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L’iperaldosteronismo primitivo: dalla genetica alla terapia

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L’iperaldosteronismo primitivo (PA) è la forma più frequente di ipertensione secondaria e i pazienti affetti presentano aumentato rischio di eventi cardio e cerebrovascolari rispetto agli ipertesi essenziali. I due sottotipi più comuni di PA sono l’adenoma producente aldosterone e l’iperplasia bilaterale, mentre più rare sono le forme familiari (FH-I, II, III). La causa molecolare dell’FH-I è rappresentata dal gene chimerico \(\mathit{CYP11}B\mathit{1} /B\mathit{2}\), mentre mutazioni germinali di KCNJ5 sono alla base dell’FH-III.

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Authors and Affiliations

  1. Divisione di Medicina Interna 4–Centro Ipertensione Arteriosa, Dipartimento di Scienze Mediche, Università di Torino, Via Genova 3, 10126, Torino, Italia

    Silvia Monticone, Martina Tetti, Franco Veglio & Paolo Mulatero

Authors
  1. Silvia Monticone
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  2. Martina Tetti
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  3. Franco Veglio
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  4. Paolo Mulatero
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Corresponding author

Correspondence to Paolo Mulatero.

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Conflitto di interesse

Gli autori Silvia Monticone, Martina Tetti, Franco Veglio e Paolo Mulatero dichiarano di non avere conflitti di interesse.

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Lo studio presentato in questo articolo non ha richiesto sperimentazione umana.

Studi sugli animali

Gli autori di questo articolo non hanno eseguito studi sugli animali.

Additional information

Proposto da Emanuela Arvat.

Materiale elettronico supplementare

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Monticone, S., Tetti, M., Veglio, F. et al. L’iperaldosteronismo primitivo: dalla genetica alla terapia. L'Endocrinologo 17, 90–96 (2016). https://doi.org/10.1007/s40619-016-0194-x

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  • DOI: https://doi.org/10.1007/s40619-016-0194-x

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