Nightmares are a hallmark of posttraumatic stress disorder (PTSD). In the context of PTSD, nightmares are typically conceptualized as dysphoric dreams that completely or partially depict aspects of traumatic events. Nightmares are associated poor health and treatment outcomes such as poor sleep quality, daytime distress, and higher risk of suicide. Treatments targeting nightmares can also improve sleep and daytime symptoms of anxiety and depression.

In this article, we review the diagnostic criteria for nightmare disorder, recent studies on the content and characteristics and their relationship to functional outcomes, as well as new animal research that can inform our understanding of the pathophysiology underlying nightmares. New findings regarding established and novel psychological and pharmacological approaches for the treatment for nightmares with comorbid PTSD are also summarized here.

Diagnostic Criteria for Nightmare Disorder

The third edition of the International classification of sleep disorders (ICSD-3) [1, 2] has recently redefined nightmares as “repeated occurrences of extended, extremely dysphoric, and well-remembered dreams that usually involve threats to survival, security, or physical integrity” [1]. Contrary to several other parasomnias, the sleeper rapidly regains alertness and orientation upon awakening from a nightmare. Nightmare disorder is characterized by dysphoric dreams that perturb sleep consolidation and daytime functioning. While nightmares are developmentally common in young children, traumatic events and pharmacological agents are the most commonly identified precipitating factors in adults.

Nightmares are one of the re-experiencing symptoms of PTSD [3], and affect as many as 50 % of trauma-exposed adults. There is early evidence to suggest that men are more likely to experience nightmares as a symptom of PTSD than women. Males deployed in support of Operation Enduring Freedom (October, 2010) or Operation Iraqi Freedom (March, 2003) are more likely to experience nightmares, numbing, and hyper-vigilance than their female counterparts who experience more concentration problems and distress with reminders [4•]. Whether or not the same pattern holds in the civilian population or with nightmares without comorbid PTSD has yet be determined.

Content and Characteristics of Nightmares Comorbid with PTSD

Posttraumatic nightmares typically involve themes and sensory input related to a specific traumatic event. Harb and colleagues [5••] studied a sample of 48 combat-exposed Vietnam veterans to find a relationship between dream content and treatment outcomes of image rehearsal therapy (IRT), an intervention that promotes mastery over recurrent nightmares by rehearsing modified versions of the disturbing nightmare [6, 7]. Reports of olfactory experiences during original nightmares predicted a smaller reduction in sleep disturbances, possibly due to the link between odor perception and emotional memory. Harb and colleagues reasoned that experiencing smells may indicate intensity of a nightmare because of the rudimentary nature of the brain systems responsible for olfactory processing [5]. If that is the case, nightmare characteristics such as sensory experiences may inform patient prognosis.

Traumatic themes may also be subjected to cultural differences. Hinton and colleagues [8•] interviewed Cambodian refugees that survived and lost loved ones in the Pol Pot genocide (1975–1979) about the frequency, content, and meaning of dreams. While investigators did not refer to nightmares specifically, dreams described as “deeply upsetting” by all participants but one of the participants “awoke sobbing” paired with sadness and fear [8•]. In this cultural context, dreams themselves could be traumatic for the dreamer. When a deceased loved one appears in dreams, it means he or she is suffering and begging the dreamer for help [8•]. Such dreams could also be spiritual attack on the dreamer themselves that are thought to result in severe illness or death [8•]. The number of dreams in the past month correlated with PTSD symptom severity as measured by the PTSD checklist (r = −0.53, p < 0.01). More exploration into cultural differences in nightmare content is warranted because treatment approaches could be modified to meet the needs of patients.

Nightmares are not only associated with higher severity of PTSD symptoms at baseline as demonstrated in a study of 80 combat veterans by Pigeon et al. [9•]; nightmares may also predict higher PTSD severity at a six-month follow-up. In a study by Van Liempt et al. [10•], 453 Dutch soldiers were interviewed before and six months after a deployment to Afghanistan. Nightmares prior to deployment predicted PTSD at post deployment. Thus, targeting the treatment nightmares prior to or early after deployment offers a strategy to enhance resilience and/or mitigate the risk of poor deployment-related psychiatric symptoms and disorders.

Understanding the Pathophysiology of Nightmares Through Basic Research

Studying nightmares in the sleep laboratory or using sleep neuroimaging methods is highly challenging as these episodes cannot be reliably experimentally induced and rarely occur under laboratory conditions, even in individuals with chronic and frequent nightmares. Thus, animal models focused on the impact of trauma-like events on sleep and behaviors can provide some novel insights into the potential pathways underlying the pathophysiology of nightmares comorbid with PTSD.

