Skip to main content

Advertisement

SpringerLink
Log in

Atypical hemolytic uremic syndrome complicating relapsing cryoglobulinemic membranoproliferative glomerulonephritis despite hepatitis C eradication

  • Lessons for the Clinical Nephrologist
  • Published:
Journal of Nephrology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Noris M, Galbusera M, Gastoldi S et al (2014) Dynamics of complement activation in aHUS and how to monitor eculizumab therapy. Blood 124(11):1715–1726

    Article  CAS  Google Scholar 

  2. Abarrategui-Garrido C, Martínez-Barricarte R, López-Trascasa M, de Córdoba SR, Sánchez-Corral P (2009) Characterization of complement factor H-related (CFHR) proteins in plasma reveals novel genetic variations of CFHR1 associated with atypical hemolytic uremic syndrome. Blood 114(19):4261–4271

    Article  CAS  Google Scholar 

  3. Obrișcă B, Jurubiță R, Sorohan B et al (2019) Clinical outcome of HCV-associated cryoglobulinemic glomerulonephritis following treatment with direct acting antiviral agents: a case-based review. Clin Rheumatol 38(12):3677–3687

    Article  Google Scholar 

  4. Saadoun D, Pol S, Ferfar Y et al (2017) Efficacy and safety of sofosbuvir plus daclatasvir for treatment of HCV-associated cryoglobulinemia vasculitis. Gastroenterology 153(1):49–52

    Article  CAS  Google Scholar 

  5. Bonacci M, Lens S, Mariño Z et al (2018) Long-term outcomes of patients with HCV-associated cryoglobulinemic vasculitis after virologic cure. Gastroenterology 155(2):311-315.e6

    Article  Google Scholar 

  6. Visentini M, Del Padre M, Colantuono S et al (2019) Long-lasting persistence of large B-cell clones in hepatitis C virus-cured patients with complete response of mixed cryoglobulinaemia vasculitis. Liver Int 39(4):628–632

    Article  CAS  Google Scholar 

  7. Bunchorntavakul C, Mitrani R, Reddy KR (2018) Advances in HCV and cryoglobulinemic vasculitis in the era of DAAs: are we at the end of the road? J Clin Exp Hepatol 8(1):81–94

    Article  Google Scholar 

  8. Fabrizi F, Cerutti R, Porata G, Messa P, Ridruejo E (2019) Direct-acting antiviral agents for HCV-associated glomerular disease and the current evidence. Pathogens 8(4):176

    Article  CAS  Google Scholar 

  9. Wu H, Zou HB, Xu Y et al (2013) Hepatitis C virus-related heat-insoluble cryoglobulinemia and thrombotic microangiopathy. Am J Med Sci 346(4):345–348

    Article  Google Scholar 

Download references

Funding

None.

Author information

Authors and Affiliations

  1. Dipartimento di Medicina Generale e Specialistica, U.O. Nefrologia, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci, 14, 43126, Parma, Italy

    Micaela Gentile MD, Giovanni Maria Rossi, Marco Delsante, Cristina Zambrano, Alessio Di Maria, Enrico Fiaccadori & Lucio Manenti

  2. Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy

    Micaela Gentile MD, Giovanni Maria Rossi, Marco Delsante, Cristina Zambrano, Alessio Di Maria, Enrico Fiaccadori & Lucio Manenti

Authors
  1. Micaela Gentile MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Giovanni Maria Rossi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marco Delsante
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Cristina Zambrano
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alessio Di Maria
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Enrico Fiaccadori
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Lucio Manenti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Giovanni Maria Rossi.

Ethics declarations

Conflict of Interest

None declared.

Ethical statement

The authors declare that they have obtained consent from the patient reported in this article for publication of the information about him/her that appears within this Case Report and any associated supplementary material.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic Supplementary Material

Below is the link to the electronic supplementary material.

40620_2021_998_MOESM1_ESM.xlsx

Table S1.Laboratory tests starting from the most recent hospitalization. Hb: hemoglobin; PLT: platelets; LDH; lactate dehydrogenase; sCr: serum creatinine; UPCR: urinary protein-to-creatinine ratio.

40620_2021_998_MOESM2_ESM.eps

Figure S1.Time-dependent values of serum C3 concentration, platelet count and blood hemoglobin concentration starting from hospitalization up to 8 months follow-up. Time course of the concentration of selected analytes (serum C3 [sC3], platelets [PLT], hemoglobin [Hb]). RTX: rituximab. Day 0 = day of admission. The patient was admitted on November 8, 2018 and discharged on February 4, 2019 (overall 89 days of hospitalization).

Supplementary Material (DOCX 14 KB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gentile, M., Rossi, G.M., Delsante, M. et al. Atypical hemolytic uremic syndrome complicating relapsing cryoglobulinemic membranoproliferative glomerulonephritis despite hepatitis C eradication. J Nephrol 35, 327–330 (2022). https://doi.org/10.1007/s40620-021-00998-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40620-021-00998-z

Search

Navigation