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Sleep Disturbance and Cancer—Animal Models

  • Sleep and Cancer (D Gozal, Section Editor)
  • Published:
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Abstract

Sleep-disordered breathing (SDB) has been linked to wide range of adverse physiologic and pathologic features, from cognitive impairments to increased risk of cancer. In this current review, we will discuss some of the emerging evidence connecting sleep disruption with cancer, by exploring different models of sleep disorders and how they appear to affect cancer. Then, we will summarize our current understanding of the underlying mechanisms, and finally, we will discuss the impact of sleep on one of the frequent and advanced cancer therapies, namely bone marrow transplantation (BMT). Experiments in animal models provide supportive findings, whereby each of the major components of SDB has begun to unravel their potential and complex effects on cancer biology, most likely via alterations in oxidative stress, angiogenesis, immune function, and sympathetic outflow. Future research is undoubtedly needed to better understand the pathophysiologic mechanisms of SDB-related effects on cancer in general, and more specifically on cancer prevention, treatment (chemotherapy, radiation, BMT), and outcomes.

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Authors and Affiliations

  1. Pediatric Pulmonary Division, Pediatric Pulmonary and CF Center, Ruth Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa, Israel

    Karin Yaacoby-Bianu & Fahed Hakim

  2. Cancer Research Center, Nazareth Hospital EMMS, Nazareth, Israel

    Fahed Hakim

  3. Rappaport Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel

    Fahed Hakim

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  1. Karin Yaacoby-Bianu
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Karin Yaacoby-Bianu and Fahed Hakim each declare no potential conflicts of interest.

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Yaacoby-Bianu, K., Hakim, F. Sleep Disturbance and Cancer—Animal Models. Curr Sleep Medicine Rep 3, 31–37 (2017). https://doi.org/10.1007/s40675-017-0073-4

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