One such study was conducted by Vanderheyden and colleagues [11••], and collected electroencephalogram (EEG) data before and after exposing rats to single prolonged stress, and measured freezing behaviors during a fear-learning task to determine PTSD-like symptom severity. They observed that an increase in REM sleep from baseline, and a reduction of sigma and theta waves in transition to REM was associated with increased freezing behavior during fear recall. Because nightmares are associated with an increase in REM sleep within eight hours of stress exposure, nightmares may interfere with fear extinction [11••]. When applied in a real world context, nightmares could exacerbate the development of PTSD symptoms or hinder PTSD treatment.

Bin Yu et al. [12••] sought to understand the differences in neural circuitry between rats that startled awake by assumed “nightmares” related to either physical trauma by a foot shocks, or psychological trauma by witnessing physical trauma. Twenty-one days after the initial trauma, the rats were put back in the communication box, without the foot shocks, after which, six hours of EEG was recorded. EEG analyzed one minute before the startled awakenings revealed higher delta power density and lower theta, alpha, and beta power density on the physically stressed rats while psychologically stressed rats had no changes in EEG analysis. Upon startled awakenings, animals were terminated and necropsies were performed. Neural circuits also differed between groups. Psychologically stressed rats experienced decreased activity in the granular and dysgranular insular cortex and increased activation in the temporal association cortex. Physically stressed rats displayed increases in the secondary somatosensory and primary auditory cortices. Both groups exhibited inactivation of the infralimbic prefrontal cortex and ventral anterior cingulate cortex with activation in the amygdala. These findings suggest that at least in animals, not only can the underlying mechanisms of PTSD and nightmares during sleep could be identified but also that they may differ depending on the type of trauma experienced [12••]. If types of trauma impact the brain differently, future studies should investigate the extent to which different types of trauma may be associated with distinct physiological correlates and treatment outcomes.

Treatment of Nightmares

Much improvement is still needed in rising awareness about the clinical relevance and the availability of effective nightmare treatments. Two recent surveys of over 1500 adults [13••] found that 7 % of respondents endorsed clinically significant nightmares, as defined by a score >10 on the disturbing dreams and nightmare severity index (DDNSI) [14], a questionnaire that measures frequency and intensity of nightmares, with scores of 10 or higher indicating a nightmare disorder [14]. Among adults who endorsed clinically significant nightmares, only 11 and 38 % reported that they had discussed nightmares with a healthcare provider. More importantly, only one-third of adults who endorsed clinically significant nightmares believed that nightmares were a treatable condition. The authors proposed that screening for nightmares in a more consistent manner among providers as well as education may improve utilization of evidence-based nightmare treatments, as well as mitigate the widespread belief that nightmares are not a treatable condition [13••].

Because nightmares are a symptom of PTSD and are often resistant to first-line PTSD treatments, much of the research in the last decade has targeted the treatment of nightmares comorbid with PTSD or trauma-related disorders. The impact of recommended psychological treatments of PTSD on nightmares and overall sleep quality has been more closely studies in recent years. The effectiveness of nightmare-focused treatments such as imagery rehearsal therapy and prazosin has also been re-evaluated in recent studies. Recent findings with psychological approaches and pharmacological agents are summarized below.

Psychological Treatments

Gutner and colleagues [15•] reported significant improvements in subjective sleep measures over the course of cognitive processing therapy, a treatment method that focuses on rectifying maladaptive emotional processing [16] and prolonged exposure, that uses imagined and in vivo exposure to facilitate fear extinction [17] in an intent to treat sample of 171 female victims of rape. Improvements were maintained at follow-up five to 10 years after treatment. While there was a clinically significant improvement in PTSD symptoms reported in an earlier publication [18], sleep disturbances did not reach full remission. Although daytime PTSD symptoms improved without full remission of sleep disturbances, healthy sleep improves quality of life, and treating nightmares and disturbed sleep should not be neglected.

Sloan et al. [19••] released a meta-analysis that reported the large effects (d = 0.71, 95 % CI [0.51, 0.91]) within group PTSD treatment compared to waitlist comparison (d = 0.56, 95 % CI [0.31, 0.82]) on PTSD symptoms. The 16 included publications were all between-condition randomized designs examining group treatment of PTSD in an outpatient sample over the age of 18. These effect sizes were similar to those reported by Casement and Swanson [20••]. Specifically, Casement and Swanson conducted a meta-analysis that included 13 studies published before July 30th, 2011 that focused on IRT or IRT and cognitive behavioral therapy for insomnia (CBTi). A majority of the studies used a group format with the number of sessions ranging from three to 10. IRT had a large effect on frequency of nightmares (ES = 0.69 95 % CI [0.50, 0.88]) sleep quality (ES = 0.68 95 % CI [0.34, 1.03]), and PTSD symptoms (ES = 0.72 95 % CI [0.54, 0.89]). IRT combined with CBT had significant improvement of sleep quality (p < 0.001) but not PTSD symptoms (p = 0.87) or nightmares (p = 0.13) [21••].

