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Terapia sostitutiva tiroidea e risposta tissutale: quando il TSH non basta

Sommario

Il trattamento dell’ipotiroidismo si basa sulla somministrazione orale di levotiroxina. Recenti evidenze hanno documentato l’incapacità di garantire normali livelli tissutali di ormoni tiroidei. Inoltre, è emersa la parziale inadeguatezza del TSH come marcatore universale del compenso. Alcuni studi sono stati condotti con l’obiettivo di individuare marcatori tissutali più informativi sul compenso periferico. Ad oggi, tuttavia, non sono stati identificati marcatori utili nella pratica clinica.

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Correspondence to Giulia Brigante.

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Le autrici Maria Laura Monzani, Francesca Piccinini, Manuela Simoni, Giulia Brigante dichiarano di non avere conflitti di interesse.

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Proposto da Manuela Simoni.

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Monzani, M.L., Piccinini, F., Simoni, M. et al. Terapia sostitutiva tiroidea e risposta tissutale: quando il TSH non basta. L'Endocrinologo 21, 319–324 (2020). https://doi.org/10.1007/s40619-020-00775-3

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  • DOI: https://doi.org/10.1007/s40619-020-00775-3

Parole chiave

  • Ormoni tiroidei
  • TSH
  • Levotiroxina
  • Conversione periferica T4-T3
  • Risposta tissutale
  • Ipotiroidismo