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Cross-talk testicolo e osso

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Sommario

Negli ultimi anni il “dialogo” endocrino tra testicolo e osso si è intrecciato di nuovi attori a formare un cross-talk particolarmente interessante, anche per le possibili applicazioni diagnostiche e di management clinico dei pazienti con ipogonadismo e/o osteoporosi. La cellula di Leydig partecipa al metabolismo osseo attraverso la produzione di testosterone e INSL3 e la 25-idrossilazione della vitamina D. L’osteocalcina prodotta dagli osteoblasti stimola la produzione del testosterone e partecipa alla regolazione del metabolismo aumentando la produzione e la sensibilità insulinica.

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Bibliografia

  1. Callewaert F, Boonen S, Vanderschueren D (2010) Sex steroids and the male skeleton: a tale of two hormones. Trends Endocrinol Metab 21:89–99

    Article  CAS  PubMed  Google Scholar 

  2. Bhasin S, Cunningham GR, Hayes FJ et al. (2010) Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 95:2536–2559

    Article  CAS  PubMed  Google Scholar 

  3. Ferlin A, Selice R, Carraro U, Foresta C (2013) Testicular function and bone metabolism—beyond testosterone. Nat Rev Endocrinol 9:548–554

    Article  CAS  PubMed  Google Scholar 

  4. Karsenty G, Oury F (2012) Biology without walls: the novel endocrinology of bone. Annu Rev Physiol 74:87–105

    Article  CAS  PubMed  Google Scholar 

  5. Karsenty G (2012) The mutual dependence between bone and gonads. J Endocrinol 213:107–114

    Article  CAS  PubMed  Google Scholar 

  6. Oury F, Sumara G, Sumara O et al. (2011) Endocrine regulation of male fertility by the skeleton. Cell 144:796–809

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Ivell R, Anand-Ivell R (2011) Biological role and clinical significance of insulin-like peptide 3. Curr Opin Endocrinol Diabetes Obes 18:210–216

    Article  CAS  PubMed  Google Scholar 

  8. Cheng JB, Levine MA, Bell NH et al. (2001) Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Proc Natl Acad Sci USA 101:7711–7715

    Article  Google Scholar 

  9. Lee DM, Tajar A, Pye SR et al. (2012) Association of hypogonadism with vitamin D status: the European Male Ageing Study. Eur J Endocrinol 66:77–85

    Article  Google Scholar 

  10. Foresta C, Strapazzon G, De Toni L et al. (2011) Bone mineral density and testicular failure: evidence for a role of vitamin D25 hydroxylase in human testis. J Clin Endocrinol Metab 96:E646–652

    Article  CAS  PubMed  Google Scholar 

  11. Giannetta E, Gianfrilli D, Barbagallo F et al. (2012) Subclinical male hypogonadism. Best Pract Res Clin Endocrinol Metab 26:539–550

    Article  CAS  PubMed  Google Scholar 

  12. Hannemann A, Breer S, Wallaschofski H et al. (2013) Osteocalcin is associated with testosterone in the general population and selected patients with bone disorders. Andrology 1:469–474

    Article  CAS  PubMed  Google Scholar 

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Conflitto di interesse

Gli autori Alberto Ferlin e Carlo Foresta dichiarano di non avere conflitti di interessi.

Consenso informato

Lo studio presentato in questo articolo non ha richiesto sperimentazione umana.

Studi sugli animali

Gli autori di questo articolo non hanno eseguito studi sugli animali.

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Authors and Affiliations

  1. Dipartimento di Medicina e Servizio per la Patologia della Riproduzione Umana, Università degli Studi di Padova, Via Giustiniani, 2, 35100, Padova, Italia

    Alberto Ferlin & Carlo Foresta

Authors
  1. Alberto Ferlin
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  2. Carlo Foresta
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Corresponding author

Correspondence to Carlo Foresta.

Additional information

Proposta da Marco Federghini.

Materiale elettronico supplementare

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Ferlin, A., Foresta, C. Cross-talk testicolo e osso. L'Endocrinologo 15, 158–164 (2014). https://doi.org/10.1007/s40619-014-0048-3

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  • DOI: https://doi.org/10.1007/s40619-014-0048-3

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