Abstract
Purpose of Review
The objective of the study is to review the current methods of evaluating and managing both frostbite injury and non-thermal extremity vascular trauma, with an emphasis on endovascular techniques.
Recent Findings
The traditional management of frostbite has a well-established role for the rapid rewarming of injured tissues. This literature review highlights the evolution of the various management techniques with a specific focus on the more recent role of intra-vascular catheter-directed thrombolytic therapy. Non-thermal extremity trauma with resulting vascular injury requires prompt diagnosis that relies heavily on both the physical examination and the appropriate imaging.
Summary
Frostbite injury manifests as a progressive insult with distinct pathophysiologic phases during which imaging can guide appropriate care. Traditional medical management, in combination with intra-vascular catheter-directed thrombolytic regimens, can restore blood flow to poorly or non-perfused digits, thereby ultimately reducing the risk of delayed amputation. Non-thermal trauma to the extremities can result in a variety of vascular injuries. Interventional radiology plays a key role in diagnosis and an expanding role using transcatheter therapies in order to provide efficacious and optimal management of patients with vascular injury.
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References
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Handford C, Buxton P, Russell K, Imray C, McIntosh S, Freer L, et al. Frostbite: a practical approach to hospital management. Extrem Physiol Med. 2014;3:7. doi:10.1186/2046-7648-3-7.
Imray C, Grieve A, Dhillon S, Caudwell Xtreme Everest Research Group. Cold damage to the extremities: frostbite and non-freezing cold injuries. Postgrad Med J. 2009;85(1007):481–8. doi:10.1136/pgmj.2008.068635.
Reamy BV. Frostbite: review and current concepts. J Am Board Fam Pract. 1998;11(1):34–40. doi:10.3122/15572625-11-1-34.
Kroeger K, Janssen S, Niebel W. Frostbite in a mountaineer. Vasa. 2004;33:173. doi:10.1024/0301-1526.33.3.173.
Küpper T, Steffgen J, Jansing P. Cold exposure during helicopter rescue operations in the Western Alps. Ann Occup Hyg. 2003;47:7. doi:10.1093/annhyg/med008.
Petrone P, Kuncir EJ, Asensio JA. Surgical management and strategies in the treatment of hypothermia and cold injury. Emerg Med Clin North Am. 2003;21:1165. doi:10.1016/S0733-8627(03)00074-9.
Ingram BJ, Raymond TJ. Recognition and treatment of freezing and nonfreezing cold injuries. Curr Sports Med Rep. 2013;12(2):125–30. doi:10.1249/JSR.0b013e3182877454.
Valnicek SM, Chasmar LR, Clapson JB. Frostbite in the prairies: a 12-year review. Plast Reconstr Surg. 1993;92(4):633–41. doi:10.1097/00006534-199309001-00012.
• McIntosh SE, Opacic M, Freer L, Grissom CK, Auerbach PS, Rodway GW, et al. Wilderness Medical Society practice guidelines for the prevention and treatment of frostbite: 2014 update. Wilderness Environ Med. 2014;25(4 Suppl):S43–54. doi: 10.1016/j.wem.2014.09.001. This reference highlights the current practice guidelines for frostbite patients and reviews treatment options encompassing both in the field and hospital settings.
Murphy JV, Banwell PE, Roberts AH, McGrouther DA. Frostbite: pathogenesis and treatment. J Trauma. 2000;48(1):171–8. doi:10.1016/S0735-6757(01)80175-3.
Salimi Z, Wolverson MK, Herbold DR, Vas W. Frostbite: experimental assessment of tissue damage using Tc-99m pyrophosphate—work in progress. Radiology. 1986;161(1):227–31. doi:10.1148/radiology.161.1.3020608.
Heggers JP, Robson MC, Manavalen K, Weingarten MD, Carethers JM, Boertman JA, et al. Experimental and clinical observations on frostbite. Ann Emerg Med. 1987;16:1056–62. doi:10.1016/S0196-0644(87)80758-8.
Golant A, Nord RM, Paksima N, Posner MA. Cold exposure injuries to the extremities. J Am Acad Orthop Surg. 2008;16:704–15. doi:10.5435/00124635-200812000-00003.
McCauley RL, Hing DN, Robson MC, Heggers JP. Frostbite injuries: a rational approach based on the pathophysiology. J Trauma. 1983;23:143–7. doi:10.1016/S0196-0644(84)80589-2.
Millet JD, Brown RKJ, Levi B, Kraft CT, Jacobson JA, Gross MD, Wong KK. Frostbite: spectrum of imaging findings and guidelines for management. Radiographics. 2016;36:2154–69. doi:10.1148/rg.2016160045.
Kemp SS, Dalinka MK, Schumacher HR. Acroosteolysis: etiologic and radiological considerations. JAMA. 1986;255(15):2058–61. doi:10.1001/jama.1986.03370150100036.
