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Mitochondrial quality control in acute kidney disease

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Abstract

Acute kidney disease (AKD) involves multiple pathogenic mechanisms,  including maladaptive repair of renal cells that are rich in mitochondria. Maintenance of mitochondrial homeostasis and quality control is crucial for normal kidney function. Mitochondrial quality control serves to maintain mitochondrial function under various conditions, including mitochondrial bioenergetics, mitochondrial biogenesis, mitochondrial dynamics (fusion and fission) and mitophagy. To date, increasing evidence indicates that mitochondrial quality control is disrupted when acute kidney disease develops. This review describes the mechanisms of mitochondria quality control in acute kidney disease, aiming to provide clues to help design new clinical treatments.

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Funding

This work was supported by the National Natural Science Foundation of China (grant. no. 82100719); the Natural Science Foundation of Jiangsu Province (Grant. no. BK20210982).

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  1. Jingyi Sheng and Xian Li have contributed equally to this work.

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  1. Department of Pediatric Nephrology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China

    Jingyi Sheng, Juan Lei, WeiHua Gan & Jiayu Song

  2. Department of Emergency, Children’s Hospital of Nanjing Medical University, Nanjing, China

    Xian Li

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  1. Jingyi Sheng
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Sheng, J., Li, X., Lei, J. et al. Mitochondrial quality control in acute kidney disease. J Nephrol 36, 1283–1291 (2023). https://doi.org/10.1007/s40620-023-01582-3

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