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Ruolo dell’esercizio fisico nel trattamento del carcinoma della mammella positivo al recettore degli estrogeni

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L'Endocrinologo Aims and scope

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Il cancro al seno è la neoplasia più comunemente diagnosticata tra le donne e la causa più comune di mortalità cancro-correlata nel sesso femminile. Esistono diversi tipi di tumore al seno classificati sulla base delle loro differenti caratteristiche molecolari; tuttavia, ad oggi quello più comunemente diagnosticato è il carcinoma estrogeno- e progestinico-sensibile. Dati scientifici hanno dimostrato il ruolo positivo dell’esercizio fisico nella riduzione significativa del rischio di insorgenza e nella gestione del trattamento del tumore, in quanto fattore coadiuvante le tradizionali terapie farmacologiche. In questa rassegna abbiamo focalizzato la nostra attenzione su dati clinici riguardanti l’impatto dell’esercizio fisico nei diversi livelli di prevenzione del tumore al seno positivo al recettore degli estrogeni.

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Bibliografia

  1. Harbeck N, Penault-Llorca F, Cortes J et al. (2019) Breast cancer. Nat Rev Dis Primers 5:66

    Article  Google Scholar 

  2. Cheang MC, Martin M, Nielsen TO et al. (2015) Defining breast cancer intrinsic subtypes by quantitative receptor expression. The Oncologist 20:474–482

    Article  CAS  Google Scholar 

  3. Dasso NA (2019) How is exercise different from physical activity? A concept analysis. Nurs Forum 54:45–52

    Article  Google Scholar 

  4. WHO (2020) WHO guidelines on physical activity and sedentary behavior. World Health Organization, Geneva

    Google Scholar 

  5. Kushi LH, Doyle C, McCullough M et al. (2012) American Cancer Society 2006 Nutrition and Physical Activity Guidelines Advisory Committee. American cancer society guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin 62:30–67

    Article  Google Scholar 

  6. World Cancer Research Fund/American Institute for Cancer Research (2018) Diet, nutrition, physical activity and cancer: a global perspective. Continuous update project external report. http://www.dietandcancerreport.org/. Accessed on 27 Dec 2021

  7. Friedenreich CM, Woolcott CG, McTiernan A et al. (2010) Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. J Clin Oncol 28:1458–1466

    Article  CAS  Google Scholar 

  8. Friedenreich CM, Wang Q, Yasui Y et al. (2019) Long-term effects of moderate versus high durations of aerobic exercise on biomarkers of breast cancer risk: follow-up to a randomized controlled trial. Cancer Epidemiol Biomark Prev 28:1725–1734

    Article  CAS  Google Scholar 

  9. Campbell KL, Foster-Schubert KE, Alfano CM et al. (2012) Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial. J Clin Oncol 30:2314–2326

    Article  CAS  Google Scholar 

  10. van Gemert WA, May AM, Schuit AJ et al. (2016) Effect of weight loss with or without exercise on inflammatory markers and adipokines in postmenopausal women: the shape-2 trial, a randomized controlled trial. Cancer Epidemiol Biomark Prev 25:799–806

    Article  Google Scholar 

  11. Khosravi N, Eskandari Z, Farajivafa V et al. (2018) Effect of 6 months of aerobic training on adipokines as breast cancer risk factors in postmenopausal women: a randomized controlled trial. J Cancer Res Ther 14:1336–1340

    CAS  PubMed  Google Scholar 

  12. Matthews CE, Sampson JN, Brenner DR et al. (2018) Effects of exercise and cardiorespiratory fitness on estrogen metabolism in postmenopausal women. Cancer Epidemiol Biomark Prev 27:1480–1482

    Article  Google Scholar 

  13. Duggan C, Tapsoba JD, Stanczyk F et al. (2019) Long-term weight loss maintenance, sex steroid hormones, and sex hormone-binding globulin. Menopause 26:417–422

    Article  Google Scholar 

  14. Gonzalo-Encabo P, Valadés D, García-Honduvilla N et al. (2020) Exercise type and fat mass loss regulate breast cancer-related sex hormones in obese and overweight postmenopausal women. Eur J Appl Physiol 120:1277

    Article  CAS  Google Scholar 

  15. Schwartz AL, Winters-Stone K (2009) Effects of a 12-month randomized controlled trial of aerobic or resistance exercise during and following cancer treatment in women. Phys Sportsmed 37:62–67