Tishler JM. The soft-tissue and bone changes in frostbite injuries. Radiology. 1972;102(3):511–3. doi:10.1148/102.3.511.
Vinson HA, Schatzki R. Roentgenologic bone changes encountered in frostbite, Korea 1950–51. Radiology. 1954;63(5):685–95. doi:10.1148/63.5.685.
Ellis R, Short JG, Simonds BD. Unilateral osteoarthritis of the distal interphalangeal joints following frostbite: a case report. Radiology. 1969;93(4):857–8. doi:10.1148/93.4.857.
Cauchy E, Marsigny B, Allamel G, Verhellen R, Chetaille E. The value of technetium 99 scintigraphy in the prognosis of amputation in severe frostbite injuries of the extremities: a retrospective study of 92 severe frostbite injuries. J Hand Surg Am. 2000;25(5):969–78. doi:10.1053/jhsu.2000.16357.
Cauchy E, Chetaille E, Lefevre M, Kerelou E, Marsigny B. The role of bone scanning in severe frostbite of the extremities: a retrospective study of 88 cases. Eur J Nucl Med. 2000;27(5):497–502. doi:10.1016/j.remnie.2013.01.011.
Mehta RC, Wilson MA. Frostbite injury: prediction of tissue viability with triple-phase bone scanning. Radiology. 1989;170(2):511–4. doi:10.1148/radiology.170.2.2911677.
Zavadovskaia VD, Borodulin VG. Gamma scintigraphy in deep frostbite [in Russian]. Med Radiol (Mosk). 1981;26(2):8–10.
Ikawa G, dos Santos PA, Yamaguchi KT, Stroh-Recor C, Ibello R. Frostbite and bone scanning: the use of 99m-labeled phosphates in demarcating the line of viability in frostbite victims. Orthopedics. 1986;9(9):1257–61. doi:10.3928/0147-7447-19860901-17.
Santapau A, Razola P, Tardin L, Andrés A, Prats E, Banzo J. The role of bone scanning in severe frostbite of the feet in a mountaineer. Rev Esp Med Nucl Imagen Mol. 2013;32(2):113–4. doi:10.1016/j.remn.2012.01.009.
Smith D, Robson M, Heggers J. Frostbite and other cold-induced injuries. 2nd ed. St. Louis: C.V. Mosby; 1989.
Lewis RB, Walker WB, Pichotka J. The use of anticoagulant therapy in frostbite with special reference to heparin. Q Res Rep. 1948;60:21.
Kapur BM, Gulati SM, Talwar JR. Low molecular dextran in the management of frostbite in monkeys. Indian J Med Res. 1968;56:1675–81.
Welch GS, Gormly PJ, Lamb DW. Frostbite of the hands. Hand. 1974;6:33–9. doi:10.1016/0072-968X_74_90007-2.
•• Gonzaga T, Jenabzadeh K, Anderson C, Mohr W, Endorf F, Ahrenholz D. Use of intra-arterial thrombolytic therapy for acute treatment of frostbite in 62 patients with review of thrombolytic therapy in frostbite. J Burn Care Res. 2016;37:e323–34. doi:10.4103/0974-2700.99709. The above reference demonstrates that infusion of thrombolytic agents may partially or completely restore blood flow and minimize the risk of amputation in frostbite patients
Thom S. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg. 2011;127:131S–41S. doi:10.1097/PRS.0b013e3181fbe2bf.
von Heimburg D, Noah E, Sieckmann U, Pallua N. Hyperbaric oxygen treatment in deep frostbite of both hands in a boy. Burns. 2001;27:404–8. doi:10.1016/S0305-4179(00)00132-7.
Yeager RA, Campion TW, Kerr JC, Hobson RW, Lynch TG. Treatment of frostbite with intra-arterial prostaglandin E1. Am Surg. 1983;49:665–7.
Twomey JA, Peltier GL, Zera RT. An open-label study to evaluate the safety and efficacy of tissue plasminogen activator in treatment of severe frostbite. J Trauma. 2005;59(6):1350–1354; discussion 1354–1355. doi:10.1097/01.ta.0000195517.50778.2e.
Bruen KJ, Ballard JR, Morris SE, Cochran A, Edelman LS, Safe JR. Reduction of the incidence of amputation in frostbite injury with thrombolytic therapy. Arch Surg. 2007;142(6):546–551; discussion 551–553. doi:10.1001/archsurg.142.6.546.
Sheridan RL, Goldstein MA, Stoddard FJ Jr, Walker TG. Case records of the Massachusetts General Hospital. Case 41–2009. A 16-year-old boy with hypothermia and frostbite. N Engl J Med. 2009 Dec 31;361(27):2654–62. doi:10.1056/NEJMcpc0910088.
