In the early twentieth century, Tatsuo Aida in Japan, Øjvind Winge in Denmark, Richard Goldschmidt in Germany, and Calvin Bridges in the United States all developed different experimental systems to study the genetics of sex reversal. These locally specific experimental systems grounded these experimenters’ understanding of sex reversal as well as their interpretation of claims regarding experimental results and theories. The comparison of four researchers and their experimental systems reveals how those different systems mediated their understanding of genetic phenomena, and influenced their interpretations of sex reversal.
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By using anthropomorphic language of excitation, Aida’s understanding of sex chromosomes appears to be a case of what Sara Richardson calls “Sexing the X,” where human characteristics are ascribed to the X and Y chromosomes (Richardson 2011).
Ha’s “The Riddle of Sex” convincingly demonstrates the importance of hormonally based understandings of sex at this time. For present purposes, I have focused on a narrower set of genetic experiments and their interpretation.
Aida, T. (1921). On the inheritance of color in a fresh-water fish, Aplocheilus latipes Temmick and Schlegel, with special reference to sex-linked inheritance. Genetics, 6, 554–573.
Aida, T. (1930). Further genetical studies of Aplocheilus latipes. Genetics, 15, 1–16.
Aida, T. (1936). Sex reversal in Aplocheilus latipes and a new explanation of sex-differentiation. Genetics, 21, 136–153.
Allen, G. (1974). Opposition to the mendelian-chromosome theory: The physiological and developmental genetics of Richard Goldschmidt. Journal of the History of Biology, 7, 49–92.
Allen, G. (1978). Thomas Hunt Morgan, the Man and His Science. Princeton: Princeton University Press.
Allen, G. (1980). The historical development of the “Time Law of Intersexuality” and its philosophical implications. In P. Leonie (Ed.), Richard Goldschmidt: Controversial geneticist and creative biologist, experientia supplementum (Vol. 35, pp. 41–48).
Allen, G. (1986). T H Morgan and the split between embryology and genetics, 1910–1935. In T. Horder, et al. (Eds.), History of Embryology (pp. 113–146). Cambridge: Cambridge University Press.
Bateson, W. (1908). The methods and scope of genetics. Cambridge: Cambridge University Press.
Bridges, C. (1916). Non-disjunction as proof of the chromosome theory of heredity. Genetics, 1, 1–52.
Bridges, C. (1922). The origin of variations in sexual and sex-limited characters. The American Naturalist, 56, 51–63.
Bridges, C. (1939). Cytological and genetic basis of sex. Sex and Internal Secretions (2nd ed., pp. 15–63). Baltimore: Johns Hopkins University Press.
Brush, S. (2002). How theories became knowledge: Morgan’s chromosome theory of heredity in America and Britain. Journal of the History of Biology, 35, 471–535.
Clarke, A. (1998). Disciplining reproduction: Modernity, American Life Sciences, and “the Problems of Sex”. Berkeley: University of California Press.
Crew, F. A. E. (1933). Sex determination. London: Methuen.
Davis, G., Dietrich, M., & Jacobs, D. (2009). Homeotic mutants and the assimilation of developmental genetics into the evolutionary synthesis. In Joe Cain & Michael Ruse (Eds.), Descended from Darwin: Insights into American Evolutionary Studies, 1900–1970 (pp. 133–154). Philadelphia: American Philosophical Society.
Dietrich, M. (1995). Richard Goldschmidt’s “heresies” and the evolutionary synthesis. Journal of the History of Biology, 28, 431–461.
Dietrich, M. (1996). On the mutability of genes and geneticists: The “Americanization” of Richard Goldschmidt and Victor Jollos. Perspectives on Science, 4, 321–345.
Dietrich, M. (2000a). Of moths and men: Theo Lang and the persistence of Richard Goldschmidt’s theory of the genetics of homosexuality, 1916–1960. History and Philosophy of the Life Sciences, 22, 217–245.
