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Women and acute kidney injury in myocardial infarction

  • Original Article
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Journal of Nephrology Aims and scope Submit manuscript

Abstract

Background

Data on the relationship between gender and acute kidney injury (AKI) in patients with myocardial infarction (MI) undergoing percutaneous coronary intervention (PCI) are conflicting and inconclusive. The contrast volume-to-estimated glomerular filtration rate ratio (CV/GFR) was shown to predict AKI in patients with MI undergoing PCI. We assessed gender-based differences in AKI and evaluated the association between the CV/GFR and AKI in MI patients undergoing PCI.

Methods

We retrospectively studied 4675 consecutive patients with MI who underwent PCI between January 2007 and December 2015. The incidence of AKI and CV/GFR in men and women were compared. Data were analyzed using descriptive statistics.

Results

Women suffered more AKI than men [152 (10.5%) women suffered AKI compared to 252 (7.8%) men; p = 0.003]. After adjustment for potential confounders, female gender was identified as an independent predictive factor for AKI. CV/GFR was higher in women (2.57 ± 1.95 in women vs. 2.25 ± 1.60 in men; p < 0.0001) and predicted AKI.

Conclusion

AKI occurs more often in women than men with MI undergoing PCI. Female gender independently predicted AKI in our analysis. A high CV/GFR denotes a group of patients who are at higher risk of AKI after PCI. CV/GFR was significantly higher in women, which may help to explain their worse outcome as regards AKI.

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Division of Internal Medicine, Department of Cardiology and Angiology, University Medical Center Maribor, Ljubljanska Ulica 5, 2000, Maribor, Slovenia

    Vojko Kanic, Gregor Kompara, David Suran & Radovan Hojs

  2. Herzzentrum Leipzig, Strümpellstraße 39, Leipzig, Germany

    Maja Vollrath

  3. Faculty of Medicine, University of Maribor, Maribor, Slovenia

    Radovan Hojs

Authors
  1. Vojko Kanic
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  2. Maja Vollrath
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  3. Gregor Kompara
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  4. David Suran
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Correspondence to Vojko Kanic.

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There was no conflict of interest on the part of any author.

Ethical disclosures

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Kanic, V., Vollrath, M., Kompara, G. et al. Women and acute kidney injury in myocardial infarction. J Nephrol 31, 713–719 (2018). https://doi.org/10.1007/s40620-018-0504-4

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  • DOI: https://doi.org/10.1007/s40620-018-0504-4

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