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La leptina nella fisiologia e patologia della funzione riproduttiva femminile

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L'Endocrinologo Aims and scope

Sommario

La leptina ha un ruolo fondamentale nell’integrazione tra le riserve energetiche (il tessuto adiposo) e la funzione riproduttiva. I circuiti neuroendocrini ipotalamici sono la struttura deputata a tale integrazione. La leptina ha anche un ruolo fondamentale nell’innesco dello sviluppo puberale. Alterazioni in eccesso e in difetto del bilancio energetico alterano le concentrazioni ematiche di leptina. In alcune patologie, la somministrazione di leptina ha risultati terapeutici molto interessanti. Nella sindrome dell’ovaio policistico, esistono ancora aspetti oscuri sul possibile ruolo di leptina in relazione alla frequente presenza di obesità, soprattutto addomino-viscerale, e i disordini metabolici associati alla sindrome stessa.

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Authors and Affiliations

  1. U.O. di Endocrinologia, Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Policlinico S. Orsola-Malpighi, Università Alma Mater Studiorum, Bologna, Italia

    Andrea Repaci & Renato Pasquali

Authors
  1. Andrea Repaci
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  2. Renato Pasquali
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Corresponding author

Correspondence to Renato Pasquali.

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Conflitto di interesse

Gli autori Andrea Repaci e Renato Pasquali dichiarano di non avere conflitti di interesse.

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Lo studio presentato in questo articolo non ha richiesto sperimentazione umana.

Studi sugli animali

Gli autori di questo articolo non hanno eseguito studi sugli animali.

Additional information

Proposto da Paolo Moghetti.

Materiale elettronico supplementare

I link al materiale elettronico supplementare sono elencati qui sotto.

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Repaci, A., Pasquali, R. La leptina nella fisiologia e patologia della funzione riproduttiva femminile. L'Endocrinologo 17, 28–36 (2016). https://doi.org/10.1007/s40619-016-0177-y

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  • DOI: https://doi.org/10.1007/s40619-016-0177-y

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