    Article  Google Scholar 

  16. Irwin ML, Alvarez-Reeves M, Cadmus L et al. (2009) Exercise improves body fat, lean mass, and bone mass in breast cancer survivors. Obesity (Silver Spring) 17:1534–1541

    Article  Google Scholar 

  17. Rogers LQ, Vicari S, Trammell R et al. (2014) Biobehavioral factors mediate exercise effects on fatigue in breast cancer survivors. Med Sci Sports Exerc 46:1077–1088

    Article  Google Scholar 

  18. Rogers LQ, Fogleman A, Trammell R et al. (2015) Inflammation and psychosocial factors mediate exercise effects on sleep quality in breast cancer survivors: pilot randomized controlled trial. Psychooncology 24:302–310

    Article  Google Scholar 

  19. Mijwel S, Backman M, Bolam KA (2015) Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial. Breast Cancer Res Treat 168:79–93

    Article  Google Scholar 

  20. Courneya KS, Segal RJ, McKenzie DC et al. (2014) Effects of exercise during adjuvant chemotherapy on breast cancer outcomes. Med Sci Sports Exerc 46:1744–1751

    Article  CAS  Google Scholar 

  21. Demark-Wahnefried W, George SL, Switzer BR et al. (2008) Overcoming challenges in designing and implementing a phase II randomized controlled trial using a presurgical model to test a dietary intervention in prostate cancer. Clin Trials 5:262–272

    Article  Google Scholar 

  22. Scott E, Daley AJ, Doll H et al. (2013) Effects of an exercise and hypocaloric healthy eating program on biomarkers associated with long-term prognosis after early-stage breast cancer: a randomized controlled trial. Cancer Causes Control 24:181–191

    Article  CAS  Google Scholar 

  23. Artene D, Blidaru A (2018) Factors that influence oncology nutrition efficacy in breast cancer patients under antiestrogenic treatment. Ann Oncol 29:603–640

    Article  Google Scholar 

  24. Scott JM, Iyengar NM, Nilsen TS et al. (2018) Feasibility, safety, and efficacy of aerobic training in pretreated patients with metastatic breast cancer: a randomized controlled trial. Cancer 124:2552–2560

    Article  CAS  Google Scholar 

  25. Yee J, Davis GM, Hackett D, Beith JM et al. (2019) Physical activity for symptom management in women with metastatic breast cancer: a randomized feasibility trial on physical activity and breast metastases. J Pain Symptom Manag 58:929–939

    Article  Google Scholar 

  26. Carson JW, Carson KM, Olsen M et al. (2020) Yoga practice predicts improvements in day-to-day pain in women with metastatic breast cancer. J Pain Symptom Manag 14:30804–30806

    Google Scholar 

  27. Coughlin SS (2019) Epidemiology of breast cancer in women. Adv Exp Med Biol 1152:9–29

    Article  CAS  Google Scholar 

  28. Walter KR, Ford ME, Gregoski MJ et al. (2019) Advanced glycation end products are elevated in estrogen receptor-positive breast cancer patients, alter response to therapy, and can be targeted by lifestyle intervention. Breast Cancer Res Treat 173:559–571

    Article  CAS  Google Scholar 

  29. Mijwel S, Jervaeus A, Bolam KA et al. (2019) High-intensity exercise during chemotherapy induces beneficial effects 12 months into breast cancer survivorship. J Cancer Surviv 13:244–256

    Article  Google Scholar 

  30. Dimauro I, Grazioli E, Antinozzi C et al. (2021) Estrogen-receptor-positive breast cancer in postmenopausal women: the role of body composition and physical exercise. Int J Environ Res Public Health 18(18):9834

    Article  CAS  Google Scholar 

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Correspondence to Cristina Antinozzi.

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Gli autori Cristina Antinozzi, Ivan Dimauro, Marco Lista, Elisa Grazioli, Attilio Parisi e Paolo Sgrò dichiarano di non avere conflitti di interesse.

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Proposto da Emanuela Greco.

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Antinozzi, C., Dimauro, I., Lista, M. et al. Ruolo dell’esercizio fisico nel trattamento del carcinoma della mammella positivo al recettore degli estrogeni. L'Endocrinologo 23, 238–246 (2022). https://doi.org/10.1007/s40619-022-01063-y

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