Nephrology consultation and kidney failure in people with stage 4 chronic kidney disease: a population-based cohort study

Abstract

Background

Guidelines recommend referral for nephrology consultation for people with severe chronic kidney disease (CKD) to improve care and renal outcomes, yet the advocated benefits of nephrology referral on CKD progression in this patient population are unclear.

Methods

We linked laboratory and administrative data in Alberta, Canada to identify adults with stage 4 CKD between 2002 and 2014 (follow-up end on March 31, 2017). We studied the association between time-varying receipt of outpatient nephrology consultation and kidney failure (the earlier of renal replacement initiation or eGFR < 10 mL/min/1.73 m2 for more than 3 months), accounting for the competing risk of death.

Results

Of the 14,382 participants, 41% were ≥ 85 years old, 33% saw a nephrologist as an outpatient, 9% developed kidney failure, and 53% died over a median of 2.6 years. Compared with people who did not see a nephrologist before or at 7 months (median time to consultation), those who did were more likely to develop kidney failure [5-year risk (95% CI) 0.23 (0.21–0.24) vs 0.07 (0.065–0.075)]. With increasing age or higher eGFR, the 5-year risk of kidney failure became progressively smaller, from 0.24 (0.18–0.29) at age < 65 to 0.01 (0.006–0.015) at age ≥ 85 years and from 0.21 (0.18–0.23) at eGFR 15–19 to 0.066 (0.060–0.072) at eGFR 25–29 mL/min/1.73 m2; yet, the hazard ratio of kidney failure (1.6–4.3) increased following nephrology consultation in people who were older or had higher eGFR.

Conclusions

Adults with stage 4 CKD who see a nephrologist are more likely to develop kidney failure than those who don’t, especially within lower absolute risk categories. Although selective referral may explain these findings, there is no evidence of an association between nephrology care and reduced risk of kidney failure in people with severe CKD. Studies are needed to assess the benefits of nephrology consultation in people with moderate CKD.

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Availability of data and material

The datasets generated during and/or analysed during the current study are not publicly available due to ethical/legal restrictions.

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Funding

Ping Liu was supported by post-doctoral fellowships from the Canadian Institutes of Health Research (Funding Reference Number MFE-152465), the Cumming School of Medicine of the University of Calgary, and the Libin Cardiovascular Institute of Alberta. The funding organizations had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.

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Authors

Contributions

PL, RQ and PR designed the work. PL and PR analyzed the data. GC supervised the analysis plan. PL and PR drafted the manuscript. All authors revised it critically for important intellectual content and approved the final version of the manuscript.

Corresponding author

Correspondence to Pietro Ravani.

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Conflict of interest

The authors declare that they have no competing interest.

Ethics approval, consent to participate, and consent for publication

This study was approved by the Conjoint Health Research Ethics Board of the University of Calgary (REB16-1575), with a waiver of patient consent for participation and publication.

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Available upon reasonable request.

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Disclaimer

This study is based in part by data provided by Alberta Health and Alberta Health Services. The interpretation and conclusions are those of the researchers and do not represent the views of the Government of Alberta. Neither the Government of Alberta nor Alberta Health express any opinion in relation to this study.

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Liu, P., Quinn, R.R., Cortese, G. et al. Nephrology consultation and kidney failure in people with stage 4 chronic kidney disease: a population-based cohort study. J Nephrol (2020). https://doi.org/10.1007/s40620-020-00892-0

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Keywords

  • Nephrology consultation
  • Referral
  • Kidney failure
  • Mortality
  • Competing risks