Skip to main content
SpringerLink
Log in

Riscontro incidentale di ipercaptazione surrenalica alla PET/TC: significato e algoritmo diagnostico

  • RASSEGNA
  • Published:
L'Endocrinologo Aims and scope

Sommario

Nella maggior parte dei casi l’incidentaloma surrenalico è un adenoma corticale non secernente, ma talvolta può rappresentare un tumore maligno primitivo o metastatico. Quando il riscontro di incidentaloma avviene durante un’indagine PET/CT con 18F-FDG, la caratterizzazione metabolica della massa surrenalica permette, con elevata sensibilità e specificità, di distinguere le lesioni benigne da quelle maligne. In altri casi, l’integrazione con altre metodiche di imaging TC e/o RMN si rende necessaria. La valutazione iniziale dovrebbe comunque includere indagini ormonali per l’identificazione di lesioni iperfunzionanti.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Bibliografia

  1. Barzon L, Boscaro M (2000) Diagnosis and management of adrenal incidentalomas. J Urol 163:398

    Article  CAS  PubMed  Google Scholar 

  2. Boland GW, Dwamena BA, Jagtiani Sangwaiya M et al. (2011) Characterization of adrenal masses by using FDG PET: a systematic review and meta-analysis of diagnostic test performance. Radiology 259(1):117–126

    Article  PubMed  Google Scholar 

  3. Kandathil A, Wong KK, Wale DJ et al. (2015) Metabolic and anatomic characteristics of benign and malignant adrenal masses on positron emission tomography/computed tomography: a review of literature. Endocrine 49(1):6–26

    Article  CAS  PubMed  Google Scholar 

  4. Kim SJ, Lee SW, Pak K et al. (2018) Diagnostic accuracy of 18F-FDG PET or PET/CT for the characterization of adrenal masses: a systematic review and meta-analysis. Br J Radiol 91(1086):20170520

    Article  PubMed  PubMed Central  Google Scholar 

  5. Boland GW, Lee MJ, Gazelle GS et al. (1998) Characterization of adrenal masses using unenhanced CT: an analysis of the CT literature. Am J Roentgenol 171:201–204

    Article  CAS  Google Scholar 

  6. Metser U, Miller E, Lerman H et al. (2006) 18F-FDG PET/CT in the evaluation of adrenal masses. J Nucl Med 47:32–37

    PubMed  Google Scholar 

  7. Perri M, Erba P, Volterrani D et al. (2011) Adrenal masses in patients with cancer: PET/CT characterization with combined CT histogram and standardized uptake value PET analysis. Am J Roentgenol 197:209–216

    Article  Google Scholar 

  8. Blake MA, Slattery JM, Kalra MK et al. (2006) Adrenal lesions: characterization with fused PET/CT image in patients with proved or suspected malignancy—initial experience. Radiology 238:970–977

    Article  PubMed  Google Scholar 

  9. Yun M, Kim W, Alnafisi N et al. (2001) 18F-FDG PET in characterizing adrenal lesions detected on CT or MRI. J Nucl Med 42:1795–1799

    CAS  PubMed  Google Scholar 

  10. Kumar R, Xiu Y, Yu JQ et al. (2004) 18F-FDG PET in evaluation of adrenal lesions in patients with lung cancer. J Nucl Med 45:2058–2062

    PubMed  Google Scholar 

  11. Timmers HJ, Kozupa A, Chen CC et al. (2007) Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma. J Clin Oncol 25:2262–2269

    Article  PubMed  Google Scholar 

  12. Leboulleux S, Dromain C, Bonniaud G et al. (2006) Diagnostic and prognostic value of 18-fluorodeoxyglucose positron emission tomography in adrenocortical carcinoma: a prospective comparison with computed tomography. J Clin Endocrinol Metab 91:920–925

    Article  CAS  PubMed  Google Scholar 

  13. Basu S, Nair N (2005) 18F-FDG uptake in bilateral adrenal hyperplasia causing Cushing’s syndrome. Eur J Nucl Med Mol Imaging 32:384

    Article  PubMed  Google Scholar 

  14. Alencar GA, Fragoso MC, Yamaga LY et al. (2011) 18F-FDG-PET/CT imaging of ACTH-independent macronodular adrenocortical hyperplasia (AIMAH) demonstrating increased 18F-FDG uptake. J Clin Endocrinol Metab 96:3300–3301

    Article  CAS  PubMed  Google Scholar 

  15. Berland LL, Silverman SG, Gore RM et al. (2010) Managing incidental findings on abdominal CT: white paper of the ACR incidental findings committee. J Am Coll Radiol 7(10):754–773

    Article  PubMed  Google Scholar 

  16. Outwater EK, Siegelman ES, Radecki PD et al. (1995) Distinction between benign and malignant adrenal masses: value of T1-weighted chemical-shift MR imaging. Am J Roentgenol 165(3):579–583

    Article  CAS  Google Scholar 

  17. Rha SE, Byun JY, Jung SE et al. (2003) Neurogenic tumors in the abdomen: tumor types and imaging characteristics. Radiographics 23:29–43

    Article  PubMed  Google Scholar 

  18. Terzolo M, Stigliano A, Chiodini I et al. (2011) Italian Association of Clinical Endocrinologists. AME position statement on adrenal incidentaloma. Eur J Endocrinol 164(6):851–870

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Struttura Complessa di Medicina Nucleare, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italia

    Alice Lorenzoni & Ettore Seregni

Authors
  1. Alice Lorenzoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ettore Seregni
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ettore Seregni.

Ethics declarations

Conflitto di interesse

Gli autori Alice Lorenzoni e Ettore Seregni dichiarano di non avere conflitti di interesse.

Consenso informato

Lo studio presentato in questo articolo non ha richiesto sperimentazione umana.

Studi sugli animali

Gli autori di questo articolo non hanno eseguito studi sugli animali.

Additional information

Proposto da Alfredo Campennì.

Materiale elettronico supplementare

I link al materiale elettronico supplementare sono elencati qui sotto.

(DOC 26 kB)

(DOC 24 kB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lorenzoni, A., Seregni, E. Riscontro incidentale di ipercaptazione surrenalica alla PET/TC: significato e algoritmo diagnostico. L'Endocrinologo 20, 286–291 (2019). https://doi.org/10.1007/s40619-019-00620-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40619-019-00620-2

Parole chiave

Search

Navigation