Dietrich, M. (2000b). From hopeful monsters to homeotic effects: Richard Goldschmidt’s integration of development, evolution, and genetics. American Zoologist, 40, 28–37.
Dietrich, M. (2000c). The problem of the gene. Comptes Rendus de l’Académie des Sciences de Paris, 323, 1139–1146.
Dietrich, M. (2000d). From gene to genetic hierarchy: Richard Goldschmidt and the problem of the gene. In P. Beurton, R. Falk, & H. Rheinberger (Eds.), The concept of the gene in development and evolution. Cambridge: Cambridge University Press.
Dietrich, M. (2008). Striking the hornet’s nest: Richard Goldschmidt’s rejection of the particulate gene. In O. Harman & M. R. Dietrich (Eds.), Rebels, mavericks, and heretics in biology (pp. 119–136). New Haven, CT: Yale University Press.
Dietrich, M. (2011). Reinventing Richard Goldschmidt: Reputation, memory, and biography. Journal of the History of Biology, 44, 693–712.
Gilbert, S. (1978). The embryological origins of the gene theory. Journal of the History of Biology, 11, 307–351.
Gilbert, S. (1988). Cellular politics: Ernest everett just, Richard B. Goldschmidt and the attempt to reconcile embryology and genetics. In R. Rainger, K. Benson, & J. Maienschein (Eds.), The American development of biology (pp. 311–346). New Brunswick: Rutgers University Press.
Goldschmidt, R. (1911). Über die Vererbung der sekundären Geschlechtscharaktere. Sitzungberichte der Gesellschaft fur Morphologie und Physiologie in München, 27, 115–118.
Goldschmidt, R. (1916). Experimental intersexuality and the sex problem. American Naturalist, 50, 705–718.
Goldschmidt, R. (1920). Einführung in die Vererbungswissenschaft (3rd ed.). Leipzig: W. Engelmann.
Goldschmidt, R. (1923). The mechanism and physiology of sex determination. William Dakin, trans. London: Methuen and Co.
Goldschmidt, R. (1927a). Physiologische theorie der vererbung. Berlin: Springer.
Goldschmidt, R. (1927b). Die zygotischen sexuellen Zwischenstufen und die Theorie der Geschlechtsbestimmung. Ergebnisse der Biologie, 2, 554–684.
Goldschmidt, R. (1931). Die sexuellen Zwischenstufen. Berlin: JSpringer.
Goldschmidt, R. (1934). Lymantria. Bibliographia Genetica, 111, 1–185.
Goldschmidt, R. (1937). A critical review of some recent work in sex determination. I. Fishes. The Quarterly Review of Biology, 12, 426–439.
Goldschmidt, R. (1938). Physiological genetics. New York: McGraw-Hill.
Goldschmidt, R. (1940). The material basis of evolution. New Haven: Yale University Press.
Goldschmidt, R. (1942). Sex-determination in Melandrium and Lymantria. Science, 95, 120–121.
Goldschmidt, R. (1950). Fifty years of genetics. American Naturalist, 84, 313–339.
Goldschmidt, R. (1960). In and out of the ivory tower. Seattle: University of Washington Press.
Ha, N. (2011). The riddle of sex: Biological theories of sexual difference in the early twentieth-century. Journal of the History of Biology, 44, 505–546.
Harwood, J. (1993). Styles of scientific thought: the german genetics community, 1900–1933. Chicago: University of Chicago Press.
Herrn, R. (1995). On the history of biological theories of homosexuality. In J. De Cecco & D. Parker (Eds.), Sex, cells, and same sex attraction (pp. 31–56). New York: Haworth Press.
Hopwood, N. (2011). Approaches and species in the history of vertebrate embryology. Methods in Molecular Biology, 770, 1–20.
Hori, H. (2011). A glance at the past of medaka fish biology. In K. Naruse, M. Tanaka, & H. Takeda (Eds.), Medaka: A model for organogenesis, human disease, and evolution (pp. 1–16). Dordrecht: Springer.