Schagen et al. [22•] studied nightmare reduction in a population with a range of psychiatric diagnoses. Participants were assigned to an IRT group or treatment as usual group. They found significant improvements across PTSD, anxiety, and depression in the IRT group at post-treatment, but only PTSD scores had significant improvements at a three-month follow-up whereas depression and anxiety did not. IRT shows potential in comorbidities such as anxiety and depression; however, the impact of treating nightmares has on PTSD symptomology speaks to the entwined nature of PTSD daytime symptoms and the traumatic nightmares that often accompany them.

While treating nightmares across psychiatric disorders seems promising, nightmares associated with PTSD present a unique set of challenges. Thunker et al. [23•] looked at the effectiveness of IRT in adults with nightmares and PTSD, depression, or no comorbidities. While IRT was effective across all three groups, the effect was less pronounced in the PTSD group. They speculate that this could be due to a higher number of nightmares at baseline or more psychological strain associated with PTSD and PTSD treatment.

In the Thunker et al. study [23•], the participants with PTSD were divided into IRT and TAU groups. The IRT group had a reduction in nightmare frequency but not in anxiety or number of awakenings. Thunker et al. hypothesize that the stressful nature of PTSD therapy may impact the effectiveness of IRT. Gehrman et al. [24••] observed that daytime stressors, theoretically such as stresses of treatment for PTSD, were associated with more nightmares, nightmare-related distress, and longer sleep onset latency on the nights that nightmares occurred. If treatment of PTSD interferes with the treatment of nightmares and vice versa as demonstrated in the above studies, the order of treatment administration should be considered.

In contrast, a study by Margolies et al. [25•] compared a group of post 9/11 veterans that received CBT with IRT to a waitlist group. While the treatment group improved in subjective and objective sleep measures, PTSD, depression, and distress, there was no change in nightmares. Margolies et al. speculated that this could be attributed to differences in a military population or possible non-compliance. Treatment adherence should be studied if IRT is to truly be considered effective.

Pharmacological Treatments of Nightmares

Alpha-1 Noradrenergic Antagonists

Although the etiology and pathophysiology of nightmares remain unknown, heightened noradrenergic tone during sleep and especially rapid-eye movement (REM) sleep has been proposed as a potential mechanisms underlying nightmares in the context of PTSD [26, 27].

Prazosin is an alpha-1 noradrenergic antagonist that crosses the blood brain barrier, and that may reduce nightmares and sleep disturbances that characterize PTSD [2731]. Based on the extensive review of open trials and placebo-controlled studies conducted in military veterans and civilians with nightmares PTSD, the American Academy of Sleep Medicine (AASM) recommended prazosin as an evidence-based treatment of nightmares, especially in the context of PTSD [32]; see also: [3335] for recent reviews.

Since the AASM recommendations were released in 2010, a number of randomized controlled trials have been conducted [3638], which have generally supported the effectiveness of prazosin for nightmares comorbid with PTSD. In a prazosin augmentation study conducted in active duty service members with combat-related nightmares and PTSD, Raskind and colleagues [37] showed clinically meaningful improvements in nightmares, sleep quality, PTSD severity, and overall functioning relative to placebo. In this trial, a mid-morning dose of up to 5 mg for men and 2 mg for women was augmented the bedtime dose (up to 20 mg for men and 10 mg for women), and improvements in daytime symptoms of hyperarousal, but not of re-experiencing, were also detected. Thus, prazosin may not only impact arousal during sleep but may also have benefits for daytime symptoms of PTSD or other arousal-related behaviors [3941].

Ahmadpanah and colleagues [36] conducted an eight-week randomized clinical trial to compare prazosin and hydroxyzine to a placebo condition on measures of nightmares, sleep quality, and PTSD symptom severity in sample of 100 adult civilians. Hydroxyzine is a histaminergic receptor blocker that has anxiolytic and sedative properties and may be effective in the treatment of anxiety disorders [42]. Both active treatments were associated with improvements in nightmares, overall sleep quality, and PTSD symptomatology, and the magnitude of improvements was slightly greater for the prazosin group.

