A century of “intrinsic asthma”

A view on the development of phenotyping in asthma in the last 100 years
  • Thomas Rothe



One hundred years ago Rackemann published the first description of Intrinsic Asthma. This was the beginning of a process of phenotyping the disease.

Materials and methods

The literature regarding asthma phenotypes of the last 100 years has been checked. Lately, there have been many new publications dealing with this specific asthma phenotype.


Today, the term asthma is looked at as an umbrella covering different phenotypes of the disease. According to a recent publication, Intrinsic Asthma is most often cited now as eosinophilic adult-onset asthma. New treatment strategies for this phenotypes have evolved in recent years.


Asthma Allergy Intrinsic asthma Eosinophilic asthma Asthma phenotypes 


Conflict of interest

T. Rothe gave advice and has given lectures for: AstraZeneca, GSK, TEVA, and Novartis Pharma Schweiz.


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Copyright information

© Springer Medizin Verlag GmbH, a part of Springer Nature 2018

Authors and Affiliations

  1. 1.PneumologieKantonsspital GraubündenChurSwitzerland

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