Graphical abstract
![](http://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs40620-023-01619-7/MediaObjects/40620_2023_1619_Figa_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs40620-023-01619-7/MediaObjects/40620_2023_1619_Fig1_HTML.jpg)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs40620-023-01619-7/MediaObjects/40620_2023_1619_Fig2_HTML.jpg)
Data availability
The main author affirms that this manuscript is an honest, accurate and transparent account of the case being reported.
References
Larkins NG, Teixeira-Pinto A, Craig JC (2019) A narrative review of proteinuria and albuminuria as clinical biomarkers in children. J Paediatr Child Health 55(2):136–142. https://doi.org/10.1111/jpc.14293
Barut K, Sahin S, Adrovic A et al (2018) Familial Mediterranean fever in childhood: a single-center experience. Rheumatol Int 38:67–74. https://doi.org/10.1007/s00296-017-3796-0
Alghamdi M (2017) Familial Mediterranean fever, review of the literature. Clin Rheumatol 36:1707–1713. https://doi.org/10.1007/s10067-017-3715-5
Kukuy O, Livneh A, Ben-David A et al (2013) Familial Mediterranean fever (FMF) with proteinuria: clinical features, histology, predictors, and prognosis in a cohort of 25 patients. J Rheumatol 40(12):2083–2087. https://doi.org/10.3899/jrheum.130520
Liu D, Wen Y, Tang TT, Lv LL, Tang RN, Liu H, Ma KL, Crowley SD, Liu BC (2015) Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation. J Biol Chem 290(29):18018–18028. https://doi.org/10.1074/jbc.M115.662064
Gräsbeck R (2006) Imerslund-Gräsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria). Orphanet J Rare Dis 19(1):17. https://doi.org/10.1186/1750-1172-1-17
Storm T, Zeitz C, Cases O et al (2013) Detailed investigations of proximal tubular function in Imerslund-Gräsbeck syndrome. BMC Med Genet 24(14):111. https://doi.org/10.1186/1471-2350-14-111
Wahlstedt-Fröberg V, Pettersson T, Aminoff M, Dugué B, Gräsbeck R (2003) Proteinuria in cubilin-deficient patients with selective vitamin B12 malabsorption. Pediatr Nephrol 18(5):417–421. https://doi.org/10.1007/s00467-003-1128-y
Bedin M et al (2020) Human C-terminal CUBN variants associate with chronic proteinuria and normal renal function. J Clin Invest 130(1):335–344. https://doi.org/10.1172/JCI12937
Acknowledgements
We express our gratitude to PhD MD. F. Camassei for providing research material.
Funding
We declare no funding for this manuscript.
Author information
Authors and Affiliations
Contributions
NVE analyzed and compiled patient data with help from NK. PK contributed the figures and the anatomopathological consult. NVE wrote the manuscript with help from LDeS and NK. NK supervised the project.
Corresponding author
Ethics declarations
Conflict of interest
We declare no conflicts of interest.
Ethical approval
Ethical approval was not sought for this study because it was done with the consent of the patient and the data analyzed do not allow any identifcation.
Informed consent
Verbal consent was given by the mother.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Vanden Eynde, N., Koshy, P., De Somer, L. et al. Lessons for the clinical nephrologist: an unusual cause of isolated proteinuria in a child with Familial Mediterranean Fever. J Nephrol 36, 1699–1702 (2023). https://doi.org/10.1007/s40620-023-01619-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40620-023-01619-7