Nirmalani-Gandhy and colleagues have described the cases of four combat veterans (three men and one woman) with chronic PTSD who failed a prazosin trial, but who showed improvements in nightmares with terazosin, another alpha-1 noradrenergic antagonist [43]. Effective terazosin doses ranged between 2 mg titrated up to 10 mg. In one patient, augmentation of nightly terazosin doses with morning dose of 2 mg improved symptoms of arousal. Of note, all four patients presented with comorbid psychiatric disorders and complex pharmacological profiles. This case series suggest that terazosin may offer a novel treatment approach for nightmares in the context of chronic PTSD, but controlled rigorous clinical trials in larger samples are required to establish the efficacy of terazosin.

Cannabis and Synthetic Endocannabinoids

The sedative, anxiolytic, and hypnotic effects of cannabis (Δ9-tetrahydrocannabinol or THC) have contributed to the growing medical or recreational use of cannabis to cope with PTSD symptoms, including nightmares, among trauma-exposed individuals [44]. Recent studies have found a positive association between cannabis use and severity of hyperarousal symptoms, including nightmares and sleep disturbances in veterans and civilian samples, e.g., [4547]. In a cross sectional study of 170 adult cannabis users, Bonn-Miller and colleagues [48] found that sleep disturbance was an independent predictor of recent cannabis use in adults with PTSD. Others have found that poor sleep quality predicted impeded reduction in cannabis use following a self-guided attempt to quit in a sample of veterans [49] or contribute to relapse [50]. Studies on impact effects of cannabis using objective sleep measure methods are scarce, and generally find that cannabis disrupts sleep continuity [47]. Similar, the efficacy of cannabis in the treatment of nightmares comorbid with PTSD remains scarcely investigated (see for review [51]). Of note, different strains of cannabis may differentially impact nightmares and insomnia comorbid with PTSD [44].

There is some preliminary evidence that the synthetic endocannabinoid receptor agonist, nabilone, a cannabinoid 1 (CB1) that is FDA-approved for chemotherapy-related side effects, may be effective to reduce nightmares in PTSD. Although nabilone has a profile similar to tetrahydrocannabinol (THC), it does not have the euphoric effects of cannabis. The use nabilone in PTSD is not new: Fraser [52] reported significant reduction or cessation of PTSD-related nightmares in Canadian soldiers with nightly doses of nabilone ranging between 0.2 and 4 mg. Like prazosin, discontinuation of nabilone can be associated with a recurrence of nightmares. Reductions in nightmares were associated with improvements in sleep quality and reduction in daytime re-experiencing symptoms. Reported side effects are generally minor and can include dizziness, lightheadedness, forgetfulness, and headache.

In a retrospective chart review, Cameron and colleagues recently [53] reported significant reduction in the number of nights with nightmares as well as overall improvements in sleep quality, daytime PTSD symptom severity, and overall functional in a sample of 90 inmates. Improvements in nightmares and sleep quality were rapidly detected (<2 weeks) and maintained over time. The potential benefits of nabilone for the treatment nightmares comorbid with PTSD was recently further highlighted in a double-blind, placebo-controlled cross-over study conducted by Jetly and colleagues [54] in a small sample of ten service members with PTSD. Compared to placebo, nabilone was associated with significant reductions in nightmare severity and improved overall PTSD symptom severity. In this trial, benefits were observed as doses between 0.5 and 3 mg, and the medication was well tolerated. Published reports to date suggest that nabilone is well tolerated at doses that range between 0.5 and 4 mg, and that common side effects include dizziness, headaches, dry month, and lightheadedness. One case of psychosis has been reported [53].


Nightmares are an underestimated sleep disorder and are a core feature of PTSD that requires targeted assessment and treatment. The recent changes and broadening of the diagnostic for nightmare disorder raise the possibility that nightmares comorbid with PTSD may also include a wider range of dysphoric content than the strict focus on trauma-related dreams currently stated for the diagnosis of PTSD. The content of nightmares comorbid with PTSD has yet to be fully investigated in large samples using prospective dream sampling methods. While a detailed content analysis may not be necessary for diagnosis or treatment of nightmares in PTSD, such analysis may provide novel directions for treatment options and underlying cognitive mechanisms.

Nevertheless, case reports and clinical trials focused on the treatment of nightmares have been consistent in recent years. These reports have mainly focused on the recommended and novel treatment approaches, within more heterogeneous samples including individuals with psychiatric comorbidities or varying forms of trauma. Nevertheless, treatment studies have generally been limited by the lack of data regarding participant adherence to treatment recommendations. Although the progress in psychological treatment options has been encouraging, no novel methods have been introduced. Novel pharmacological agents, including terazosin and synthetic endocannabinoid agents, may offer new treatments to target nightmares comorbid with PTSD. Larger randomized controlled trials are required to fully determine safety and efficacy.