Women and acute kidney injury in myocardial infarction
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Data on the relationship between gender and acute kidney injury (AKI) in patients with myocardial infarction (MI) undergoing percutaneous coronary intervention (PCI) are conflicting and inconclusive. The contrast volume-to-estimated glomerular filtration rate ratio (CV/GFR) was shown to predict AKI in patients with MI undergoing PCI. We assessed gender-based differences in AKI and evaluated the association between the CV/GFR and AKI in MI patients undergoing PCI.
We retrospectively studied 4675 consecutive patients with MI who underwent PCI between January 2007 and December 2015. The incidence of AKI and CV/GFR in men and women were compared. Data were analyzed using descriptive statistics.
Women suffered more AKI than men [152 (10.5%) women suffered AKI compared to 252 (7.8%) men; p = 0.003]. After adjustment for potential confounders, female gender was identified as an independent predictive factor for AKI. CV/GFR was higher in women (2.57 ± 1.95 in women vs. 2.25 ± 1.60 in men; p < 0.0001) and predicted AKI.
AKI occurs more often in women than men with MI undergoing PCI. Female gender independently predicted AKI in our analysis. A high CV/GFR denotes a group of patients who are at higher risk of AKI after PCI. CV/GFR was significantly higher in women, which may help to explain their worse outcome as regards AKI.
KeywordsAcute kidney injury Myocardial infarction Women Percutaneous coronary intervention
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Compliance with ethical standards
Conflict of interest
There was no conflict of interest on the part of any author.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
- 4.Marenzi G, Cosentino N, Moltrasio M, Rubino M, Crimi G, Buratti S et al (2016) Acute kidney injury definition and in-hospital mortality in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. J Am Heart Assoc 5:e003522CrossRefPubMedPubMedCentralGoogle Scholar
- 9.Watabe H, Sato A, Hoshi T, Takeyasu N, Abe D, Akiyama D et al (2014) Association of contrast-induced acute kidney injury with long-term cardiovascular events in acute coronary syndrome patients with chronic kidney disease undergoing emergent percutaneous coronary intervention. Int J Cardiol 174:57–63CrossRefPubMedGoogle Scholar
- 14.Mager A, Vaknin Assa H, Lev EI, Bental T, Assali A, Kornowski R (2011) The ratio of contrast volume to glomerular filtration rate predicts outcomes after percutaneous coronary intervention for ST-segment elevation acute myocardial infarction. Catheter Cardiovasc Interv 78:198–201CrossRefPubMedGoogle Scholar
- 15.Shacham Y, Leshem-Rubinow E, Steinvil A, Assa EB, Keren G, Roth A et al (2014) Renal impairment according to acute kidney injury network criteria among ST elevation myocardial infarction patients undergoing primary percutaneous intervention: a retrospective observational study. Clin Res Cardiol 103:525–532CrossRefPubMedGoogle Scholar
- 19.Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H et al (2017) 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 00:1–66Google Scholar
- 24.Nutritional Anaemias (1968) Report of a WHO scientific group. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity VMNIS. World Health Organization, GenevaGoogle Scholar
- 31.Laskey WK, Jenkins C, Selzer F, Marroquin OC, Wilensky RL, Glaser R et al (2007) Volume-to-creatinine clearance ratio: a pharmacokinetically based risk factor for prediction of early creatinine increase after percutaneous coronary intervention. J Am Coll Cardiol 50:584–590CrossRefPubMedGoogle Scholar