Synthesis, Characterization, Anti-corrosive/Anti-tumor Applications of a New Type Arylazo Compound 1,7-Bis(2-Hydroxy Phenyl)-4-(Phenyl Hydrazono)-Hepta-1,6-Diene-3,5-Dione
- 29 Downloads
The purpose of the study is to synthesize and characterize a new arylazo compound 1,7-bis(2-hydroxyphenyl)-4-(phenylhydrazono)hepta-1,6-diene-3,5-dione (HPHDD) . The corrosion inhibition behavior of the compound on mild steel in 1 M HCl was investigated using weight loss method, electrochemical impedance spectroscopy, and potentiodynamic measurements. The results revealed that this arylazo compound effectively inhibited the corrosion reaction in HCl medium. The surface analysis indicated that this inhibitor was strongly adsorbed on the metal surface. The electrochemical studies at different temperatures showed the thermal stability of the inhibitor. Quantum chemical studies were performed using DFT at the B3LYP/6-31G (d, p)basis set. Contrary to the carcinogenic property of usual anti-corrosive substances, the in vitro cytotoxic studies of the newly synthesized arylazo derivative against Dalton lymphoma ascites cells confirm the anti-tumor properties of the compound.
KeywordsCorrosion inhibitors Mild steel Polarization SEM In vitro cytotoxic studies
The authors are grateful to University Grant Commission for the funding for FDP, P.G., and Research Department of Chemistry, Christ College, Irinjalakuda, Calicut University, National Institute of Technology Trivandrum, CUSAT Cochin, and Amala Cancer Research Centre, Thrissur, Kerala.
Funding was provided by UGC-DAE Consortium for Scientific Research, University Grants Commission (IN) (Grant No. FIP/12 Plan/KLCA 020).
- 10.Chen S, Kar T (2012) Theoretical investigation of inhibition efficiencies of some schiff bases as corrosion inhibitors of aluminum. Int J Electrochem Sci 7:6265–6275Google Scholar
- 15.Noor Hasima, Bharat B, Aggarwal (2012) Cancer-linked targets modulated by Curcumin. Int J Biochem Mol Biol 3:328–351Google Scholar
- 18.Krishnankutty K, Basheer M, Kamalakshy D (2009) Arylazo derivatives of some fluorinated β-diketones and their metal complexes. J Iran Chem Res 2:111–119Google Scholar