Allergo Journal International

, Volume 27, Issue 3, pp 97–105 | Cite as

Sesame allergies: clinical significance, diagnosis, and therapy




Sesame (Sesameum indicum) belongs to the pedalium family (Pedaliaceae) and is used primarily in the preparation of food, especially in oriental and Asian cuisine. As a so-called emerging allergen, it is becoming increasingly relevant in the everyday routine of physicians active in the field of allergology in the wake of the globalization of dietary habits and the general trend towards vegetarian and vegan lifestyles. Due to the increased occurrence of anaphylactic reactions to sesame, the European Union has included sesame in the list of food allergens requiring labeling. In addition to its use in private and industrial food preparation, sesame is also utilized in the cosmetics and pharmaceutical industries.

Materials and methods

This paper is an overview of selected scientific articles and is based on research in PubMed and specialist databases.


Immediate-type IgE-mediated reactions (type I according to Coombs and Gell), as well as delayed-type contact allergic reactions (type IV according to Coombs and Gell), to products containing sesame and sesame oil have been described. The clinical spectrum is broad and ranges from contact urticaria and dermatitis to fatal anaphylaxis. Important allergens in immediate-type allergy include albumins, vicilins, oleosins, and globulins; relevant contact allergens include sesamolin, sesamin, and sesamol. The diagnostic work-up for suspected sesame allergy includes skin tests, which should preferentially be carried out with native allergens due to their higher sensitivity and specificity, as well as determination of sesame-specific IgE antibodies. However, lipophilic oleosins in particular are underrepresented in analytical methods. Differentiated, component-based IgE diagnostic testing is desirable. Oral provocation is the gold standard, whereby it is important to ensure low and safe initial doses as well as adequate maximum doses.


Beside diagnostic measurements including skin tests, detection of IgE antibodies and oral provocation tests, the education of patients with sesame allergy is of particular importance. This serves, firstly, to prevent recurrence of allergen exposure and, secondly, should contain information on self-management in the case of repeated reactions. The value of oral tolerance induction and preventive measures such as early introduction as a dietary supplement remains to be clarified in the future.


Sesame Sesame seeds Sesame oil Oleosins Allergy Anaphylaxis Cross-reactivity 



Working Group on Anaphylaxis Training and Education (Arbeitsgemeinschaft Anaphylaxie—Training und Edukation)


Basophil activation test


Study on Adult Health in Germany (Studie zur Gesundheit Erwachsener in Deutschland)


Immunoglobulin E




Negative predictive value


Oral provocation test


Positive predictive value


Wheat-dependent exercise-induced anaphylaxis


Conflict of interest

S. Mühlenbein and W. Pfützner declare that they have no competing interests.


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Copyright information

© Springer Medizin Verlag GmbH, a part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Dermatology and Allergology Marburgc/o Allergy Center Hessen Gießen and Marburg University HospitalMarburgGermany

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