![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs40620-022-01367-0/MediaObjects/40620_2022_1367_Fig1_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs40620-022-01367-0/MediaObjects/40620_2022_1367_Fig2_HTML.jpg)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs40620-022-01367-0/MediaObjects/40620_2022_1367_Fig3_HTML.jpg)
References
Dimopoulos MA, Terpos E, Chanan-Khan A, Leung N, Ludwig H, Jagannath S, Niesvizky R, Giralt S, Fermand JP, Blade J, Comenzo RL, Sezer O, Palumbo A, Harousseau JL, Richardson PG, Barlogie B, Anderson KC, Sonneveld P, Tosi P, Cavo M, Rajkumar SV, Durie BG, San Miguel J (2010) Renal impairment in patients with multiple myeloma: a consensus statement on behalf of the International Myeloma Working Group. J Clin Oncol 28(33):4976–4984
Haynes RJ, Read S, Collins GP, Darby SC, Winearls CG (2010) Presentation and survival of patients with severe acute kidney injury and multiple myeloma: A 20-year experience from a single centre. Nephrol Dial Transplant 25:419–426
Fricker LD (2020) Proteosome inhibitor drugs. Annu Rev Pharmacol Toxicol 60:457–476. https://doi.org/10.1146/annurev-pharmtox-010919-023603 (Epub 2019 Sep 3)
Siegel, D.S., Martin, T., Wang, M., Vij, R., Jakubowiak, A.J., Lonial, S., Trudel, S., Kukreti, V., Bahlis, N., Alsina, M., Chanan-Khan, A., Buadi, F., Reu, F.J., Somlo, G., Zonder, J., Song, K., Stewart, A.K., Stadtmauer, E., Kunkel, L., Wear, S., Wong, A.F., Orlowski, R.Z., Jagannath, S. (2012). A phase 2 study of single-agent carfilzomib (PX-171–003-A1) in patients with relapsed and refractory multiple myeloma. Blood. 120(14), 2817–25. Doi: https://doi.org/10.1182/blood-2012-05-425934. Epub 2012 Jul 25. PMID: 22833546; PMCID: PMC4123387.
Hájek, R., Masszi, T., Petrucci, M.T., Palumbo, A., Rosiñol, L., Nagler, A., Yong, K.L., Oriol, A., Minarik, J., Pour, L., Dimopoulos, M.A., Maisnar, V., Rossi, D., Kasparu, H., Van Droogenbroeck, J., Yehuda, D.B., Hardan, I., Jenner, M., Calbecka, M., Dávid, M., de la Rubia, J., Drach, J., Gasztonyi, Z., Górnik, S., Leleu, X., Munder, M., Offidani, M., Zojer, N., Rajangam, K., Chang, Y.L., San-Miguel, J.F., Ludwig, H. (2017). A randomized phase III study of carfilzomib vs low-dose corticosteroids with optional cyclophosphamide in relapsed and refractory multiple myeloma (FOCUS). Leukemia. 31(1), 107–114. Doi: https://doi.org/10.1038/leu.2016.176. Epub 2016 Jun 24. PMID: 27416912; PMCID: PMC5220126.
Yui JC, Van Keer J, Weiss BM, Waxman AJ, Palmer MB, D’Agati VD, Kastritis E, Dimopoulos MA, Vij R, Bansal D, Dingli D, Nasr SH, Leung N (2016) Proteasome inhibitor associated thrombotic microangiopathy. Am J Hematol 91(9):E348–E352. https://doi.org/10.1002/ajh.24447 (Epub 2016 Jul 4 PMID: 27286661)
Ball S, Behera TR, Anwer F, Chakraborty R (2020) Risk of kidney toxicity with carfilzomib in multiple myeloma: a meta-analysis of randomized controlled trials. Ann Hematol 99(6):1265–1271. https://doi.org/10.1007/s00277-020-04062-x (Epub 2020 May 7 PMID: 32382772)
Liberman V, D’Agati VD, Masani NN, Drakakis J, Mattana J (2016) Acute Tubular Necrosis in a Patient With Myeloma Treated With Carfilzomib. Kidney Int Rep 1(2):89–92. https://doi.org/10.1016/j.ekir.2016.06.002.PMID:29142917;PMCID:PMC5678606
Fotiou D, Roussou M, Gakiopoulou C, Psimenou E, Gavriatopoulou M, Migkou M, Kanellias N, Dialoupi I, Eleutherakis-Papaiakovou E, Giannouli S, Delavinia C, Efstathiou K, Kontogiannis S, Terpos E, Dimopoulos MA, Kastritis E (2020) Carfilzomib-associated renal toxicity is common and unpredictable: a comprehensive analysis of 114 multiple myeloma patients. Blood Cancer J 10(11):109. https://doi.org/10.1038/s41408-020-00381-4.PMID:33149167;PMCID:PMC7642386
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
All authors declare that they have no conflicts of interest.
Ethical statement
The informed consent was obtained from the patient for anonymous use of renal biopsy images and data.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Giannese, D., Bonadio, A.G., Del Giudice, M.L. et al. Carfilzomib-related glomerular and tubular injury in a patient with Multiple Myeloma. J Nephrol 35, 2131–2134 (2022). https://doi.org/10.1007/s40620-022-01367-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40620-022-01367-0