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Sindromi cliniche surrenaliche riferibili a recettori illeciti

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L'Endocrinologo Aims and scope

Sommario

La regolazione della produzione di cortisolo o di aldosterone quando l’ACTH o il sistema renina angiotensina sono soppressi, è stato motivo di numerosi studi negli ultimi anni. Questo ha permesso d’identificare la presenza di recettori accoppiati alla proteina G (GPCRs) che, espressi in modo aberrante o illecito sul tessuto tumorale, mimano gli eventi cellulari che sono normalmente innescati dagli stimoli fisiologici. Inoltre, è stata un’opportunità d’identificare nuove opzioni terapeutiche mediante l’utilizzo di antagonisti dei recettori o l’inibizione del peptide coinvolto.

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Authors and Affiliations

  1. Endocrinologia, Dipartimento di Medicina, Azienda Ospedaliera/Università di Padova, Padova, Italia

    Nora M. Albiger, Carla Scaroni & Franco Mantero

Authors
  1. Nora M. Albiger
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  2. Carla Scaroni
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  3. Franco Mantero
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Corresponding author

Correspondence to Nora M. Albiger.

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Conflitto di interesse

Gli autori Nora M. Albiger, Carla Scaroni e Franco Mantero dichiarano di non avere conflitti di interesse.

Consenso informato

Lo studio presentato in questo articolo non ha richiesto sperimentazione umana.

Studi sugli animali

Gli autori di questo articolo non hanno eseguito studi su animali.

Additional information

Proposto da Francesco Trimarchi.

Materiale elettronico supplementare

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Albiger, N.M., Scaroni, C. & Mantero, F. Sindromi cliniche surrenaliche riferibili a recettori illeciti. L'Endocrinologo 19, 231–236 (2018). https://doi.org/10.1007/s40619-018-00480-2

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  • DOI: https://doi.org/10.1007/s40619-018-00480-2

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