Skip to main content
SpringerLink
Log in

Terapia con GH in bambini nati piccoli per l’età gestazionale: indicazioni, efficacia e sicurezza

  • RASSEGNA
  • Published:
L'Endocrinologo Aims and scope

Sommario

I bambini nati piccoli per l’età gestazionale (small for gestational age, SGA) nella maggior parte dei casi presentano un recupero staturo-ponderale (catch-up growth) entro i primi due anni di vita. Il 10% circa non presenta catch-up growth, con conseguente bassa statura. La terapia con GH si è rivelata efficace per il raggiungimento dell’altezza target e presenta un profilo di sicurezza favorevole.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Bibliografia

  1. Clayton PE, Cianfarani S, Czernichow P et al. (2007) Management of the child born small for gestational age through to adulthood: a consensus statement of the international societies of pediatric endocrinology and the growth hormone research society. J Clin Endocrinol Metab 92(3):804–810

    Article  CAS  Google Scholar 

  2. Jung H, Rosilio M, Blum WF, Drop SL (2008) Growth hormone treatment for short stature in children born small for gestational age. Adv Ther 25(10):951–978

    Article  CAS  Google Scholar 

  3. Ruiz M, Goldblatt P, Morrison J et al. (2015) Mother’s education and the risk of preterm and small for gestational age birth: a DRIVERS meta-analysis of 12 European cohorts. J Epidemiol Community Health 69(9):826–833

    Article  Google Scholar 

  4. Bryan SM, Hindmarsh PC (2006) Normal and abnormal fetal growth. Horm Res 65(Suppl 3):19–27

    CAS  PubMed  Google Scholar 

  5. Finken MJ, van der Steen M, Smeets CC et al. (2018) Children born small for gestational age: differential diagnosis, molecular genetic evaluation, and implications. Endocr Rev 39(6):851–894

    Article  Google Scholar 

  6. Karlberg JP, Albertsson-Wikland K, Kwan EY et al. (1997) The timing of early postnatal catch-up growth in normal, full-term infants born short for gestational age. Horm Res 48(Suppl 1):17–24.

    Article  CAS  Google Scholar 

  7. Luo ZC, Albertsson-Wikland K, Karlberg J (1998) Length and body mass index at birth and target height influences on patterns of postnatal growth in children born small for gestational age. Pediatrics 102(6):E72

    Article  CAS  Google Scholar 

  8. Deodati A, Cianfarani S (2017) The rationale for growth hormone therapy in children with short stature. J Clin Res Pediatr Endocrinol 9(Suppl 2):23–32

    PubMed  PubMed Central  Google Scholar 

  9. Grunt JA, Howard CP, Daughaday WH (1984) Comparison of growth and somatomedin C responses following growth hormone treatment in children with small-for-date short stature, significant idiopathic short stature and hypopituitarism. Acta Endocrinol (Copenh) 106(2):168–174

    Article  CAS  Google Scholar 

  10. Boguszewski M, Rosberg S, Albertsson-Wikland K (1995) Spontaneous 24-hour growth hormone profiles in prepubertal small for gestational age children. J Clin Endocrinol Metab 80(9):2599–2606

    CAS  PubMed  Google Scholar 

  11. Argente J, Gracia R, Ibáñez L et al. (for the Spanish SGA Working Group) (2007) Improvement in growth after two years of growth hormone therapy in very young children born small for gestational age and without spontaneous catch-up growth: results of a multicenter, controlled, randomized, open clinical trial. J Clin Endocrinol Metab 92(8):3095–3101

    Article  CAS  Google Scholar 

  12. Sas T, de Waal W, Mulder P et al. (1999) Growth hormone treatment in children with short stature born small for gestational age: 5-year results of a randomized, double-blind, dose-response trial. J Clin Endocrinol Metab 84(9):3064–3070

