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IgA nephropathy and infections

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Abstract

In this paper we concentrate on the role of infections in IgA nephropathy both from a pathogenetic and clinic point of view. The current hypotheses as regards the role of infections in the pathogenesis of IgA nephropathy are: (a) role of particular pathogens, (b) chronic exposure to mucosal infections, (c) abnormal handling of commensal microbes (gut microbiota). We also focus on particular infections reported in association with classic IgA nephropathy (HIV, malaria, Chlamydia, Lyme disease), as well as on IgA dominant-infection-associated glomerulonephritis. This is a unique form of glomerulonephritis, where IgA deposition is dominant. It is mostly recognized in old, diabetic patients and in association with staphylococcal infection.

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Authors and Affiliations

  1. SCDU Nefrologia e Dialisi, Ospedale S. G. Bosco, P.za Donatore di Sangue 3, 10154, Turin, Italy

    Cristiana Rollino

  2. Divisione di Nefrologia, Fondazione Policlinico Gemelli, Università Cattolica, Rome, Italy

    Gisella Vischini

  3. Fondazione Ricerca Molinette, Ospedale Regina Margherita, Turin, Italy

    Rosanna Coppo

Authors
  1. Cristiana Rollino
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  2. Gisella Vischini
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  3. Rosanna Coppo
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Correspondence to Cristiana Rollino.

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The authors declare that there is no conflict of interest.

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The paper is a review, hence it does not involve human participants and/or animals and no informed consent is required.

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Rollino, C., Vischini, G. & Coppo, R. IgA nephropathy and infections. J Nephrol 29, 463–468 (2016). https://doi.org/10.1007/s40620-016-0265-x

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  • DOI: https://doi.org/10.1007/s40620-016-0265-x

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