Andersen ML, Tufik S. The effects of testosterone on sleep and sleep-disordered breathing in men: its bidirectional interaction with erectile function. Sleep Med Rev. 2008;12:365–79.
Becher EF, Bechara AJ. Making the diagnosis of erectile dysfunction. In: Contemporary Treatment of Erectile Dysfunction. New York: Humana Press; 2016. p. 71–83.
Tok A, Eminaga O, Burghaus L, Herden J, Akbarov I, Engelmann U, et al. Age-stratified cut-off points for the nocturnal penile tumescence measurement using nocturnal Electrobioimpedance volumetric assessment (NEVA®) in sexually active healthy men. Andrologia. 2016;48:631–6.
Zou ZJ, Chen ST, Ma GC, Lai YF, Yang XJ, Feng JR, et al. Consecutive nightly measurements are needed for accurate evaluation of nocturnal erectile capacity when the first-night laboratory recording is abnormal. Asian J Androl. 2020;22:94–9.
Schmidt MH. Sleep-related erection neurophysiology: a journey of discovery. Sleep Med. 2018;49:24–7.
Cohen SD. The challenge of erectile dysfunction Management in the Young man. Curr Urol Rep. 2015;16:84.
Schmidt MH. Impotence and erectile problems in sleep medicine. In: Sleep Medicine. New York: Springer; 2015. p. 457–63.
Avasthi A, Grover S, Sathyanarayana Rao TS. Clinical practice guidelines for Management of Sexual Dysfunction. Indian J Psychiatry. 2017;59(Suppl 1):S91–S115.
Le BV, Burnett AL. The future of erectile dysfunction therapy II: novel pharmacotherapy and innovative technology. In: Management of Sexual Dysfunction in men and women. New York: Springer; 2016. p. 109–21.
Tobaldini E, Costantino G, Solbiati M, Cogliati C, Kara T, Nobili L, et al. Sleep, sleep deprivation, autonomic nervous system and cardiovascular diseases. Neurosci Biobehav Rev. 2017;74:321–9.
McKinlay JB. The worldwide prevalence and epidemiology of erectile dysfunction. Int J Impot Res. 2000;12:S6–11.
Cho JW, Duffy JF. Sleep, sleep disorders, and sexual dysfunction. World J Mens Health. 2019;37:261–75.
Burschtin O, Wang J. Testosterone deficiency and sleep apnea. Sleep Med Clin. 2016;11:525–9.
Zhang XB, Lin QC, Zeng HQ, Jiang XT, Chen B, Chen X. Erectile dysfunction and sexual hormone levels in men with obstructive sleep apnea: efficacy of continuous positive airway pressure. Arch Sex Behav. 2016;45:235–40.
•• Shigehara K, Konaka H, Sugimoto K, Nohara T, Izumi K, Kadono Y, et al. Sleep disturbance as a clinical sign for severe hypogonadism: efficacy of testosterone replacement therapy on sleep disturbance among hypogonadal men without obstructive sleep apnea. Aging Male. 2018;21:99–105 Severe hypogonadism can have sleep disorders as a clinical sign. Testosterone replacement improves sleep quality and sexual function in hypogonadal men.
Tufik S, Santos-Silva R, Taddei JA, Bittencourt LR. Obstructive sleep apnea syndrome in the Sao Paulo epidemiologic sleep study. Sleep Med. 2010;11:441–6.
Liu L, Kang R, Zhao S, Zhang T, Zhu W, Li E, et al. Sexual dysfunction in patients with obstructive sleep apnea: a systematic review and meta-analysis. J Sex Med. 2015;12:1992–2003.
Chen CM, Tsai MJ, Wei PJ, Su YC, Yang CJ, Wu MN, et al. Erectile dysfunction in patients with sleep apnea--a Nationwide population-based study. PLoS One. 2015;10:e0132510.
Chen KF, Liang SJ, Lin CL, Liao WC, Kao CH. Sleep disorders increase risk of subsequent erectile dysfunction in individuals without sleep apnea: a nationwide population-base cohort study. Sleep Med. 2016;17:64–8.