    CAS  PubMed  Google Scholar 

  13. Maiorana A, Cianfarani S (2009) Impact of growth hormone therapy on adult height of children born small for gestational age. Pediatrics 124(3):e519–531

    Article  Google Scholar 

  14. Lem AJ, van der Kaay DC, de Ridder MA et al. (2012) Adult height in short children born SGA treated with growth hormone and gonadotropin releasing hormone analog: results of a randomized, dose-response GH trial. J Clin Endocrinol Metab 97(11):4096–4105

    Article  CAS  Google Scholar 

  15. Rokkas T, Pistiolas D, Sechopoulos P et al. (2008) Risk of colorectal neoplasm in patients with acromegaly: a meta-analysis. World J Gastroenterol 14(22):3484–3489 16

    Article  PubMed Central  Google Scholar 

  16. Renehan AG, Zwahlen M, Minder C et al. (2004) Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 363(9418):1346–1353

    Article  CAS  Google Scholar 

  17. Watanabe S, Mizuno S, Oshima LH et al. (1993) Leukemia and other malignancies among GH users. J Pediatr Endocrinol 6(1):99–108

    Article  CAS  Google Scholar 

  18. Bell J, Parker KL, Swinford RD et al. (2010) Long-term safety of recombinant human growth hormone in children. J Clin Endocrinol Metab 95(1):167–177

    Article  CAS  Google Scholar 

  19. Choi DK, Helenowski I, Hijiya N (2014) Secondary malignancies in pediatric cancer survivors: perspectives and review of the literature. Int J Cancer 135(8):1764–1773

    Article  CAS  Google Scholar 

  20. Swerdlow AJ, Cooke R, Albertsson-Wikland K et al. (2015) Description of the SAGhE cohort: a large European study of mortality and cancer incidence risks after childhood treatment with recombinant growth hormone. Horm Res Paediatr 84(3):172–183

    Article  CAS  PubMed Central  Google Scholar 

  21. Sävendahl L, Maes M, Albertsson-Wikland K et al. (2012) Long-term mortality and causes of death in isolated GHD, ISS, and SGA patients treated with recombinant growth hormone during childhood in Belgium, the Netherlands, and Sweden: preliminary report of 3 countries participating in the EU SAGhE study. J Clin Endocrinol Metab 97(2):E213–217

    Article  Google Scholar 

  22. Albertsson-Wikland K, Mårtensson A, Sävendahl L et al. (2016) Mortality is not increased in recombinant human growth hormone-treated patients when adjusting for birth characteristics. J Clin Endocrinol Metab 101(5):2149–2159

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Unità di Endocrinologia, A.O. San Camillo-Forlanini, Roma, Italia

    Francesca Rota, Roberto Baldelli & Paolo Zuppi

Authors
  1. Francesca Rota
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Roberto Baldelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Paolo Zuppi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Francesca Rota.

Ethics declarations

Conflitto di interesse

Gli autori Francesca Rota, Roberto Baldelli e Paolo Zuppi dichiarano di non avere conflitti di interesse.

Consenso informato

Lo studio presentato in questo articolo non ha richiesto sperimentazione umana.

Studi sugli animali

Gli autori di questo articolo non hanno eseguito studi sugli animali.

Additional information

Proposto da Roberto Baldelli.

Nota della casa editrice

Springer Nature rimane neutrale in riguardo alle rivendicazioni giurisdizionali nelle mappe pubblicate e nelle affiliazioni istituzionali.

Informazioni Supplementari

I link al materiale elettronico supplementare sono elencati qui sotto.

(DOC 40 kB)

(DOC 37 kB)

(DOC 41 kB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rota, F., Baldelli, R. & Zuppi, P. Terapia con GH in bambini nati piccoli per l’età gestazionale: indicazioni, efficacia e sicurezza. L'Endocrinologo 23, 252–257 (2022). https://doi.org/10.1007/s40619-022-01066-9

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40619-022-01066-9

Parole chiave

Search

Navigation