases suggests several situations when it may be advantageous to eradicate GAS colonization [10•]. These include when there is a family history of rheumatic fever, when the family is anxious or is considering surgery because of the GAS carriage, or when there are outbreaks of GAS pharyngitis [10•]. A review of the literature suggests that certain antimicrobial agents are associated with a higher likelihood for successful eradication [29–32]. However, there are only two studies whose primary outcome was to determine efficacy in eliminating GAS carriage. A ten-day course of oral clindamycin was found to be effective with successful eradication in 85–90 % of the children who were GAS carriers [29]. The second study demonstrated success with the combination of benzathine penicillin G and oral rifampin [32]. Common alternatives that are prescribed include a 10-day course of amoxicillin plus clavulanic acid, or a first-generation oral cephalosporin which can be prescribed for the child’s subsequent episode of pharyngitis with a positive throat swab for GAS in hope to eradicate the GAS [33] (see Table 3).
Table 3 Antibiotic dosages commonly used for eradication of the streptococcal carrier state in children