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Epicardial and pericoronary adipose tissue and coronary plaque burden in patients with Cushing’s syndrome: a propensity score-matched study

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Abstract

Purpose

To assess coronary inflammation by measuring the volume and density of the epicardial adipose tissue (EAT), perivascular fat attenuation index (FAI) and coronary plaque burden in patients with Cushing’s syndrome (CS) based on coronary computed tomography angiography (CCTA).

Methods

This study included 29 patients with CS and 58 matched patients without CS who underwent CCTA. The EAT volume, EAT density, FAI and coronary plaque burden were measured. The high-risk plaque (HRP) was also evaluated. CS duration from diagnosis, 24-h urinary free cortisol (UFC), and abdominal visceral adipose tissue volume (VAT) of CS patients were recorded.

Results

The CS group had higher EAT volume (146.9 [115.4, 184.2] vs. 119.6 [69.0, 147.1] mL, P = 0.006), lower EAT density (− 78.79 ± 5.89 vs. − 75.98 ± 6.03 HU, P = 0.042), lower FAI (− 84.0 ± 8.92 vs. − 79.40 ± 10.04 HU, P = 0.038), higher total plaque volume (88.81 [36.26, 522.5] vs. 44.45 [0, 198.16] mL, P = 0.010) and more HRP plaques (7.3% vs. 1.8%, P = 0.026) than the controls. The multivariate analysis suggested that CS itself (β [95% CI], 29.233 [10.436, 48.03], P = 0.014), CS duration (β [95% CI], 0.176 [0.185, 4.242], P = 0.033), and UFC (β [95% CI], 0.197 [1.803, 19.719], P = 0.019) were strongly associated with EAT volume but not EAT density, and EAT volume (β [95% CI] − 0.037[− 0.058, − 0.016], P = 0.001) not CS was strongly associated with EAT density. EAT volume, FAI and plaque burden increased (all P < 0.05) in 6 CS patients with follow-up CCTA. The EAT volume had a moderate correlation with abdominal VAT volume (r = 0.526, P = 0.008) in CS patients.

Conclusions

Patients with CS have higher EAT volume and coronary plaque burden but less inflammation as detected by EAT density and FAI. The EAT density is associated with EAT volume but not CS itself.

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Funding

This study was supported by the following fundings: Natural Science Foundation of China under Grant: 8217070113. Natural Science Foundation of China under Grant: 82101988. Innovative research team of high-level local universities in Shanghai: SHSMU-ZDCX20210702. Shanghai Sailing Program: 21YF1426200.

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Author notes

  1. M. Wang and L. Qin contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No.197 Ruijin Er Road, Shanghai, 200025, China

    M. Wang, L. Qin, W. Bao, L. Han, F. Yan & W. Yang

  2. Siemens Healthineers CT Collaboration, Shanghai, China

    Z. Xu

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Correspondence to W. Yang.

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Zhihan Xu is an employee of Siemens Healthineers. The remaining authors declare that they have no conflict of interest with each other.

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This article does not contain any studies directly involving human participants, as it is a review of data already collected in a Cushing’s Syndrome database.

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Our hospital ethic committee approved this retrospective study, and the informed consent forms were waived.

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Wang, M., Qin, L., Bao, W. et al. Epicardial and pericoronary adipose tissue and coronary plaque burden in patients with Cushing’s syndrome: a propensity score-matched study. J Endocrinol Invest (2024). https://doi.org/10.1007/s40618-023-02295-x

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