Martin SA, Appleton SL, Adams RJ, Taylor AW, Vincent A, Brook NR, et al. Erectile dysfunction is independently associated with apnea-hypopnea index and oxygen desaturation index in elderly, but not younger, community-dwelling men. Sleep Health. 2017;3:250–6.
Kellesarian SV, Malignaggi VR, Feng C, Javed F. Association between obstructive sleep apnea and erectile dysfunction: a systematic review and meta-analysis. Int J Impot Res. 2018;30:129–40.
Seehuus M, Pigeon W. The sleep and sex survey: relationships between sexual function and sleep. J Psychosom Res. 2018;112:59–65.
Bozorgmehri S, Fink HA, Parimi N, Canales B, Ensrud KE, Ancoli-Israel S, et al. MrOS Study Association of Sleep Disordered Breathing with Erectile Dysfunction in Community Dwelling Older Men. J Urol. 2017;197:776–82.
Andersen ML, Guindalini C, Santos-Silva R, Bittencourt LR, Tufik S. Androgen receptor CAG repeat polymorphism is not associated with erectile dysfunction complaints, gonadal steroids, and sleep parameters: data from a population-based survey. J Androl. 2011a;325:524–9.
Li Z, Fang Z, Xing N, Zhu S, Fan Y. The effect of CPAP and PDE5i on erectile function in men with obstructive sleep apnea and erectile dysfunction: a systematic review and meta-analysis. Sleep Med Rev. 2019;48:101217.
Husnu T, Ersoz A, Bulent E, Tacettin O, Remzi A, Bulent A, et al. Obstructive sleep apnea syndrome and erectile dysfunction: does long term continuous positive airway pressure therapy improve erections? Afr Health Sci. 2015;15:171–9.
Li Z, Tang T, Wu W, Gu L, Du J, Zhao T, et al. Efficacy of nasal continuous positive airway pressure on patients with OSA with erectile dysfunction and low sex hormone levels. Respir Med. 2016;119:130–4.
Campos-Juanatey F, Fernandez-Barriales M, Gonzalez M, Portillo-Martin JA. Effects of obstructive sleep apnea and its treatment over the erectile function: a systematic review. Asian J Androl. 2017;19:303–10.
İrer B, Çelikhisar A, Çelikhisar H, Bozkurt O, Demir Ö. Evaluation of sexual dysfunction, lower urinary tract symptoms and quality of life in men with obstructive sleep apnea syndrome and the efficacy of continuous positive airway pressure therapy. Urology. 2018;121:86–92.
Jara SM, Hopp ML, Weaver EM. Association of Continuous Positive Airway Pressure Treatment with Sexual Quality of life in patients with sleep apnea: follow-up study of a randomized clinical trial. JAMA Otolaryngol Head Neck Surg. 2018;144:587–93.
Melehan KL, Hoyos CM, Hamilton GS, Wong KK, Yee BJ, McLachlan RI, et al. Randomized trial of CPAP and Vardenafil on erectile and arterial function in men with obstructive sleep apnea and erectile dysfunction. J Clin Endocrinol Metab. 2018;103:1601–11.
Pascual M, de Batlle J, Barbé F, Castro-Grattoni AL, Auguet JM, Pascual L, et al. Erectile dysfunction in obstructive sleep apnea patients: a randomized trial on the effects of continuous positive airway pressure (CPAP). PLoS One. 2018;13:e0201930.
•• Liu PY. A Clinical Perspective of Sleep and Andrological Health: Assessment, Treatment Considerations, and Future Research. J Clin Endocrinol Metab. 2019;104:4398–417 This study revealed that the vast majority of studies utilizing the gold standard International Index of Erectile Function (IIEF) show that CPAP therapy improves erectile function to a clinically meaningful degree.
• Schulz R, Bischof F, Galetke W, Gall H, Heitmann J, Hetzenecker A, et al. CPAP therapy improves erectile function in patients with severe obstructive sleep apnea. Sleep Med. 2019;53:189–94 Erectile dysfunction can at least partly be reversed by long-term CPAP therapy and is accompanied by improvements of quality of life.
Chung SD, Hung SH, Lin HC, Tsai MC, Kao LT. Obstructive sleep apnea and urological comorbidities in males: a population-based study. Sleep Breath. 2016;20:1203–8.
