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Childhood cancer survivors, infiammazione e invecchiamento precoce

Premature ageing and inflammation in survivors of childhood cancer

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L'Endocrinologo Aims and scope

Sommario

Grazie al progresso delle terapie oncologiche, il numero di giovani adulti guariti da tumori dell’età pediatrica (i cosiddetti childhood cancer survivors) è in costante aumento. Numerose evidenze dimostrano che questi soggetti possono andare incontro all’insorgenza precoce di patologie, soprattutto cardiovascolari e oncologiche, tipiche dell’età avanzata, facendo ipotizzare che le terapie anti-tumorali possano determinare un’accelerazione dei fisiologici meccanismi di invecchiamento. Questa rassegna riassume le principali evidenze sul ruolo dell’infiammazione cronica all’interno dei meccanismi di ageing prematuro che caratterizzano i childhood cancer survivors.

Abstract

Thanks to the improvements in cancer treatment protocols, the number of childhood cancer survivors within the general population is constantly increasing. Several studies showed that these patients can prematurely experience health conditions (e.g., cardiovascular diseases, cancer) that usually affect older people. Therefore, it has been hypothesised that anticancer therapies can accelerate the development of physiological mechanism of senescence. This review summarises the recent evidence about the role of chronic low grade inflammation in the onset of premature ageing in survivors of childhood cancer.

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Authors and Affiliations

  1. S.C. Endocrinologia Oncologica U, A.O.U. Città della Salute e della Scienza di Torino e Università di Torino, Torino, Italia

    Francesco Felicetti, Nicoletta Fortunati, Filippo Gatti & Emanuela Arvat

  2. Sezione Patologia Generale, Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Torino, Italia

    Eleonora Aimaretti & Manuela Aragno

  3. S.C. Oncoematologia Pediatrica U, A.O.U. Città della Salute e della Scienza di Torino e Università di Torino, Torino, Italia

    Eleonora Biasin & Franca Fagioli

Authors
  1. Francesco Felicetti
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  2. Eleonora Aimaretti
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  3. Nicoletta Fortunati
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  4. Filippo Gatti
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  5. Eleonora Biasin
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  6. Franca Fagioli
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  7. Manuela Aragno
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  8. Emanuela Arvat
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Corresponding author

Correspondence to Francesco Felicetti.

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Conflitto di interesse

Gli autori Francesco Felicetti, Eleonora Aimaretti, Nicoletta Fortunati, Filippo Gatti, Eleonora Biasin, Franca Fagioli, Manuela Aragno e Emanuela Arvat dichiarano di non avere conflitti di interesse.

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Lo studio presentato in questo articolo non ha richiesto sperimentazione umana.

Studi sugli animali

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Proposto da E. Arvat.

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Felicetti, F., Aimaretti, E., Fortunati, N. et al. Childhood cancer survivors, infiammazione e invecchiamento precoce. L'Endocrinologo 25, 196–202 (2024). https://doi.org/10.1007/s40619-024-01438-3

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