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Successful pregnancy after 10 consecutive failures in a liver transplant patient with advanced kidney failure

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Abstract

We report a successful, albeit complicated pregnancy with a live-born healthy baby at 28 weeks' gestation, after 10 pregnancy failures, in a 39-year-old patient with a history of liver transplantation and chronic kidney disease with hypertension and proteinuria. Multidisciplinary management (obstetrician, nephrologist and hepatology transplant specialist) allowed close monitoring, adaptation of immunosuppressive treatments and strict control of fetal growth. The onset of preeclampsia at 28 weeks' gestation led to a cesarean section, resulting in the birth of a healthy 830 g boy, with subsequent normal development. Following pregnancy, the patient experienced liver transplant rejection, which resolved after adapting immunosuppressive drugs. No deterioration in kidney function was observed in the year following delivery.

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Data are available upon request from the corresponding author.

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Acknowledgements

The authors wish to thank Teresa Sawyers, medical writer at the BESPIM, Nîmes University Hospital, France, for her expertise in reviewing and editing.

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Authors and Affiliations

  1. Nephrology Dialysis Apheresis Department, Nîmes University Hospital Carémeau, Nîmes, France

    Leonard Cauchy & Olivier Moranne

  2. Gynecology Obstetrics Department, Nîmes University Hospital Carémeau, Nîmes, France

    Eve Mousty

  3. Hepatogastroenterology and Liver Transplantation Unit, Montpellier University Hospital Saint Eloi, Montpellier, France

    George-Philippe Pageaux

  4. IDESP, Montpellier, France

    Olivier Moranne

Authors
  1. Leonard Cauchy
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  2. Eve Mousty
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  3. George-Philippe Pageaux
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  4. Olivier Moranne
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Correspondence to Olivier Moranne.

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This study was performed in line with the principles of the Declaration of Helsinki.

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Cauchy, L., Mousty, E., Pageaux, GP. et al. Successful pregnancy after 10 consecutive failures in a liver transplant patient with advanced kidney failure. J Nephrol 37, 747–751 (2024). https://doi.org/10.1007/s40620-024-01936-5

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  • DOI: https://doi.org/10.1007/s40620-024-01936-5

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