Santos-Silva R, Tufik S, Conway SG, Taddei JA, Bittencourt LR. Sao Paulo epidemiologic sleep study: rationale, design, sampling, and procedures. Sleep Med. 2009;10:679–85.
Andersen ML, Santos-Silva R, Bittencourt LR, Tufik S. Prevalence of erectile dysfunction complaints associated with sleep disturbances in Sao Paulo, Brazil: a population-based survey. J Sleep Medicine. 2010a;11:1019–24.
Jeon YJ, Yoon DW, Han DH, Won TB, Kim DY, Shin HW. Low quality of life and depressive symptoms as an independent risk factor for erectile dysfunction in patients with obstructive sleep apnea. J Sex Med. 2015;12:2168–77.
Melehan KL, Hoyos CM, Yee BJ, Wong KK, Buchanan PR, Grunstein RR, et al. Increased sexual desire with exogenous testosterone administration in men with obstructive sleep apnea: a randomized placebo-controlled study. Andrology. 2016;4:55–61.
Özkurt S, Akdağ B, Bolat D, Dursunoğlu N, Eskiçorapçı S, Kara CO. Sexual function in obstructive sleep apnea syndrome. Eur J Pulmonol. 2012;14:93–8.
Pastuszak AW, Moon YM, Scovell J, Badal J, Lamb DJ, Link RE, et al. Poor sleep quality predicts hypogonadal symptoms and sexual dysfunction in male nonstandard shift workers. Urology. 2017;102:121–5.
Soukhova-O'Hare GK, Schmidt MH, Nozdrachev AD, Gozal D. A novel mouse model for assessment of male sexual function. Physiol Behav. 2007;91:535–43.
Soukhova-O'Hare GK, Shah ZA, Lei Z, Nozdrachev AD, Rao CV, Gozal D. Erectile dysfunction in a murine model of sleep apnea. Am J Respir Crit Care Med. 2008;178:644–50.
Andersen ML, Guindalini C, Santos-Silva R, Bittencourt LR, Tufik S. Association analysis of endothelial nitric oxide synthase G894T gene polymorphism and erectile dysfunction complaints in a population-based survey. J Sex Med. 2010b;7:1229–36.
Andersen ML, Guindalini C, Santos-Silva R, Bittencourt LR, Tufik S. Angiotensin-converting enzyme polymorphism and erectile dysfunction complaints in the Brazilian population. J Sex Med. 2010c;7:2791–7.
Andersen ML, Alvarenga TA, Mazzotti DR, Guindalini C, Pellegrino R, Barrueco KF, et al. Hormonal profile, the PROGINS polymorphism, and erectile dysfunction complaints: data from a population-based survey. Fertil Steril. 2011b;95:621–4.
Andersen ML, Alvarenga TF, Mazaro-Costa R, Hachul HC, Tufik S. The association of testosterone, sleep, and sexual function in men and women. Brain Res. 2011;1416:80–104.
Guindalini C, Colugnati FA, Pellegrino R, Santos-Silva R, Bittencourt LR, Tufik S. Influence of genetic ancestry on the risk of obstructive sleep apnea syndrome. Eur Respir J. 2010;36:834–41.
Abuohashish HM, Ahmed MM, Sabry D, Khattab MM, Al-Rejaie SS. The ACE-2/Ang1-7/mas cascade enhances bone structure and metabolism following angiotensin-II type 1 receptor blockade. Eur J Pharmacol. 2017;807:44–55.
Fraga-Silva RA, Montecucco F, Mach F, Santos RA, Stergiopulos N. Pathophysiological role of the renin-angiotensin system on erectile dysfunction. Eur J Clin Investig. 2013;43:978–85. https://doi.org/10.1111/eci.12117.
Semet M, Paci M, Saïas-Magnan J, Metzler-Guillemain C, Boissier R, Lejeune H, et al. The impact of drugs on male fertility: a review. Andrology. 2017;5:640–63.
Matos G, Hirotsu C, Alvarenga TA, Cintra F, Bittencourt L, Tufik S, et al. The association between TNF-α and erectile dysfunction complaints. Andrology. 2013;1:872–8.