Wagner C, Pannucci CJ. Thrombolytic therapy in the acute management of frostbite injuries. Air Med J. 2011;30(1):39–44. doi:10.1016/j.amj.2010.08.006.
Johnson AR, Jensen HL, Peltier G, DelaCruz E. Efficacy of intravenous tissue plasminogen activator in frostbite patients and presentation of a treatment protocol for frostbite patients. Foot Ankle Spec. 2011;4:344–8. doi:10.1177/1938640011422596.
•• Tavri S, Ganguli S, Bryan R, Goverman J, Liu R, Irani Z, Walker T. Catheter-directed intraarterial thrombolysis as part of a multidisciplinary management protocol of frostbite injury. J Vasc Interv Radiol. 2016;27:1228–35. doi:10.1016/j.jvir.2016.04.027. The referenced article demonstrates the benefits of catheter-directed intraarterial tPA thrombolysis in frostbite patients limiting delayed amputation rates and that the degree of angiographic response has excellent predictive value for eventual outcomes.
Miller-Thomas MM, West OC, Cohen AM. Diagnosing traumatic arterial injury in the extremities with CT angiography: pearls and pitfalls. Radiographics. 2005;25:S133–42. doi:10.1148/rg.25si055511.
Gould J, Vedantham S. The role of Interventional radiology in trauma. Semin Interv Radiol. 2006;23:270–8. doi:10.1055/s-2006-948766.
Abou-Sayed H, Berger DL. Blunt lower-extremity trauma and popliteal artery injuries. Arch Surg. 2002;137:585–9. doi:10.1001/archsurg.137.5.585.
Dennis JW, Frykberg ER, Veldenz HC, Huffman S, Menawat SS. Validation of nonoperative management of occult vascular injuries and accuracy of physical examination alone in penetrating extremity trauma: 5- to 10-year follow-up. J Trauma. 1998;44:243–53. doi:10.1097/00005373-199802000-00001.
McCorkell SJ, Harley JD, Morishima MS, Cummings DK. Indications for angiography in extremity trauma. AJR Am J Roentgenol. 1985;145:1245–7. doi:10.2214/ajr.145.6.1245.
Kaufman JA, Parker JE, Gillespie DL, Greenfield AJ, Woodson J, Menzoian JO. Arteriography for proximity of injury in penetrating extremity trauma. J Vasc Interv Radiol. 1992;3:719–23. doi:10.1016/S1051-0443(92)72934-0.
Conrad MF, Patton JH, Parikshak M, Kralovich KA. Evaluation of vascular injury in penetrating extremity trauma: angiographers stay home. Am Surg. 2002;68:269–74.
Rieger M, Mallouhi A, Tauscher T, Lutz M, Jaschke WR. Traumatic arterial injuries of the extremities: initial evaluation with MDCT angiography. AJR Am J Roentgenol. 2006;186:656–64. doi:10.2214/AJR.04.0756.
Nicholson AA. Vascular radiology in trauma: a review. Cardiovasc Intervent Radiol. 2004;27:105–20. doi:10.1007/s00270-003-0031-z.
Maynar M, Baro M, Qian Z, Lopez Benitez R, Ragheb D, Llorens R, et al. Endovascular repair of brachial artery transaction associated with trauma. J Trauma. 2004;56:1336–41.
Homma H, Yukioka T, Ishimaru S, Fujikawa T, Sasaki H, Igarashi I, et al. Two-year follow-up after multiple injuries treated with endovascular stent-grafting of aorta and transcatheter arterial embolization of spleen: minimal invasive surgery for an elderly patient. J Trauma. 2002;52:382–6.
Brandt MM, Kazanjian S, Wahl WL. The utility of endovascular stents in the treatment of blunt arterial injuries. J Trauma. 2001;51:901–5.
Pfammatter T, Kunzli A, Hilfiker P, Schubiger C, Turina M. Relief of subclavian venous and brachial plexus compression syndrome caused by traumatic subclavian artery aneurysm by means of transluminal stent-grafting. J Trauma: Inj Infect Crit Care. 1998;45:972–4.
Althaus SJ, Keskey TS, Harker CP, Coldwell DM. Percutaneous placement of self-expanding stent for acute traumatic arterial injury. J Trauma. 1996;41:145–8.
Lyden SP, Srivastava SD, Waldman DL, Green RM. Common iliac artery dissection after blunt trauma: case report of endovascular repair and literature review. J Trauma. 2001;50:339–42. doi:10.1097/00005373-200102000-00024.
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Salloum, E., Tavri, S. & Gregory Walker, T. Frostbite, Injury, and Trauma in the Extremities. Curr Trauma Rep 3, 228–237 (2017). https://doi.org/10.1007/s40719-017-0098-7
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DOI: https://doi.org/10.1007/s40719-017-0098-7