Iida, K. (2009). Practice and politics in Japanese science: Hitoshi Kihara and the formation of genetics as a discipline. Journal of the History of Biology, 43, 529–570.
Iida, K. (2015). Genetics and “Breeding as a Science”: Kihara Hitoshi and the Development of genetics in Japan in the first half of the twentieth century. In D. Philips & S. Kingsland (Eds.), New perspectives on the history of the life sciences and agriculture (pp. 439–458). New York: Springer.
Ishiwara, M. (1917). Medaka no taishoku no iden ni tsuite (On the inheritance of body colors in the medaka, Oryzias latipes). Mitteilungen aus der medizinischen Fakultät Kyushu, 4, 43–51.
Kingsland, S. (2009). Maintaining continuity through a scientific revolution: A rereading of E. B. Wilson and T. H. Morgan on sex determination and Mendelism. Isis, 98, 468–488.
Kinoshita, M., Murata, K., Naruse, K., & Tanaka, M. (2009). History and Features of Medaka., Medaka: Biology, management, and experimental protocols Ames, IA: Wiley.
Klöppel, U. (2010). XX0XY ungelöst. Hermaphroditismus, Sex und Gender in der deutschen Medizin. Eine historische Studie zur Intersexualität. Bielefeld: Transcript.
Kohler, R. (1993). Drosophila: A life in the laboratory. Journal of the History of Biology, 26, 281–310.
Kohler, R. (1994). Lords of the fly: Drosophila genetics and the experimental life. Chicago: University of Chicago Press.
Komai, T. (1958). Tatuo Aida, Geneticist. Science, 127, 1327.
Littlefield, C. L. & Bryant, P. J. (1980). Views on sex determination, In Leonie P (Ed.) Richard Goldschmidt: Controversial geneticist and creative biologist, Experientia Supplementum 35, (pp 49–63)
Maienschein, J. (1984). What determines sex?: A study of converging approaches. Isis, 75, 457–480.
Maienschein, J. (1991). Transforming traditions in American Biology, 1880–1915. Baltimore: Johns Hopkins University Press.
Morgan, T. (1910). Sex limited inheritance in Drosophila. Science, 32, 120–122.
Morgan, T. (1926). Results relating to chromosomes and genetics. The Quarterly Review of Biology, 1, 186–211.
Morgan, T. (1939). Calvin Blackman Bridges. Science, 89, 118–119.
Morgan, T. (1940). Biographical Memoir of Calvin Blackman Bridges, 1889–1938. Biographical Memoirs of the National Academy of Sciences, 22, 29–48.
Onaga, L. (2015). More than metamorphosis: The silkworm experiments of Toyama Kametaro and his cultivation of genetic thought in Japan’s sericultural practices, 1894–1918. In D. Philips & S. Kingsland (Eds.), New perspectives on the history of the life sciences and agriculture (pp. 415–437). New York: Springer.
Oudshoorn, N. (1994). Beyond the natural body: An archeology of sex hormones. New York, NY: Routledge.
Pueckert, D. (1987). The Weimar Republic: The Crisis of Classical Modernity. New York: Hill and Wang.
Rheinberger, H.-J. (1992a). Experiment, difference, and writing: I. Tracing protein synthesis. Studies in the History and Philosophy of Science, 23, 305–331.
Rheinberger, H.-J. (1992b). Experiment, Difference, and Writing: II. The Laboratory Production of Transfer RNA. Studies in the History and Philosophy of Science, 23, 389–422.
Rheinberger, H.-J. (1997). Toward a History of Epistemic Things: Synthesizing Proteins in the Test Tube. Palo Alto: Stanford University Press.
Richardson, S. (2011). Sexing the X: How the X Became the “Female Chromosome”. Signs, 37, 909–933.
Richardson, S. (2013). Sex Itself: The Search for Male and Female in the Human Genome. Chicago: University of Chicago Press.
Richmond, M. (1986). Richard Goldschmidt and sex determination: The growth of German genetics, 1900–1935. Unpublished Ph.D. Dissertation, Indiana University.
Richmond, M. (2007). The Cell as a Basis for Heredity, Development, and Evolution: Richard Goldschmidt’s Program of Physiological Genetics. In J. Maienschein & M. D. Laubichler (Eds.), From Embryology to Evo-Devo: A History of Evolutionary Development (pp. 169–210). Cambridge: MIT Press.
Ringer, F. (1969). The Decline of the German Mandarins: The German Academic Community, 1890–1933. Hanover: University Press of New England.
Satzinger, H. (2009). Racial Purity, Stable Genes and Sex Difference: Gender in the Making of Genetic Concepts by Richard Goldschmidt and Fritz Lenz, 1916–1936. In Susanne Heim, Carola Sachse, & Mark Walker (Eds.), The Kaiser Wilhelm Society under National Socialism (pp. 145–170). Cambridge: Cambridge University Press.
Schmidt, J. (1920). Racial Investigations IV – The genetic behavior of a secondary sexual character. Compt. Rend. Trav. Lab. Carlsberg Ser. Physiol., 14, 1–12.
Sengoopta, C. (1992). Science, Sexuality, and Gender in the Fin de Siecle: Otto Weininger as Baedeker. History of Science, 30, 249–279.
Steinach, E. (1916). Pubertätsdrüsen und Zwitterbildung. Archiv für Entwicklungsdynamik, 42, 307–332.
Stern, C. (1967). Richard Benedict Goldschmidt (1878-1958): A Biographical Memoir. In Richard Goldschmidt: Controversial Geneticist and Creative Biologist. Leonie Piternick (Ed.). Experientia Supplementum 35 (1980): 68–99.
Sturtevant, A. (1965). A history of genetics. New York: Harper and Row.
Syzbalski, W. (2001). My road to Øjvind Winge, the Father of Yeast Genetics. Genetics, 158, 1–6.
Toyama, K. (1916). Ichinino Mendel seisitu ni tsuite (On some Mendelian characters). Nippon Ikusyugakkai Hokoku, 1, 1–9.
Warmke, H. E., & Blakeslee, A. H. (1939). Sex mechanisms in polyploids of Melandrium. Science, 89, 391–392.
Westergaard, M. (1964). Øjvind Winge, 1886–1964. Biographical Memoirs of Fellows of the Royal Society, 10, 356–369.
Winge, Ø. (1927). The location of eighteen genes in Lebistes reticulatus. Journal of Genetics, 18, 1–42.
Winge, Ø. (1930). On the occurrence of XX males in Lebistes, with some remarks on Aida’s so-called ‘nondisjunctional’ males in Aplocheilus. Journal of Genetics, 23, 69–76.
Winge, Ø. (1932). The Nature of Sex Chromosomes. Proceedings of the Sixth International Congress of Genetics. Genetics Society of America
Winge, Ø. (1934). The experimental alteration of sex chromosomes into autosomes and vice versa, as illustrated by Lebistes. C.R Trav Lab Carlsberg, 21, 1–49.
Winge, Ø. (1937). Goldschmidt’s theory of sex determination in Lymantria. Journal of Genetics, 34, 81–87.
Winge, Ø., & Divtlevsen, E. (1938). A lethal gene in the Y chromosome of Lebistes. C. R. trav. Labor. Carlsberg, 27, 203–211.
Winge, Ø., & Divtlevsen, E. (1947). Colour inheritance and sex determination in Lebistes. Heredity, 1, 65–83.
This paper was originally developed for the Dartmouth Humanities Institute on Global Sexual Science. I am grateful for the comments of the Institute’s participants on my first draft of this essay and especially those of Rainer Herrn and Rebecca Hodes. I also benefitted from comments provided by Sarah Richardson and the anonymous referees for this journal.
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Dietrich, M.R. Experimenting with sex: four approaches to the genetics of sex reversal before 1950. HPLS 38, 23–41 (2016). https://doi.org/10.1007/s40656-015-0092-8
- Sex reversal
- Sex determination
- Experimental systems